Advanced Science, EarlyView.A 3D‑printed multilayer adhesive scaffold, firmly anchored to bone defects by simple finger pressing, suppresses micromotion and secures mechanical stability of the osteogenic niche. This stabilization likely contributes to the enhanced bone augmentation by fostering a pro‑regenerative mechano‐immune profile—characterized by M2‑like macrophage ...
Delu Zhao +7 more
wiley +1 more source
Rapid Bactericidal Activity of <i>Punica granatum</i> L. Peel Extract: A Natural Alternative for Mastitis Prevention in Dairy Cattle. [PDF]
MoleculesSilva CREA +9 more
europepmc +1 more source
Advanced Science, EarlyView.eCIRP released in the stroke brain binds to TLR4 expressed on microglia to induce miR‐155, which suppresses MafB, decreases MerTK and downstream signaling to impair efferocytosis of apoptotic neurons, worsening the acute stroke outcomes. Inhibition of eCIRP‐TLR4 interaction with small peptide C23 attenuates eCIRP‐induced microglial efferocytic ...
Dmitriy Lapin +3 more
wiley +1 more source
A Simple In Vitro Method to Determine Bactericidal Activity Against <i>Mycobacterium abscessus</i> Under Hypoxic Conditions. [PDF]
Antibiotics (Basel)Feilcke R +4 more
europepmc +1 more source
F‐Type Pyocin Versus Phage λ Tail: Conserved Hub, Divergent Fibers
Advanced Science, EarlyView.Near‐atomic cryo‐EM structures of a Gram‐negative F‐type pyocin reveal a conserved tail tip architecture shared with bacteriophage λ together with a previously unrecognized side‐fiber attachment mode. These findings provide new insight into tailocin assembly and host recognition and establish a structural framework for engineering precision ...
Zhiwei Gu +5 more
wiley +1 more source
Chitosan nano-formulation enhances stability and bactericidal activity of the lytic phage HK6. [PDF]
BMC BiotechnolTemsaah HR +8 more
europepmc +1 more source
VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis
Advanced Science, EarlyView.Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang +7 more
wiley +1 more source
Quantification of bactericidal activity using the PATHFAST TB LAM Ag assay during the first 14 days of pulmonary tuberculosis treatment. [PDF]
Front AntibiotAkinaga A +6 more
europepmc +1 more source
Bio‐Based Polyurethanes for Sustainable and Multifunctional Applications
Advanced Science, EarlyView.Bio‐based polyurethanes prepared from vegetable oils, lignin, and polysaccharides have attracted increasing interest as alternatives to fossil‐derived polyurethanes. This review summarizes recent progress in their chemistry, structural engineering, and advanced applications, highlighting the roles of feedstocks, chain‐segment design, dynamic covalent ...
Xin Li +6 more
wiley +1 more source
Contezolid Harbored Equivalent Efficacy to Linezolid in Tuberculosis Treatment in a Prospective and Randomized Early Bactericidal Activity Study. [PDF]
Infect Drug ResistJiang G +14 more
europepmc +1 more source