Results 31 to 40 of about 1,232,742 (295)

Development of Streptococcus pneumoniae Vaccines Using Live Vectors [PDF]

, 2014
: Streptococcus pneumoniae still causes severe morbidity and mortality worldwide, especially in young children and the elderly. Much effort has been dedicated to developing protein-based universal vaccines to conquer the current shortcomings of capsular ...
Roy Curtiss III, Shifeng Wang
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A SpA+LukAB vaccine targeting Staphylococcus aureus evasion factors restricts infection in two minipig infection models

npj Vaccines
Staphylococcus aureus is a major cause of bacterial infection-related deaths. Increasing antimicrobial resistance highlights the urgent need for effective preventative strategies.
Jan T. Poolman, Victor J. Torres, Dominique Missiakas, Suzanne P. M. Welten, Jeffrey Fernandez, Ashley L. DuMont, Anna O’Keeffe, Sergey R. Konstantinov, Brian Morrow, Peter Burghout, Jan Grijpstra, Miranda M. C. van Beers, Chakkumkal Anish, Michel Beurret, Jeroen Geurtsen, Pauline M. L. Rood, Oliver Koeberling, Miaomiao Shi, Germie P. J. M. van den Dobbelsteen   +18 more
doaj   +1 more source

Development and validation of a high-throughput agglutination assay for O-serogrouping clinical Escherichia coli isolates

Microbiology Spectrum
Accurate O-serotyping of Escherichia coli remains essential for clinical surveillance, outbreak investigation, and evaluation of vaccines targeting invasive E. coli disease.
Ritu Shastry, Wenchi Shang, Sarah Janssen, Sarah Tete, Elizabeth Garcia Dominguez, Germie van den Dobbelsteen, Todd Davies, Brian Morrow   +7 more
doaj   +1 more source

Bacterial Spores as Vaccine Vehicles [PDF]

Infection and Immunity, 2003
ABSTRACT For the first time, bacterial spores have been evaluated as vaccine vehicles. Bacillus subtilis spores displaying the tetanus toxin fragment C (TTFC) antigen were used for oral and intranasal immunization and were shown to generate mucosal and systemic responses in a murine model.
DUC L. H., HUYNH H. A., FAIRWEATHER N., RICCA, EZIO, CUTTING S. M.   +4 more
openaire   +3 more sources

Detection of Bacterial Contamination in Imported Live Poultry Vaccines to Egypt in 2018 [PDF]

, 2020
The vaccine is one of the most important biological products used in the poultry industry, thus it must be safe, potent, and effective. This work presents the results of a large-scale diagnostic survey performed in Egypt to study hygienic epidemiology ...
Elkamshishi, M. M., Ibrahim, H. H., Ibrahim, H. M.   +2 more
core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Q Fever Vaccine Development: Current Strategies and Future Considerations

Pathogens, 2021
Q fever is a zoonotic disease caused by the intracellular pathogen Coxiella burnetii. This disease typically manifests as a self-limiting, febrile illness known as acute Q fever.
Carrie Mae Long
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Validation of electrochemiluminescent (ECL)-based immunoassay to determine the levels of antibodies against Escherichia coli O-lipopolysaccharide antigens

Microbiology Spectrum
Extra-intestinal pathogenic Escherichia coli (ExPEC) is a significant cause of invasive infections, including urinary tract infections, neonatal meningitis, and bacteremia.
Maanan Kamdar, Vichiksha Shah, Sarah Janssen, Elizabeth Garcia Dominguez, Todd Davies, Germie van den Dobbelsteen   +5 more
doaj   +1 more source