Results 31 to 40 of about 169,412 (160)

Is quorum sensing interference a viable alternative to treat Pseudomonas aeruginosa infections?

Frontiers in Microbiology, 2016
Quorum sensing (QS) coordinates the expression of multiple virulence factors in Pseudomonas aeruginosa; hence its inhibition has been postulated as a new alternative to treat its infections.
Rodolfo García-Contreras
doaj   +1 more source

Connections between Exoproteome Heterogeneity and Virulence in the Oral Pathogen Aggregatibacter actinomycetemcomitans

mSystems, 2022
Aggregatibacter actinomycetemcomitans is a Gram-negative bacterial pathogen associated with severe periodontitis and nonoral diseases. Clinical isolates of A.
Yanyan Fu, Sandra Maaβ, Marines du Teil Espina, Anouk H. G. Wolters, Yanan Gong, Anne de Jong, Erwin Raangs, Girbe Buist, Johanna Westra, Dörte Becher, Jan Maarten van Dijl   +10 more
doaj   +1 more source

A Structural Approach to Anti-Virulence: A Discovery Pipeline

Microorganisms, 2021
The anti-virulence strategy is designed to prevent bacterial virulence factors produced by pathogenic bacteria from initiating and sustaining an infection.
Michael McCarthy, Monica Goncalves, Hannah Powell, Blake Morey, Madison Turner, Allan Rod Merrill   +5 more
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Modulation of host biology by Pseudomonas aeruginosa quorum sensing signal molecules: messengers or traitors

Frontiers in Microbiology, 2015
Bacterial cells sense their population density and respond accordingly by producing various signal molecules to the surrounding environments thereby trigger a plethora of gene expression. This regulatory pathway is termed quorum sensing (QS).
Yi-Chia eLiu, Kok-Gan eChan, Chien-Yi eChang, Chien-Yi eChang   +3 more
doaj   +1 more source

Alternative Sigma Factors and Their Roles in Bacterial Virulence [PDF]

Microbiology and Molecular Biology Reviews, 2005
SUMMARY Sigma factors provide promoter recognition specificity to RNA polymerase holoenzyme, contribute to DNA strand separation, and then dissociate from the core enzyme following transcription initiation. As the regulon of a single sigma factor can be composed of hundreds of genes, sigma factors can provide ...
Mark J, Kazmierczak, Martin, Wiedmann, Kathryn J, Boor   +2 more
openaire   +2 more sources

Detection of the babA2 adhesin gene in Helicobacter pylori clinical isolates and correlation with upper gastrointestinal diseases [PDF]

Anais da Academia Brasileira de Ciências
Helicobacter pylori is an oncobacteria that infects more than half of the world’s population. Adhesins are virulence factors that are essential for the microorganism to bind to the gastric mucosa, such as the BabA adhesion protein, which is associated ...
DIOGO NERY MACIEL, SILVANA B. SANTIAGO, VIVIANE L. ROCHA, GABRIELA L. DOS SANTOS, LUCAS T. RASMUSSEN, MÔNICA S. BARBOSA   +5 more
doaj   +1 more source

Construction of a multiplex promoter reporter platform to monitor Staphylococcus aureus virulence gene expression and the identification of usnic acid as a potent suppressor of psm gene expression

Frontiers in Microbiology, 2016
As antibiotic resistance becomes phenomenal, alternative therapeutic strategies for bacterial infections such as anti-virulence treatments have been advocated.
Peng GAO, Peng GAO, Yanli Wang, Yanli Wang, Iván Villanueva, Pak Leung Ho, Pak Leung Ho, Pak Leung Ho, Julian Davies, Richard Yi Tsun KAO, Richard Yi Tsun KAO, Richard Yi Tsun KAO   +11 more
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Escherichia coli urinary tract infections: Host age-related differences in bacterial virulence factors and antimicrobial susceptibility

Journal of Microbiology, Immunology and Infection, 2022
Background: Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are one of the most common outpatient bacterial infections.
Wei-Hung Lin, Ming-Cheng Wang, Po-Yao Liu, Po-Shun Chen, Li-Li Wen, Ching-Hao Teng, Cheng-Yen Kao   +6 more
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Bacterial Protein Tyrosine Phosphatases as Possible Targets for Antimicrobial Therapies in Response to Antibiotic Resistance

Antioxidants, 2022
The review is focused on the bacterial protein tyrosine phosphatases (PTPs) utilized by bacteria as virulence factors necessary for pathogenicity. The inhibition of bacterial PTPs could contribute to the arrest of the bacterial infection process.
Alicja Kuban-Jankowska, Tomasz Kostrzewa, Magdalena Gorska-Ponikowska   +2 more
doaj   +1 more source

A comparison of computational methods for identifying virulence factors.

PLoS ONE, 2012
Bacterial pathogens continue to threaten public health worldwide today. Identification of bacterial virulence factors can help to find novel drug/vaccine targets against pathogenicity.
Lu-Lu Zheng, Yi-Xue Li, Juan Ding, Xiao-Kui Guo, Kai-Yan Feng, Ya-Jun Wang, Le-Le Hu, Yu-Dong Cai, Pei Hao, Kuo-Chen Chou   +9 more
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