Results 201 to 210 of about 129,985 (296)

Recent progress on the development of hydrogel‐based microneedles for transdermal drug delivery

VIEW, EarlyView.
This study provides a comprehensive and up‐to‐date analysis of recent progress in HMN technology, covering fundamental transdermal delivery mechanisms and design principles, biomaterials used in HMN fabrication, drug loading and release strategies, and emerging therapeutic applications.
Mohammad Muhtasim Ittisaf, Salman Farsi Taharat, Md. Sadek Miah, Hasan Tasnim Salehin, M. Azam Ali, Shoeb Ahmed   +5 more
wiley   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

<i>Bordetella pertussis</i> Infection: From Immune Pathogenesis to Next-Generation Vaccines. [PDF]

Vaccines (Basel)
Georgakopoulou VE, Pitiriga VC.
europepmc   +1 more source

Cellular Mechanism and Key Insights in Allergen Immunotherapy for Allergic Rhinitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Allergic rhinitis (AR) arises from immune responses mediated by immunoglobulin E (IgE) to inhaled allergens, representing one of the most prevalent chronic conditions worldwide. Although AR may not be a serious ailment, it holds clinical relevance as it underpins numerous complications, serves as a major risk factor for suboptimal asthma ...
Zhe Wang, Teng‐Fei Li, Tian‐Yu Wang, Huan‐Hai Liu   +3 more
wiley   +1 more source

Meningococcal Vaccines Work Group update [PDF]

core   +6 more sources

<i>Avibacterium paragallinarum</i>: Pathogenesis Mechanisms and Subunit Vaccine Development. [PDF]

Microorganisms
Li Z, Liu Y, Liu Z, Jiang Z, Wang Y, Xing B, Mei C, Wang H.   +7 more
europepmc   +1 more source

Leukocyte profiles reveal sex and age differences in immune investment in a polygynous bat

Journal of Animal Ecology, EarlyView.
Analysis of over 500 blood cell profiles, including repeat samples over four years, reveals that male bats from a long‐lived species with a polygynous mating system invest more in innate than adaptive immunity. Investment in innate immunity increases with age, as estimated by a DNA methylation clock and mark‐recapture data.
Gerald S. Wilkinson, Jillian A. Kaiser, Katherine N. Armenta, Ana S. G. Cunningham, Severine B. S. W. Hex, Alexis M. Lawson, Jack G. Rayner   +6 more
wiley   +1 more source

Maltase 1 regulates DENV2 infection and life history in Aedes aegypti

Insect Science, EarlyView.
Our study employed CRISPR/Cas9 to generate a MAL1 knockout strain of Aedes aegypti, demonstrating that the absence of MAL1 significantly suppresses DENV2 replication in the midgut and impairs viral transmission. The mutation also altered life‐history (hatching/pupation/emerging rates and sex‐specific survival), identifying MAL1 as a novel target for ...
Man‐Jin Li, Jin Cheng, Ya‐Ming Zou, Quan‐Chao Liu, Ding Zhu, Ce‐Jie Lan   +5 more
wiley   +1 more source

Mechanisms of natural and vaccine-induced immunity to Bordetella pertussis. [PDF]

PLoS Pathog
Borkner L, Sutton CE, Udayan S, Jazayeri SD, Mills KHG.   +4 more
europepmc   +1 more source

Text mining for case report articles on “peritoneal dialysis” from PubMed database

Therapeutic Apheresis and Dialysis, Volume 29, Issue 3, Page 459-470, June 2025.
Abstract Introduction The number of published medical articles on peritoneal dialysis (PD) has been increasing, and efficiently selecting information from numerous articles can be difficult. In this study, we examined whether artificial intelligence (AI) text mining can be a good support for efficiently collecting PD information.
Kazuhiko Fukushima, Kenji Tsuji, Hiroyuki Nakanoh, Naruhiko Uchida, Soichiro Haraguchi, Shinji Kitamura, Jun Wada   +6 more
wiley   +1 more source