Results 21 to 30 of about 1,232,742 (295)

Bacterial outer membrane vesicles and vaccine applications [PDF]

open access: yes, 2014
Vaccines based on outer membrane vesicles (OMV) were developed more than 20 years ago against Neisseria meningitidis serogroup B. These nano-sized structures exhibit remarkable potential for immunomodulation of immune responses and delivery of “self ...
Jose Luis Perez   +30 more
core   +3 more sources

Recent advances in lipopolysaccharide-based glycoconjugate vaccines [PDF]

open access: yes, 2021
Introduction The public health burden caused by pathogenic Gram-negative bacteria is increasingly prominent due to antimicrobial resistance. The surface carbohydrates are potential antigens for vaccines against Gram-negative bacteria.
Pollard, Andrew   +5 more
core   +1 more source

Target identification for prevention and therapy of "Salmonella" infections [PDF]

open access: yes, 2014
In this thesis we investigated maintenance requirements of Salmonella during chronic infections, and determined the relevant antigen properties that might facilitate the development of Salmonella vaccines. Overall, we wanted to achieve two goals: a)To
Barat, Somedutta
core   +1 more source

Assembly, Biochemical Characterization, Immunogenicity, Adjuvanticity, and Efficacy of Shigella Artificial Invaplex

open access: yesmSphere, 2018
The native Invaplex (InvaplexNAT) vaccine and adjuvant is an ion exchange-purified product derived from the water extract of virulent Shigella species.
K. Ross Turbyfill   +4 more
doaj   +1 more source

Efficacy, safety, and immunogenicity of the Shigella sonnei 1790GAHB GMMA candidate vaccine: Results from a phase 2b randomized, placebo-controlled challenge study in adults

open access: yesEClinicalMedicine, 2021
Background: Shigellosis accounts for substantial morbidity and mortality worldwide and is the second most common cause of moderate and severe diarrhoea in children.
Robert W. Frenck, Jr   +23 more
doaj   +1 more source

Isolation, identification, and monitoring of antibiotic resistance in Pasteurella multocida and Mannheimia haemolytica isolated from sheep in East Azerbaijan province, Iran [PDF]

open access: yesArchives of Razi Institute, 2016
The present study was carried out in order to isolate, identify, and assess the antimicrobial susceptibility of the causative agent(s) of pneumonic pasteurellosis in sheep in East Azerbaijan province, northwest of Iran.
I. Khalili   +6 more
doaj   +1 more source

BACTERIAL VACCINE THERAPY [PDF]

open access: yesJournal of the American Medical Association, 1917
"If at the present time ten years of public notoriety have passed over any doctrine professing to be of importance in medical science, and if it has not succeeded in raising up a powerful body of able, learned, and ingenious advocates for its claims, the fault must be in the doctrine and not in the medical profession." This old criterion of Holmes is ...
openaire   +2 more sources

Features of intellectual property protection mechanisms on the example of orphan drugs circulation

open access: yesФармакоэкономика, 2022
Objective: to study features of intellectual property protection mechanisms on the example of drugs for the treatment of rare (orphan) diseases.Material and methods.
D. S. Yurochkin   +4 more
doaj   +1 more source

Vaccines against bacterial meningitis [PDF]

open access: yesBritish Medical Bulletin, 2004
Meningitis remains an important cause of morbidity and mortality among children >5 years of age and is especially prevalent in developing countries. Effective routine immunization against Hib, pneumococcus and serogroupC meningococcus has had a significant impact on both invasive disease and carriage caused by these encapsulated bacteria.
Segal, S, Pollard, A
openaire   +3 more sources

A human Lyme disease vaccine: two steps forward on the path to prevention

open access: yesExpert Review of Vaccines
Introduction Lyme disease is caused by the tick-borne spirochete pathogen Borrelia burgdorferi sensu lato (s.l.). Outer surface protein A (OspA) is expressed by B. burgdorferi s.l.
Raphael Simon   +3 more
doaj   +1 more source

Home - About - Disclaimer - Privacy