Results 101 to 110 of about 129,985 (296)

Bacterial genomics and vaccine design

Expert Review of Vaccines, 2003
Complete genome sequences are available for an increasing number of pathogenic bacteria. These new data are beginning to make an impact on the understanding of bacterial evolution and virulence. Thus far, however, vaccine development has had little benefit from genomics.
Samantha L, Sampson, Jyothi, Rengarajan, Eric J, Rubin   +2 more
openaire   +2 more sources

A Glucose Metabolism‐Modulatory Nanobiohybrid Vaccine Platform Promotes Anti‐Tumor Immunity by Orchestrating Autophagy‐Dependent Cross‐Presentation and H2S‐Enhanced NLRP3 Inflammasome Signaling

Advanced Science, EarlyView.
A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang, Yimin Gong, Jianing Li, Tianze Wu, Mingli Deng, Yannan Yang   +5 more
wiley   +1 more source

Phage-specific immunity impairs efficacy of bacteriophage targeting Vancomycin Resistant Enterococcus in a murine model

Nature Communications
Bacteriophage therapy is a promising approach to address antimicrobial infections though questions remain regarding the impact of the immune response on clinical effectiveness.
Julia D. Berkson, Claire E. Wate, Garrison B. Allen, Alyxandria M. Schubert, Kristin E. Dunbar, Michael P. Coryell, Rosa L. Sava, Yamei Gao, Jessica L. Hastie, Emily M. Smith, Charlotte R. Kenneally, Sally K. Zimmermann, Paul E. Carlson   +12 more
doaj   +1 more source

Bacterial surface proteins and vaccines [PDF]

F1000 Biology Reports, 2010
Surface-associated proteins play a key role in bacterial physiology and pathogenesis and are the major targets for vaccine development. Recent advances in defining the proteins associated with, and protruding out of, bacterial cells to a high level of accuracy are substantially contributing to accelerating the process of vaccine target identification ...
openaire   +2 more sources

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Progress and Challenges in Antimicrobial Resistance and Bacterial Vaccines [PDF]

, 2023
In recent decades, pathogens have continued to strike humans in the form of newly emerging or re-emerging infectious diseases, opportunistic infectious diseases, and infections caused by drug-resistant microbes.
Deepak Chandran (229041), Abbas Al Mutair (11419154), Ahmad Mu’arif (20268534), Kuldeep Dhama (3156801), Nurfadhilah Asfa (20268531), Andri Frediansyah (20256198), Andi Maghfirah Nurul Fitri (20268528), Talha Bin Emran (11725562), Nana Juniarti Natsir Djide (20268525), Saad Alhumaid (11419160), Ali A Rabaan (11796447), Nur Rahma Rumata (20268522), Firzan Nainu (8627838)   +12 more
core  

Chemoenzymatic Synthesis of Well‐Defined α(2,8)‐ and α(2,9)‐Linked Oligosialosides

Angewandte Chemie, EarlyView.
Well‐defined α(2,8)‐ and α(2,9)‐linked oligosialic acids of different lengths can be prepared by employing recombinant bacterial polysialyltransferases in combination with chemically modified CMP‐Neu5Ac derivatives. After transfer, a sialoside is formed bearing an artificial entity, which blocks further glycosylation.
Jelle A. Fok, Keshav Kishor, Mehman I. Bunyatov, Gerlof P. Bosman, Geert‐Jan Boons   +4 more
wiley   +2 more sources

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

The effect of HIV-exposure on immune responses to expanded programme on immunization vaccines and antigens [PDF]

, 2013
Includes abstract.Includes bibliographical references.Immunization against vaccine-preventable infections is essential to reducing childhood morbidity and mortality.
Kidzeru, Elvis Banboye
core  

Metabiotic Medicine of Symbiotic Corynebacteria: Prevention, Treatment and Immunological Safety

Эпидемиология и вакцинопрофилактика, 2019
Relevance. Acute respiratory diseases (ARD) occupy a leading position in infectious pathology. Patients who often suffer from the acute respiratory diseases, in most cases have an ENT pathology against the background of immunodeficiency state.
E. A. Shmeleva, A. E. Vershinin, S. S. Andina   +2 more
doaj   +1 more source