Results 271 to 280 of about 131,877 (321)

Targeting Cancer With Bifunctional Peptides: Mechanism of Cell Entry and Inciting Cell Death

open access: yesCancer Science, EarlyView.
()‐D‐Tox peptide binding to the ligands triggers their internalization via clathrin‐mediated endocytosis. Intracellular presence of ()‐D‐Tox peptide induces a transient loss of mitochondrial membrane integrity and oligomerization of MLKL. Translocation of the oligomers to the plasma membrane causes a leakage of the cytosolic content and ultimately ...
Maria F. Setiawan   +2 more
wiley   +1 more source

Editorial: Global excellence in bacteriology: Central and South America. [PDF]

open access: yesFront Cell Infect Microbiol
Navarro-Garcia F, Brocchi M, Cataldi AA.
europepmc   +1 more source

Early Origins of Asthma and Allergies: Clues From Studies in China

open access: yesClinical &Experimental Allergy, EarlyView.
The environment we live in harbours both risk and protective factors for asthma and allergies. This is particularly relevant in China, where unique environmental and cultural factors shape disease development. The interplay between these environmental factors, airway immunity, and gut microbiome shapes the susceptibility to asthma and allergies ...
Yike Wang   +5 more
wiley   +1 more source

A Novel Bacteriophage with the Potential to Inhibit Fusobacterium nucleatum-Induced Proliferation of Colorectal Cancer Cells. [PDF]

open access: yesAntibiotics (Basel)
Lam HYP   +8 more
europepmc   +1 more source

Assessment of Patients With Beta‐Lactams Positive Provocation Tests by Biomarkers of IgG‐Related Neutrophil Activation

open access: yesClinical &Experimental Allergy, EarlyView.
Neutrophil activation in beta‐lactams (BL) immediate hypersensitivity reactions (IHR). Factor component analysis of IHR biomarkers suggests an IgG‐mediated mechanism. We propose Neutrophil Elastase as a biomarker of neutrophil activation in BL IHR. ABSTRACT Background Beta‐lactams (BLs) are the predominant cause of immediate allergic reactions to drugs.
Adrienne Astrid Gallizzi   +13 more
wiley   +1 more source

Simultaneous Discovery–Invention in Corporate R&D: Lessons from the CRISPR Case

open access: yesEuropean Management Review, EarlyView.
Abstract Some companies invest in fundamental research, but many struggle when developing novel in‐house scientific knowledge and integrating it into their new inventions. While the literature advocates revised approaches to better understand this phenomenon, we investigate the processes that lead to Simultaneous Discovery–Invention (SDI).
Quentin Plantec   +2 more
wiley   +1 more source

Membrane selectivity and pore formation of SprA1 and SprA2 hemolytic peptides from Staphylococcus aureus type I toxin–antitoxin systems

open access: yesThe FEBS Journal, EarlyView.
When overexpressed in Staphylococcus aureus, the type I toxins SprA1 and SprA2 form membrane pores, with SprA1 creating stable pores and SprA2 forming transient ones. Both induce concomitant membrane depolarization, ATP release, and growth arrest, while only SprA1 causes membrane permeabilization due to its stable pore formation.
Laurence Fermon   +10 more
wiley   +1 more source

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