Results 61 to 70 of about 1,232,742 (295)

Changes in serogroup and genotype prevalence among carried meningococci in the United Kingdom during vaccine implementation [PDF]

, 2011
Natural fluctuations in carried meningococcal genotypes and phenotypes a can be affected by the use of conjugate vaccines, and not all of these changes are anticipatable in advance of vaccine ...
McCarthy, Noel D., Maclennan, Jenny, Evans, Meirion R, Rachel Urwin, Cameron, J. Claire, Neal, Keith R, Nicholas J. Andrews, Stuart C. Clarke, Cann, Kathryn, Noel D. McCarthy, Cameron, JC, Evans, MR, James M. Stuart, Harrison, S, Ala'aldeen, Dlawer, Cunningham, Richard, Martin C. J. Maiden, Jolley, Keith A, Derrick W. Crook, Dlawer Ala'Aldeen, Walker, AM, Baxter, David, Gray, Stephen J., Urwin, R, Crook, Derrick W., Keith R. Neal, Clarke, SC, Clarke, Stuart C, Maiden, Martin C. J., Jolley, Keith A., Stuart, James M., Maiden, Martin CJ, Keith A. Jolley, Kaczmarski, E, Walker, A. Mark, J. Simon Kroll, Richard Cunningham, Andrews, NJ, J. Claire Cameron, Crook, DW, Evans, Meirion Rhys, Harrison, Sarah, Andrews, Nicholas J, Edward Kaczmarski, Baxter, D, McCarthy, Noel D, Cann, K, Crook, Derrick W, Kathryn Cann, Ibarz-Pavón, Ana Belén, Clarke, Stuart C., Evans, Meirion R., A. Mark Walker, Cunningham, R, Kroll, J. Simon, Kroll, J Simon, Neal, KR, Cameron, J Claire, Maiden, MCJ, Andrews, Nicholas J., Neal, Keith R., McCarthy, ND, Stephen J. Gray, Jenny MacLennan, Meirion R. Evans, Urwin, Rachel, Stuart, James M, Stuart, JM, Sarah Harrison, Gray, SJ, Gray, Stephen J, Ana Belén Ibarz-Pavón, Walker, A Mark, Kaczmarski, Edward, David Baxter, Kroll, JS, Jolley, KA, Ala'Aldeen, D, MacLennan, J, Ibarz-Pavon, AB   +79 more
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Development of Phage Lysin LysA2 for Use in Improved Purity Assays for Live Biotherapeutic Products

Viruses, 2015
Live biotherapeutic products (LBPs), commonly referred to as probiotics, are typically preparations of live bacteria, such as Lactobacillus and Bifidobacterium species that are considered normal human commensals.
Sheila M. Dreher-Lesnick, Jeremy E. Schreier, Scott Stibitz   +2 more
doaj   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Clinical burden of invasive Escherichia coli disease among older adult patients treated in hospitals in the United States

BMC Infectious Diseases, 2023
Background Invasive extraintestinal pathogenic Escherichia coli disease (IED) can lead to severe outcomes, particularly among older adults. However, the clinical burden of IED in the U.S. has not been well characterized.
Luis Hernandez-Pastor, Jeroen Geurtsen, Bryan Baugh, Antoine C. El Khoury, Nnanya Kalu, Marjolaine Gauthier-Loiselle, Rebecca Bungay, Martin Cloutier, Michal Sarnecki, Elie Saade   +9 more
doaj   +1 more source

Potential Applications of Microparticulate-Based Bacterial Outer Membrane Vesicles (OMVs) Vaccine Platform for Sexually Transmitted Diseases (STDs): Gonorrhea, Chlamydia, and Syphilis

, 2022
Art. 1245, 11 S.Sexually transmitted diseases (STDs) are a major global health issue. Approximately 250 million new cases of STDs occur each year globally.
Uddin, M.N., Gala, R.P., Chbib, C., Shah, S.M.   +3 more
core   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

The Immunogenicity of Glutaraldehyde Inactivated PTx Is Determined by the Quantity of Neutralizing Epitopes

Vaccines
Background/Objectives: Chemically or genetically detoxified pertussis toxin (PTx) is a crucial antigen component of the acellular pertussis vaccine. Chemical detoxification using glutaraldehyde generally causes significant structural changes to the toxin.
Xi Wang, Xinyue Cui, Chongyang Wu, Ke Tao, Shuyuan Pan, Wenming Wei   +5 more
doaj   +1 more source

Biological safety concepts of genetically modified live bacterial vaccines

, 2007
Live vaccines possess the advantage of having access to induce cell-mediated and antibody-mediated immunity; thus in certain cases they are able to prevent infection, and not only disease. Furthermore, live vaccines, particularly bacterial live vaccines,
Frey, Joachim
core   +1 more source