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Host and Bacterial Virulence Factors Predisposing to Emphysematous Pyelonephritis
American Journal of Kidney Diseases, 2005Emphysematous pyelonephritis (EPN) is a rare, severe, gas-forming infection of the kidney, and its precise pathogenesis remains obscure.To investigate the roles of host and bacterial virulence factors in the pathogenesis of EPN, we compared: (1) host factors in patients with EPN (n = 47) with those in patients with acute renal infections without gas ...
Chin-Chung, Tseng +5 more
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A bacterial virulence factor that dissipates tension
Nature Cell Biology, 2009Various microbes harness the actin polymerization machinery through their surface proteins to allow intracellular motility within host cells, but other virulence factors regulate dissemination. The cortical actin tension of polarized cells may represent a physical barrier that hinders the formation of microbial protrusions during cell-to-cell spreading.
Stéphane Romero, Guy Tran Van Nhieu
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2017
What is a pathogen? What is a virulence factor? At one time, these were relatively straightforward questions to address. During the late nineteenth century, when Pasteur and Koch were developing the germ theory of disease, a pathogen was simply defined as a microorganism that was capable of causing disease in a host (only human hosts will be considered
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What is a pathogen? What is a virulence factor? At one time, these were relatively straightforward questions to address. During the late nineteenth century, when Pasteur and Koch were developing the germ theory of disease, a pathogen was simply defined as a microorganism that was capable of causing disease in a host (only human hosts will be considered
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Are bacterial proteases important virulence factors?
Journal of Periodontal Research, 1997The contribution of bacterial proteases to virulence has been relatively understudied. It is a simple matter to argue that bacterial proteases have the potential to destroy the structural and functional proteins that constitute host tissues as well as to destroy proteins important in host defense.
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In search of virulence factors of human bacterial disease
Trends in Microbiology, 1997Traditional genetic techniques and a variety of animal and tissue-culture model systems have sustained the study of bacterial virulence mechanisms for several decades. However, the recent application of newly developed molecular and cellular techniques has brought our understanding of bacterial pathogenesis to new heights by permitting the ...
F D, Quinn, G W, Newman, C H, King
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Bacteriuria, Bacterial Virulence and Host Factors in Diabetic Patients
Diabetic Medicine, 1993The prevalence of bacteriuria as well as bacterial virulence and host factors were studied in 514 diabetic outpatients and 405 nondiabetic controls. The prevalence of bacteriuria was not significantly higher in diabetic women (15/239, 6.3 %) than in age‐matched nondiabetic women (8/236, 3.4 %).
A, Brauner +3 more
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Bacterial Virulence Factors as Targets for Chemotherapy
1992Bacteria adapt to specific environments where they can grow and reproduce. When the niche is within a second organism, a bacterium may establish a commensal or even symbiotic relationship with the host. In some situations, however, a bacterium may cause damage or otherwise perturb the host, resulting in disease. Such bacteria are pathogens.
Sarah K. Highlander, George M. Weinstock
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Bacterial Cytolysins — Extracellular Proteins and Virulence Factors
1987Synthesis of hemolysis has been reported throughout a broad spectrum of gram-negative and gram-positive bacterial species. The in vitro action of hemolysins ultimately causes physical damage to a variety of eukaryotic cells. Bacterial products possessing such a membrane-damaging action have been termed cytolysins and for many of the hemolysins, a ...
S. Kathariou +6 more
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The Role of Bacterial Polysaccharide Capsules as Virulence Factors
1990Carbohydrates are universally present on the surface of living cells. On eukaryotic cells, many different carbohydrates are attached as glycoproteins and glycolipids; the oligosaccharide moieties are known to act as receptors and it seems likely that they play an important role in cell-to-cell recognition processes.
E R, Moxon, J S, Kroll
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[Detection of bacterial virulence factors].
Rinsho byori. The Japanese journal of clinical pathology, 1990Several newly developed methods, including immunological and DNA hybridization techniques, have been recently introduced in clinical diagnosis. Target molecules for these detection methods are either avirulent materials or virulence factors specific to the individual causative pathogen.
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