Results 81 to 90 of about 1,154,986 (294)

Engineering Human Donor Derived Germinal Center‐Like Organoids (GCLOs) for Studying Immune Response to Vaccination

Advanced Science, EarlyView.
We bioengineered a new approach methodology of generating Germinal Center Organoids that self‐organize from human blood‐derived immune cells. These immune organoids reproduce key features of humoral immunity, IgG production, and plasmablast emergence.
Bhumi Suthar, Carlos Gomez, Giancarlo Asencio, Suresh Pallikkuth, Ashutosh Agarwal   +4 more
wiley   +1 more source

Nanobodies as potential tools for microbiological testing of live biotherapeutic products

AMB Express
Nanobodies are highly specific binding domains derived from naturally occurring single chain camelid antibodies. Live biotherapeutic products (LBPs) are biological products containing preparations of live organisms, such as Lactobacillus, that are ...
Robert J. Dorosky, Jeremy E. Schreier, Stephanie L. Lola, Rosa L. Sava, Michael P. Coryell, Adovi Akue, Mark KuKuruga, Paul E. Carlson, Sheila M. Dreher-Lesnick, Scott Stibitz   +9 more
doaj   +1 more source

Establishment and optimization of an E. coli urinary tract infection model in Göttingen minipigs with strain recovery and characterization

Frontiers in Immunology
IntroductionUrinary tract infections caused by uropathogenic E. coli (UPEC) affect millions of individuals worldwide. Existing animal models used to study UTI treatment or vaccine efficacy have limitations and cannot accurately predict efficacy in humans.
Joyce Lübbers, Kaila Orlandini, Emily Podob, Jeffrey Fernandez, Jolaine M Wilson, Marjolein van Heerden, Jeroen Zeijpveld, Joan van Kregten, Peter T. Buckley, Germie van den Dobbelsteen, Kirsten L. Bair   +10 more
doaj   +1 more source

Improving cellular cancer vaccines [PDF]

, 2010
Immunization with cancer cells is of great demand in anti-cancer therapy. However, current cellular vaccines are inefficient and there are questions regarding their overall safety. We report a simple and straightforward approach for improving of cellular
Petr Lokhov
core  

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

A Glucose Metabolism‐Modulatory Nanobiohybrid Vaccine Platform Promotes Anti‐Tumor Immunity by Orchestrating Autophagy‐Dependent Cross‐Presentation and H2S‐Enhanced NLRP3 Inflammasome Signaling

Advanced Science, EarlyView.
A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang, Yimin Gong, Jianing Li, Tianze Wu, Mingli Deng, Yannan Yang   +5 more
wiley   +1 more source

Monitoring the introduction of pneumococcal conjugate vaccines into West Africa: design and implementation of a population-based surveillance system. [PDF]

, 2012
Routine use of pneumococcal conjugate vaccines (PCVs) in developing countries is expected to lead to a significant reduction in childhood deaths. However, PCVs have been associated with replacement disease with non-vaccine serotypes.
Greenwood, Brian M, Wattiaux Andre, Stephen R C Howie, Effua Usuf, Sambou Sana, Plumb Ian D., Uchendu, Uchendu, Wattiaux, Andre, Maria Deloria Knoll, Howie Stephen R. C., Saha, Debasish, Ian D Plumb, Philip C Hill, Howie, Stephen RC, Ikumapayi Usman N., Mackenzie Grant A., Lee Ellen, Jasseh, Momodou, Greenwood Brian M., Sana Sambou, Debasish Saha, Akinsola, Bolanle, Ellen Lee, Hill, Philip C, Brian M Greenwood, Jasseh Momodou, Adegbola, Richard A, Plumb, Ian D, Hill Philip C., Akinsola Bolanle, Kebba Touray, Uchendu Uchendu, Baldeh Ignatius, Usman N Ikumapayi, Ikumapayi, Usman N, Touray, Kebba, Levine, Orin S, Orin S Levine, Usuf Effua, Lee, Ellen, Ignatius Baldeh, Richard A Adegbola, Bolanle Akinsola, Saha Debasish, Momodou Jasseh, Sambou, Sana, Levine Orin S., Grant A Mackenzie, Knoll, Maria Deloria, Andre Wattiaux, Baldeh, Ignatius, Mackenzie, Grant A, Knoll Maria Deloria, Adegbola Richard A., Touray Kebba, Usuf, Effua   +55 more
core   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Immunity to Sexually Transmitted Bacterial Infections of the Female Genital Tract: Toward Effective Vaccines

Sexually transmitted infections (STIs) caused by bacterial pathogens Chlamydia trachomatis, Neisseria gonorrhoeae, and Treponema pallidum present significant public health challenges.
Kacy S. Yount, Toni Darville
core   +1 more source

Identification of protective antigens for vaccination against systemic salmonellosis [PDF]

, 2014
There is an urgent medical need for improved vaccines with broad serovar coverage and high efficacy against systemic salmonellosis. Subunit vaccines offer excellent safety profiles but require identification of protective antigens, which remains a ...
Dirk eBumann, Bumann, Dirk, Dirk Bumann
core   +1 more source