Bacterial viruses as human vaccines?
Expert Review of Vaccines, 2004 Bacteriophages (or phages) are viruses of bacteria, consisting of nucleic acid packaged within a protein coat. In eukaryotic hosts, phages are unable to replicate and in the absence of a suitable prokaryotic host, behave as inert particulate antigens. In recent years, work has shown that whole phage particles can be used to deliver vaccines in the form
John B. March, Jason R. Clark
openaire +3 more sources
AN ADAPTATION OF QUALITY CONTROL CHART METHODS TO BACTERIAL VACCINE POTENCY TESTING [PDF]
, 1951 H. C. Batson +2 more
openalex +1 more source
Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance
Advanced Science, EarlyView.Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai +5 more
wiley +1 more source
NTHi killing activity is reduced in COPD patients and is associated with a differential microbiome
Respiratory ResearchChronic obstructive pulmonary disease (COPD) is a chronic lung disease characterized by airway obstruction and inflammation. Non-typeable Haemophilus influenzae (NTHi) lung infections are common in COPD, promoting frequent exacerbations and accelerated ...
Vancheswaran Gopalakrishnan +28 more
doaj +1 more source
Vaccipharma 2020. V International Congress on Pharmacology of Vaccines
VacciMonitor, 2020 The Organizing Committee of the “V International Congress on Pharmacology of Vaccines” (Vaccipharma 2020) organized by the Cuban Society of Pharmacology, BioCubaFarma and the International Union of Basic and Clinical Pharmacology (IUPHAR) would like to ...
Mario Landys Chovel Cuervo +1 more
doaj
A METHOD OF ESTIMATING THE STRENGTH OF A VACCINE BY A STANDARD BACTERIAL EMULSION [PDF]
, 1912 John Hicks
openalex +1 more source
Peptide‐Based Biomaterials as a Promising Tool for Cancer Radiotherapy
Advanced Science, EarlyView.This review provides a systematic overview of peptide‐based biomaterials in tumor radiotherapy, covering their roles as both radiosensitizers and radiopharmaceuticals. Peptide‐based radiosensitizers are generally divided into three categories: peptides as direct radiosensitizers, peptides as carriers of radiosensitizers, and targeted‐peptide‐modified ...
Qian Wang, Xinhui Chu, Jianfeng Liu
wiley +1 more source
Analytical Insights into Protein–Alum Interactions and Their Impact on Conformational Epitope
PharmaceuticsSeveral alum-adjuvanted vaccines have been licensed in the past 40 years. Despite its extensive and continuous use, the immune mechanism of action of alum adjuvants is not yet completely understood. Many different variables during the formulation process
Alessio Corrado +7 more
doaj +1 more source
ULCERATION OF THE FACE AND FAUCES TREATED BY BACTERIAL VACCINES [PDF]
, 1910 J. C. MacWatters
openalex +1 more source
PFKFB2‐Driven Glycolysis Promotes Dendritic Cell Maturation and Exacerbates Acute Lung Injury
Advanced Science, EarlyView.Paraquat (PQ) or lipopolysaccharide (LPS) exposure activates the HIF‐1α–PFKFB2 pathway, driving glycolysis in dendritic cells (DCs). This metabolic shift enhances DC maturation and immune activation, exacerbating acute lung injury (ALI). This study demonstrates that PFKFB2‐driven glycolytic reprogramming in DCs plays a critical role in the pathogenesis
Ding Yuan +17 more
wiley +1 more source