Results 81 to 90 of about 129,985 (296)

Live bacterial vaccines – a review and identification of potential hazards [PDF]

, 2006
The use of live bacteria to induce an immune response to itself or to a carried vaccine component is an attractive vaccine strategy. Advantages of live bacterial vaccines include their mimicry of a natural infection, intrinsic adjuvant properties and ...
Ann Detmer, Jacob Glenting, Glenting Jacob, Detmer Ann   +3 more
core   +1 more source

A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates

Advanced Science, EarlyView.
Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao, Yan Deng, Jianjian Han, Yong Xie, Kai Bao, Lixin Ma, Lilong Liu, Wuxiang Mao   +7 more
wiley   +1 more source

Screening of bacterial molecules with antagonistic or adjuvant activity [PDF]

, 2010
The Lipopolysaccharides (LPSs) are the major constituents of the outer membrane of Gram-negative bacteria and the interest in their chemical characterization is motivated by the close correlation existing between the structure and the biological activity
Fregolino, Eleonora
core  

Nanobodies as potential tools for microbiological testing of live biotherapeutic products

AMB Express
Nanobodies are highly specific binding domains derived from naturally occurring single chain camelid antibodies. Live biotherapeutic products (LBPs) are biological products containing preparations of live organisms, such as Lactobacillus, that are ...
Robert J. Dorosky, Jeremy E. Schreier, Stephanie L. Lola, Rosa L. Sava, Michael P. Coryell, Adovi Akue, Mark KuKuruga, Paul E. Carlson, Sheila M. Dreher-Lesnick, Scott Stibitz   +9 more
doaj   +1 more source

Establishment and optimization of an E. coli urinary tract infection model in Göttingen minipigs with strain recovery and characterization

Frontiers in Immunology
IntroductionUrinary tract infections caused by uropathogenic E. coli (UPEC) affect millions of individuals worldwide. Existing animal models used to study UTI treatment or vaccine efficacy have limitations and cannot accurately predict efficacy in humans.
Joyce Lübbers, Kaila Orlandini, Emily Podob, Jeffrey Fernandez, Jolaine M Wilson, Marjolein van Heerden, Jeroen Zeijpveld, Joan van Kregten, Peter T. Buckley, Germie van den Dobbelsteen, Kirsten L. Bair   +10 more
doaj   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Discriminator‐Guided Inverse Folding for Multi‐Property Protein Design

Advanced Science, EarlyView.
Discriminator‐Guided Inverse Folding (DGIF) integrates multiple property predictors trained from single‐property datasets to guide protein sequence generation from a backbone structure. DGIF enables simultaneous improvement of thermostability and solubility without requiring multi‐property annotated datasets and generates designs that move toward the ...
Yuchuan Zheng, Chuyi Liu, Zhaoming Liu, Mao Su, Chenyu Tang, Xiang Zheng, Hao Zhang, Jingyuan Li   +7 more
wiley   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

Towards integrated control of East Cost fever, a devastating disease of cattle [PDF]

, 2013
Infection of cattle with the tick-borne apicomplexan parasite Theileria parva results in the fatal lympho-proliferative disease known as East Coast fever (ECF).
Olds, Cassandra Leah
core   +1 more source