Inactivation of tomato WAT1 leads to reduced susceptibility to Clavibacter michiganensis through downregulation of bacterial virulence factors [PDF]
Frontiers in Plant Science, 2023 Tomato bacterial canker caused by Clavibacter michiganensis (Cm) is considered to be one of the most destructive bacterial diseases of tomato. To date, no resistance to the pathogen has been identified. While several molecular studies have identified (Cm)
Eleni Koseoglou +7 more
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Bacterial Virulence Factors: Secreted for Survival. [PDF]
Indian J Microbiol, 2017 Virulence is described as an ability of an organism to infect the host and cause a disease. Virulence factors are the molecules that assist the bacterium colonize the host at the cellular level. These factors are either secretory, membrane associated or cytosolic in nature.
Sharma AK +6 more
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Bacterial virulence factors: a target for heterocyclic compounds to combat bacterial resistance. [PDF]
RSC Adv, 2021 This review presents an overview of different heterocyclic compounds that act as anti-virulence agents in order to overcome microbial resistance.
Abd El-Aleam RH +3 more
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The Epistemology of Bacterial Virulence Factor Characterization
MicroorganismsThe field of microbial pathogenesis seeks to identify the agents and mechanisms responsible for disease causation. Since Robert Koch introduced postulates that were used to guide the characterization of microbial pathogens, technological advances have ...
Matthew Jackson +2 more
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The Composition and Spatial Patterns of Bacterial Virulence Factors and Antibiotic Resistance Genes in 19 Wastewater Treatment Plants. [PDF]
PLoS ONE, 2016 Bacterial pathogenicity and antibiotic resistance are of concern for environmental safety and public health. Accumulating evidence suggests that wastewater treatment plants (WWTPs) are as an important sink and source of pathogens and antibiotic ...
Bing Zhang +6 more
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Mechanisms of Oral Bacterial Virulence Factors in Pancreatic Cancer. [PDF]
Front Cell Infect Microbiol, 2019 سرطان البنكرياس هو مرض قاتل للغاية، ويظل معظم المرضى بدون أعراض حتى يدخل المرض في مراحل متقدمة. هناك نقص في المعرفة في التسبب والوقاية الفعالة والتشخيص المبكر لسرطان البنكرياس. في الآونة الأخيرة، تم العثور على البكتيريا في أنسجة البنكرياس التي كانت تعتبر معقمة من قبل.
Sun Z +5 more
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Granzyme B Attenuates Bacterial Virulence by Targeting Secreted Factors [PDF]
iScience, 2020 Summary: Pathogenic bacteria secrete virulence factors that interact with the human host to establish infections. The human immune system evolved multiple mechanisms to fight bacterial invaders, including immune proteases that were demonstrated to ...
Diego López León +7 more
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The Rab-binding Profiles of Bacterial Virulence Factors during Infection. [PDF]
J Biol Chem, 2016 Legionella pneumophila, the causative agent of Legionnaire's disease, uses its type IV secretion system to translocate over 300 effector proteins into host cells. These effectors subvert host cell signaling pathways to ensure bacterial proliferation.
So EC +7 more
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Targeting anti-virulence factor strategies of bacterial pathogens
Biosafety and HealthAntibiotic-resistant bacterial pathogens pose substantial biosafety and health hazards, leading to millions of deaths each year. The evolution of bacterial virulence factors is mainly propelled by horizontal gene transfer (HGT).
Jiashu Li, Tianyuan Jia, Liang Yang
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Virulence factors and quorum sensing as targets of new therapeutic options by plant-derived compounds against bacterial infections caused by human and animal pathogens [PDF]
Veterinary World, 2023 The emergence of antibiotic-resistant bacteria and hospital-acquired bacterial infection has become rampant due to antibiotic overuse. Virulence factors are secondary to bacterial growth and are important in their pathogenesis, and therefore, new ...
Warangkana Kitpipit +6 more
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