Results 41 to 50 of about 1,154,986 (294)

A human Lyme disease vaccine: two steps forward on the path to prevention

Expert Review of Vaccines
Introduction Lyme disease is caused by the tick-borne spirochete pathogen Borrelia burgdorferi sensu lato (s.l.). Outer surface protein A (OspA) is expressed by B. burgdorferi s.l.
Raphael Simon, Erik Lamberth, James H. Stark, Julie M. Skinner   +3 more
doaj   +1 more source

Target identification for prevention and therapy of "Salmonella" infections [PDF]

, 2014
In this thesis we investigated maintenance requirements of Salmonella during chronic infections, and determined the relevant antigen properties that might facilitate the development of Salmonella vaccines. Overall, we wanted to achieve two goals: a)To
Barat, Somedutta
core   +1 more source

Bacterial Spores as Vaccine Vehicles [PDF]

Infection and Immunity, 2003
ABSTRACT For the first time, bacterial spores have been evaluated as vaccine vehicles. Bacillus subtilis spores displaying the tetanus toxin fragment C (TTFC) antigen were used for oral and intranasal immunization and were shown to generate mucosal and systemic responses in a murine model.
DUC L. H., HUYNH H. A., FAIRWEATHER N., RICCA, EZIO, CUTTING S. M.   +4 more
openaire   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A SpA+LukAB vaccine targeting Staphylococcus aureus evasion factors restricts infection in two minipig infection models

npj Vaccines
Staphylococcus aureus is a major cause of bacterial infection-related deaths. Increasing antimicrobial resistance highlights the urgent need for effective preventative strategies.
Jan T. Poolman, Victor J. Torres, Dominique Missiakas, Suzanne P. M. Welten, Jeffrey Fernandez, Ashley L. DuMont, Anna O’Keeffe, Sergey R. Konstantinov, Brian Morrow, Peter Burghout, Jan Grijpstra, Miranda M. C. van Beers, Chakkumkal Anish, Michel Beurret, Jeroen Geurtsen, Pauline M. L. Rood, Oliver Koeberling, Miaomiao Shi, Germie P. J. M. van den Dobbelsteen   +18 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Toward an Improved Meningococcal Serogroup B Assay

mBio, 2018
Because of diverse sequences and differential expression of surface structures on individual invasive Neisseria meningitidis serogroup B (MenB) strains, predicting the efficacy of MenB vaccines using traditional human serum bactericidal assays (hSBA) is ...
Jan Poolman
doaj   +1 more source

Vaccines against bacterial meningitis [PDF]

British Medical Bulletin, 2004
Meningitis remains an important cause of morbidity and mortality among children >5 years of age and is especially prevalent in developing countries. Effective routine immunization against Hib, pneumococcus and serogroupC meningococcus has had a significant impact on both invasive disease and carriage caused by these encapsulated bacteria.
Segal, S, Pollard, A
openaire   +3 more sources

New drugs and vaccines for drug-resistant Mycobacterium tuberculosis infections [PDF]

, 2008
Tuberculosis remains the most common cause of death due to a single infective organism. Despite the availability of a vaccine and chemotherapeutic options, the global disease burden remains relatively unaffected.
Willcox, Benjamin, Gurdyal S Besra, Bhatt, Apoorva; id_orcid, Dover, LG, Apoorva Bhatt, Dover, Lynn, Besra, Gurdyal; id_orcid, Besra, Gurdyal, Bhatt, Apoorva, Lynn G Dover, Bhowruth, Veemal, Veemal Bhowruth, Benjamin E Willcox   +12 more
core   +1 more source

Acknowledgment to Reviewers of Vaccines in 2020

, 2021
Peer review is the driving force of journal development, and reviewers are gatekeepers who ensure that Vaccines maintains its standards for the high quality of its published papers [...
Vaccines Editorial Office Vaccines Editorial Office
core   +1 more source