Results 101 to 110 of about 129,578 (294)

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Stability Study of Iriba Brucellosis Full-dose and Reduced-dose Vaccine Produced by Razi Institute in Iran

Archives of Razi Institute, 2015
Stability study of biological products plays an important role for determination of product changes in maintenance period and ensuring of safety and efficacy of vaccines.
Hasannia, E., Soleimani, S., Alamian, S., Behrozikhah, A., Emadi, A., Dostdari, S.   +5 more
doaj  

A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates

Advanced Science, EarlyView.
Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao, Yan Deng, Jianjian Han, Yong Xie, Kai Bao, Lixin Ma, Lilong Liu, Wuxiang Mao   +7 more
wiley   +1 more source

ENGINEERING BACTERIAL GLYCOBIOLOGY FOR THE CREATION OF GLYCOCONJUGATE VACCINES [PDF]

, 2017
The use of vaccines has led to the effective eradication of several human diseases which were once epidemic such as smallpox and polio. Vaccines have also dramatically decreased the incidence of other diseases including rabies, mumps, and measles.
Stevenson, Taylor Currie
core   +1 more source

Discriminator‐Guided Inverse Folding for Multi‐Property Protein Design

Advanced Science, EarlyView.
Discriminator‐Guided Inverse Folding (DGIF) integrates multiple property predictors trained from single‐property datasets to guide protein sequence generation from a backbone structure. DGIF enables simultaneous improvement of thermostability and solubility without requiring multi‐property annotated datasets and generates designs that move toward the ...
Yuchuan Zheng, Chuyi Liu, Zhaoming Liu, Mao Su, Chenyu Tang, Xiang Zheng, Hao Zhang, Jingyuan Li   +7 more
wiley   +1 more source

Putative correlates of protection against shigellosis assessing immunomarkers across responses to S. sonnei investigational vaccine

npj Vaccines
Shigella spp. are a leading bacterial cause of diarrhea. No widely licensed vaccines are available and there is no generally accepted correlate of protection. We tested a S.
Valentino Conti, Omar Rossi, Kristen A. Clarkson, Francesca Mancini, Usman N. Nakakana, Eleanna Sarakinou, Andrea Callegaro, Pietro Ferruzzi, Alessandra Acquaviva, Ashwani Kumar Arora, Elisa Marchetti, Francesca Necchi, Robert W. Frenck, Laura B. Martin, Robert W. Kaminski, Audino Podda, Francesca Micoli   +16 more
doaj   +1 more source

Bacterial genomics and vaccine design

Expert Review of Vaccines, 2003
Complete genome sequences are available for an increasing number of pathogenic bacteria. These new data are beginning to make an impact on the understanding of bacterial evolution and virulence. Thus far, however, vaccine development has had little benefit from genomics.
Samantha L, Sampson, Jyothi, Rengarajan, Eric J, Rubin   +2 more
openaire   +2 more sources

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Phage-specific immunity impairs efficacy of bacteriophage targeting Vancomycin Resistant Enterococcus in a murine model

Nature Communications
Bacteriophage therapy is a promising approach to address antimicrobial infections though questions remain regarding the impact of the immune response on clinical effectiveness.
Julia D. Berkson, Claire E. Wate, Garrison B. Allen, Alyxandria M. Schubert, Kristin E. Dunbar, Michael P. Coryell, Rosa L. Sava, Yamei Gao, Jessica L. Hastie, Emily M. Smith, Charlotte R. Kenneally, Sally K. Zimmermann, Paul E. Carlson   +12 more
doaj   +1 more source

Bacterial surface proteins and vaccines [PDF]

F1000 Biology Reports, 2010
Surface-associated proteins play a key role in bacterial physiology and pathogenesis and are the major targets for vaccine development. Recent advances in defining the proteins associated with, and protruding out of, bacterial cells to a high level of accuracy are substantially contributing to accelerating the process of vaccine target identification ...
openaire   +2 more sources