Results 11 to 20 of about 955,627 (248)

Characterizing RecA-Independent Induction of Shiga toxin2-encoding Phages by EDTA Treatment [PDF]

, 2012
The bacteriophage life cycle has an important role in Shiga toxin (Stx) expression. The induction of Shiga toxin-encoding phages (Stx phages) increases toxin production as a result of replication of the phage genome, and phage lysis of the host cell also
Muniesa Maite, Lejla Imamovic (180270), Lejla Imamovic, Maite Muniesa (66350), Maite Muniesa, Imamovic Lejla, Muniesa Pérez, Ma. Teresa, Muniesa Pérez, Ma Teresa, Imamovic, Lejla   +8 more
core   +3 more sources

The coevolution of toxin and antitoxin genes drives the dynamics of bacterial addiction complexes and intragenomic conflict [PDF]

, 2012
Bacterial genomes commonly contain 'addiction' gene complexes that code for both a toxin and a corresponding antitoxin. As long as both genes are expressed, cells carrying the complex can remain healthy.
Rankin, Daniel J., Leighton A. Turner, Daniel J. Rankin, Heinemann, Jack A., Brown, Sam P., Sam P. Brown, Turner, Leighton A., Jack A. Heinemann   +7 more
core   +1 more source

Membrane-Pore Forming Characteristics of the Bordetella pertussis CyaA-Hemolysin Domain

Toxins, 2015
Previously, the 126-kDa Bordetella pertussis CyaA pore-forming/hemolysin (CyaA-Hly) domain was shown to retain its hemolytic activity causing lysis of susceptible erythrocytes. Here, we have succeeded in producing, at large quantity and high purity, the
Chattip Kurehong, Chalermpol Kanchanawarin, Busaba Powthongchin, Gerd Katzenmeier, Chanan Angsuthanasombat   +4 more
doaj   +1 more source

Structural and functional insights into the delivery of a bacterial Rhs pore-forming toxin to the membrane

Nature Communications, 2023
Bacterial competition is a significant driver of toxin polymorphism, which allows continual compensatory evolution between toxins and the resistance developed to overcome their activity.
Amaia González-Magaña, Igor Tascón, Jon Altuna-Alvarez, María Queralt-Martín, Jake Colautti, Carmen Velázquez, Maialen Zabala, Jessica Rojas-Palomino, Marité Cárdenas, Antonio Alcaraz, John C. Whitney, Iban Ubarretxena-Belandia, David Albesa-Jové   +12 more
doaj   +1 more source

Enhancement of insect susceptibility and larvicidal efficacy of Cry4Ba toxin by calcofluor

Parasites & Vectors, 2018
Background Mosquitoes transmit many vector-borne infectious diseases including malaria, dengue, chikungunya, yellow fever, filariasis, and Japanese encephalitis. The insecticidal δ-endotoxins Cry4, Cry11, and Cyt produced from Bacillus thuringiensis have
Somphob Leetachewa, Narumol Khomkhum, Somsri Sakdee, Ping Wang, Saengduen Moonsom   +4 more
doaj   +1 more source

The role of TcdB and TccC subunits in secretion of the photorhabdus Tcd toxin complex [PDF]

, 2013
The Toxin Complex (TC) is a large multi-subunit toxin encoded by a range of bacterial pathogens. The best-characterized examples are from the insect pathogens Photorhabdus, Xenorhabdus and Yersinia.
Guowei Yang, Yang Guowei, Yang, Guowei, Guowei Yang (163967), Waterfield, Nicholas R., Nicholas R. Waterfield (163985), Nicholas R Waterfield, Waterfield Nicholas R.   +7 more
core   +1 more source

Functional Contributions of Positive Charges in the Pore-Lining Helix 3 of the Bordetella pertussis CyaA-Hemolysin to Hemolytic Activity and Ion-Channel Opening

Toxins, 2017
The Bordetella pertussis CyaA-hemolysin (CyaA-Hly) domain was previously demonstrated to be an important determinant for hemolysis against target erythrocytes and ion-channel formation in planar lipid bilayers (PLBs).
Chattip Kurehong, Chalermpol Kanchanawarin, Busaba Powthongchin, Panchika Prangkio, Gerd Katzenmeier, Chanan Angsuthanasombat   +5 more
doaj   +1 more source

Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology [PDF]

, 2015
Toxin-antitoxin (TA) modules are ubiquitous molecular switches controlling bacterial growth via the release of toxins that inhibit cell proliferation.
Gerdes, K., Glatter, Timo, Dehio, Christoph, Alexander Harms, Goepfert, A., Scheu, P., Kenn Gerdes, Glatter, T. ; https://orcid.org/, Schirmer, T., Harms, Alexander, Christoph Dehio, Harms, A., Timo Glatter, Stanger, Frédéric Valentin, Gerdes, Kenn, Dehio, C., Schirmer, Tilman, Harms, Alexander; id_orcid, de Jong, I., de Jong, Imke Greet, Stanger, F., Tilman Schirmer, Patrick Daniel Scheu, Arnaud Goepfert, Scheu, Patrick Daniel, Frédéric Valentin Stanger, Imke Greet de Jong, Goepfert, Arnaud   +27 more
core   +1 more source

Paeoniflorin Derivative in Paeoniae Radix Aqueous Extract Suppresses Alpha-Toxin of Staphylococcus aureus

Frontiers in Microbiology, 2021
The emergence and dissemination of bacterial infections is paralyzing our public health systems worldwide. Worse still, there are no effective antibiotics against bacterial toxins, which facilitate the infection.
Xiaoye Liu, Xiaoye Liu, Xiaoye Liu, Yafei Zhang, Zengshun Li, Pengpeng Zhang, Ying-Jian Sun, Yi-Jun Wu   +7 more
doaj   +1 more source

Comparative genomics of Shiga toxin encoding bacteriophages [PDF]

, 2012
Background Stx bacteriophages are responsible for driving the dissemination of Stx toxin genes (stx) across their bacterial host range. Lysogens carrying Stx phages can cause severe, lifethreatening disease and Stx toxin is an integral virulence factor.
Alan J McCarthy, Darby Alistair C, Alistair C Darby, Allison Heather E, Rooks David J, Rooks, David, Smith, Darren, Paul CM Fogg, Thomson, Nicholas, David J Rooks, Smith Darren L, McCarthy Alan J, McCarthy, Alan, Heather E Allison, Darren L Smith, Allison, Heather, Fogg Paul CM, Nick R Thomson, Fogg, Paul, Darby, Alistair, Thomson Nick R   +20 more
core   +1 more source