Results 1 to 10 of about 109,646 (117)

Early bactericidal activity of sitafloxacin against pulmonary tuberculosis [PDF]

Microbiology Spectrum
Sitafloxacin is a quinolone broad-spectrum antimicrobial agent, and its pharmacologic properties and in vitro data demonstrate that sitafloxacin has a potent killing effect against Mycobacterium tuberculosis, including drug-resistant strains, which is ...
Lihui Nie, Jing Tong, Guihui Wu, Juan Du, Yuanyuan Shang, Yufeng Wang, Zhangjun Wu, Yuanhong Xu, Yi Ren, Youyi Rao, Yu Pang, Mengqiu Gao   +11 more
doaj   +2 more sources

Serum bactericidal activity against meningococcus in patients with systemic lupus erythematosus [PDF]

Clinical and Experimental Pediatrics
Background Patients with systemic lupus erythematosus (SLE) are susceptible to infectious diseases owing to various immunosuppressive treatments and disease characteristics.
Soyoung Lee, Kyung-Hyo Kim, Ji Hyen Lee, Han Wool Kim   +3 more
doaj   +2 more sources

Validation of the method for determining the specific activity of the gel with recombinant endolysin [PDF]

BIO Web of Conferences, 2021
A method for determining the specific bactericidal activity of the gel with the recombinant modified endolysin of the bacteriophage ECD7 has been developed.
Vorobev Alexey, Anurova Mariia, Bagandova Kalimat, Mizaeva Toita, Aleshkin Andrei, Vasina Daria, Antonova Natalia, Gushchin Vladimir   +7 more
doaj   +1 more source

In vitro Bactericidal Activities of Combination Antibiotic Therapies Against Carbapenem-Resistant Klebsiella pneumoniae With Different Carbapenemases and Sequence Types

Frontiers in Microbiology, 2021
Carbapenem-resistant Klebsiella pneumoniae (CRKP) is becoming increasingly problematic due to the limited effectiveness of new antimicrobials or other factors such as treatment cost. Thus, combination therapy remains a suitable treatment option. We aimed
Jocelyn Qi-Min Teo, Jocelyn Qi-Min Teo, Nazira Fauzi, Jayden Jun-Yuan Ho, Si Hui Tan, Shannon Jing-Yi Lee, Tze Peng Lim, Tze Peng Lim, Tze Peng Lim, Yiying Cai, Hong Yi Chang, Nurhayati Mohamed Yusoff, James Heng-Chiak Sim, Thuan Tong Tan, Rick Twee-Hee Ong, Andrea Lay-Hoon Kwa, Andrea Lay-Hoon Kwa, Andrea Lay-Hoon Kwa   +17 more
doaj   +1 more source

Standards for model-based early bactericidal activity analysis and sample size determination in tuberculosis drug development

Frontiers in Pharmacology, 2023
Background: A critical step in tuberculosis (TB) drug development is the Phase 2a early bactericidal activity (EBA) study which informs if a new drug or treatment has short-term activity in humans.
Laurynas Mockeliunas, Alan Faraj, Rob C. van Wijk, Caryn M. Upton, Gerben van den Hoogen, Andreas H. Diacon, Ulrika S. H. Simonsson   +6 more
doaj   +1 more source

Two major medicinal honeys have different mechanisms of bactericidal activity. [PDF]

PLoS ONE, 2011
Honey is increasingly valued for its antibacterial activity, but knowledge regarding the mechanism of action is still incomplete. We assessed the bactericidal activity and mechanism of action of Revamil® source (RS) honey and manuka honey, the sources of
Paulus H S Kwakman, Anje A Te Velde, Leonie de Boer, Christina M J E Vandenbroucke-Grauls, Sebastian A J Zaat   +4 more
doaj   +1 more source

Artemisia afra and Artemisia annua Extracts Have Bactericidal Activity against Mycobacterium tuberculosis in Physiologically Relevant Carbon Sources and Hypoxia

Pathogens, 2023
Mycobacterium tuberculosis (Mtb) is a deadly pathogen and causative agent of human tuberculosis, causing ~1.5 million deaths every year. The increasing drug resistance of this pathogen necessitates novel and improved treatment strategies.
Bushra Hafeez Kiani, Maria Natalia Alonso, Pamela J. Weathers, Scarlet S. Shell   +3 more
doaj   +1 more source

Mygalin: An Acylpolyamine With Bactericidal Activity

Frontiers in Microbiology, 2020
Inappropriate use of antibiotics favors the selection and spread of resistant bacteria. To reduce the spread of these bacteria, finding new molecules with activity is urgent and necessary.
Abraham Espinoza-Culupú, Abraham Espinoza-Culupú, Elizabeth Mendes, Hector Aguilar Vitorino, Pedro Ismael da Silva, Monamaris Marques Borges   +5 more
doaj   +1 more source

Glycerol monolaurate antibacterial activity in broth and biofilm cultures. [PDF]

PLoS ONE, 2012
Glycerol monolaurate (GML) is an antimicrobial agent that has potent activity against gram-positive bacteria. This study examines GML antibacterial activity in comparison to lauric acid, in broth cultures compared to biofilm cultures, and against a wide ...
Patrick M Schlievert, Marnie L Peterson
doaj   +1 more source

Electrochemical Studies on Bactericidal Mechanism of Human Lactoferrin and Its Demand for Microenvironment

International Journal of Electrochemical Science, 2017
The bactericidal mechanism of human lactoferrin (LF) was analyzed by employing bioelectrochemistry technique. The result showed that LF bound to lipopolysaccharides (LPS) and caused release of LPS, resulting in formation of ion channels in the mimic ...
Junyi Huang, Tao Liu, Jie Cao, Zhengjun Wu, Xian-yan Liao, Hong-sheng Song   +5 more
doaj   +1 more source