Results 41 to 50 of about 129,985 (296)

Q Fever Vaccine Development: Current Strategies and Future Considerations

Pathogens, 2021
Q fever is a zoonotic disease caused by the intracellular pathogen Coxiella burnetii. This disease typically manifests as a self-limiting, febrile illness known as acute Q fever.
Carrie Mae Long
doaj   +1 more source

Immunity to Sexually Transmitted Bacterial Infections of the Female Genital Tract: Toward Effective Vaccines [PDF]

Sexually transmitted infections (STIs) caused by bacterial pathogens Chlamydia trachomatis, Neisseria gonorrhoeae, and Treponema pallidum present significant public health challenges.
Kacy S. Yount, Toni Darville
core   +1 more source

Development of vaccines against burkholderia pseudomallei. [PDF]

, 2011
Burkholderia pseudomallei is a Gram-negative bacterium which is the causative agent of melioidosis, a disease which carries a high mortality and morbidity rate in endemic areas of South East Asia and Northern Australia.
Patel, Natasha, Easton, Anna, Easton, A, Richard W. Titball, Anna eEaston, Gregory J Bancroft, Natasha Patel, Conejero, L, De Reynal, Melanie, Titball, Richard W, Richard W Titball, Conejero, Laura, Natasha ePatel, De Reynal, M, Bancroft, GJ, Anna Easton, Laura Conejero, Bancroft, Gregory J, Laura eConejero, Titball, RW, Melanie eDeReynal, Patel, N, Gregory J. Bancroft, Melanie De Reynal   +23 more
core   +1 more source

A human Lyme disease vaccine: two steps forward on the path to prevention

Expert Review of Vaccines
Introduction Lyme disease is caused by the tick-borne spirochete pathogen Borrelia burgdorferi sensu lato (s.l.). Outer surface protein A (OspA) is expressed by B. burgdorferi s.l.
Raphael Simon, Erik Lamberth, James H. Stark, Julie M. Skinner   +3 more
doaj   +1 more source

Recent advances in lipopolysaccharide-based glycoconjugate vaccines [PDF]

, 2021
Introduction The public health burden caused by pathogenic Gram-negative bacteria is increasingly prominent due to antimicrobial resistance. The surface carbohydrates are potential antigens for vaccines against Gram-negative bacteria.
Pollard, Andrew J, Rollier, Christine S, Pollard, Andrew, Zhu, Henderson, ROLLIER, CHRISTINE   +4 more
core   +2 more sources

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Identification of protective antigens for vaccination against systemic salmonellosis [PDF]

, 2014
There is an urgent medical need for improved vaccines with broad serovar coverage and high efficacy against systemic salmonellosis. Subunit vaccines offer excellent safety profiles but require identification of protective antigens, which remains a ...
Dirk eBumann, Bumann, Dirk, Dirk Bumann
core   +1 more source

A SpA+LukAB vaccine targeting Staphylococcus aureus evasion factors restricts infection in two minipig infection models

npj Vaccines
Staphylococcus aureus is a major cause of bacterial infection-related deaths. Increasing antimicrobial resistance highlights the urgent need for effective preventative strategies.
Jan T. Poolman, Victor J. Torres, Dominique Missiakas, Suzanne P. M. Welten, Jeffrey Fernandez, Ashley L. DuMont, Anna O’Keeffe, Sergey R. Konstantinov, Brian Morrow, Peter Burghout, Jan Grijpstra, Miranda M. C. van Beers, Chakkumkal Anish, Michel Beurret, Jeroen Geurtsen, Pauline M. L. Rood, Oliver Koeberling, Miaomiao Shi, Germie P. J. M. van den Dobbelsteen   +18 more
doaj   +1 more source

Toward an Improved Meningococcal Serogroup B Assay

mBio, 2018
Because of diverse sequences and differential expression of surface structures on individual invasive Neisseria meningitidis serogroup B (MenB) strains, predicting the efficacy of MenB vaccines using traditional human serum bactericidal assays (hSBA) is ...
Jan Poolman
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source