Results 91 to 100 of about 158,920 (243)

Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice

Advanced Science, EarlyView.
CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Jie Zhu, Xi‐xiu Xie, Lei Li, Chen Tian, Hao‐tian Wang, Xiao‐jie Wang, Xiao‐lin Yu, Gui‐feng Zhang, Rui‐tian Liu   +8 more
wiley   +1 more source

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

Advanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang, Xinyuan Li, Lixia Huang, Xiangcai Zhang, Wujian Ke   +4 more
wiley   +1 more source

Bacteriophage T4 resistance to lysis-inhibition collapse

Genetical Research, 1999
Lysis inhibition is a mechanism of latent-period extension and burst-size increase that is induced by the T4 bacteriophage adsorption of T4-infected cells. Mutants of T4 genes imm, sp and 5 (specifically the ts1 mutant of 5) display some lysis inhibition. However, these mutants experience lysis-inhibition collapse, the lysis of lysis-inhibited cells,
openaire   +2 more sources

A Dual‐Delivery System Designed to Overcome EV‐Mediated Ferroptosis Resistance for Efficient Solid Tumor Therapy

Advanced Science, EarlyView.
(A) Establishment and characterization of the osteosarcoma‐targeted dual‐delivery nanoplatform mBAP1/siENO1@LNP‐OTP for simultaneous regulation of BAP1 and ENO1 in tumor cells. (B) After intravenous administration, mBAP1/siENO1@LNP‐OTP preferentially accumulates at tumor sites through OTP‐mediated targeting.
Yechao Shen, Zhenguo Cao, Zenan Wang, Liang Chen, Jiahao Zhang, Linjie Zeng, Boren Tan, Hengyuan Li, Jiashan Lai, Jiangchu Lei, Fanglu Chen, Peng Lin, Zhenxuan Shao, Zhan Wang   +13 more
wiley   +1 more source

Advancements in non – conventional therapeutics: A multi-targeted approach to

The Microbe
Klebsiella pneumoniae , one of the major multidrug-resistant opportunistic pathogens, poses a severe challenge in the field of healthcare, causing persistent, treatment-refractory infections owing to its intense biofilm-forming capacity.
Vanjinathan Mani, Nikita Gupta, Ethakoti Reddikavitha, Veronika Shalini, Mariselvam Thangavel, Sathiavelu Arunachalam   +5 more
doaj   +1 more source

Mycobacteriophage Lysis Enzymes: Targeting the Mycobacterial Cell Envelope

Viruses, 2018
Mycobacteriophages are viruses that specifically infect mycobacteria, which ultimately culminate in host cell death. Dedicated enzymes targeting the complex mycobacterial cell envelope arrangement have been identified in mycobacteriophage genomes, thus ...
Maria João Catalão, Madalena Pimentel
doaj   +1 more source

A simple and novel modification of comet assay for determination of bacteriophage mediated bacterial cell lysis

, 2014
The comet assay is the widely used method for in vitro toxicity testing which is also an alternative to the use of animal models for in vivo testing.
Paunikar, Waman, Chandekar, Rajshree, Khairnar, Krishna, Sanmukh, Swapnil   +3 more
core  

Delayed Lysis with a Mutant of Salmonella Bacteriophage P22 [PDF]

Journal of Virology, 1969
A mutant of bacteriophage P22 ( Lys − ) was isolated which shows a plaque morphology on mixed plates comparable to the r + plaques of the T-even phages. When Lys − and normal Lys + plaques are juxtaposed on a ...
openaire   +2 more sources

Recent Advances in Endolysin Engineering

Antibiotics
Antimicrobial resistance threatens a new “dark age” in medical practice. Chronic antibiotic overuse has driven the rise in antimicrobial resistance and promoted the emergence of multidrug-resistant organisms.
Mackenzie Aitken, Gayan Abeysekera, Craig Billington, Renwick C. J. Dobson   +3 more
doaj   +1 more source

Scalable Separation and Purification of M13‐Bacteriophage‐Derived Particles Containing Artificial Single‐Stranded DNA Produced by Escherichia coli

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Single‐stranded DNA (ssDNA) solutions are promising innovations shaping the future of genetic research and medical therapies. In principle, biotechnological mass production of ssDNA can be achieved using Escherichia coli in a high‐cell density fed‐batch process by secreting phagemid particles derived from the filamentous M13 bacteriophages ...
Nathalie Hafner, Wiebke Winkler, Maximilian N. Honemann, Hendrik Dietz, Dirk Weuster‐Botz   +4 more
wiley   +1 more source