Results 21 to 30 of about 129,578 (294)

The Evolution of Vaccines Development across Salmonella Serovars among Animal Hosts: A Systematic Review

open access: yesVaccines
Salmonella is a significant zoonotic foodborne pathogen, and the global spread of multidrug-resistant (MDR) strains poses substantial challenges, necessitating alternatives to antibiotics.
Abubakar Siddique   +9 more
doaj   +2 more sources

Epitope-Based Vaccines: The Next Generation of Promising Vaccines Against Bacterial Infection

open access: yesVaccines
The increasing resistance of bacteria to antibiotics has underscored the need for new drugs or vaccines to prevent bacterial infections. Reducing multidrug resistance is a key objective of the WHO’s One Health initiative. Epitopes, the key parts of
, Yang Xiao-Yan
exaly   +2 more sources

Combined effects of glycan chain length and linkage type on the immunogenicity of glycoconjugate vaccines

open access: yesnpj Vaccines, 2021
The development and use of antibacterial glycoconjugate vaccines have significantly reduced the occurrence of potentially fatal childhood and adult diseases such as bacteremia, bacterial meningitis, and pneumonia.
Chakkumkal Anish   +2 more
doaj   +1 more source

Clinical trial of tolerability, safety, and immunogenicity of the Russian influenza inactivated split vaccine Flu-m in children from 6 months to 9 years of age

open access: yesЖурнал инфектологии, 2023
Purpose: To study the reactogenicity, safety and immunogenicity of the Russian vaccine Flu-M in comparison with Vaxigrip vaccine for influenza prevention in children aged from 6 months to 9 years (phase III).Materials and Methods.
A. M. Korolyuk   +8 more
doaj   +1 more source

IMMUNOGENICITY OUTCOMES OF A RANDOMIZED, MULTICENTER, INTERVENTIONAL, FIRST-IN-HUMAN, PHASE 1/2A STUDY OF VAC52416 (EXPEC10V), A VACCINE CANDIDATE FOR THE PREVENTION OF INVASIVE ESCHERICHIA COLI DISEASE

open access: yesInternational Journal of Infectious Diseases, 2023
Intro: The safety, reactogenicity, and immunogenicity of VAC52416 (ExPEC10V), a vaccine candidate to prevent invasive Escherichia coli disease, was assessed in a phase 1/2a study (NCT03819049). Results from Cohort 1 have been presented. Here, we describe
C. Fierro   +9 more
doaj   +1 more source

Composing of an oil adjuvant containing BCG as an immunomodulating for rabbit clostridial enterotoxaemia and bloat vaccine [PDF]

open access: yesVeterinary Medical Journal - Giza, 2022
Clostridium perfringens (C. perfringens) is one of the most important pathogen that is widely distributed in all over the world and responsible for many diseases among life stock.
Hamed ElHelw   +4 more
doaj   +1 more source

Chikungunya vaccines: advances in the development and prospects for marketing approval

open access: yesБиопрепараты: Профилактика, диагностика, лечение, 2023
Chikungunya fever is an acute infectious disease caused by the mosquito-borne Chikungunya virus (CHIKV). In the last decades, cases of the disease have been reported in more than 100 countries; therefore, CHIKV presents a global public health problem ...
E. V. Otrasheuskaja   +3 more
doaj   +1 more source

Low-Energy Electron Irradiation (LEEI) for the Generation of Inactivated Bacterial Vaccines

open access: yes, 2021
S.97-113Vaccines consisting of whole inactivated bacteria (bacterins) are generated by incubation of the pathogen with chemicals. This is a time-consuming procedure which may lead to less immunogenic material, as critical antigenic structures can be ...
Sebastian Ulbert   +11 more
core   +1 more source

High dissolved oxygen tension triggers outer membrane vesicle formation by Neisseria meningitidis

open access: yesMicrobial Cell Factories, 2018
Background Outer membrane vesicles (OMVs) are nanoparticles released by Gram-negative bacteria and can be used as vaccines. Often, detergents are used to promote release of OMVs and to remove the toxic lipopolysaccharides.
Matthias J. H. Gerritzen   +6 more
doaj   +1 more source

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