Rapid bacteriolysis of Staphylococcus aureus by lysin exebacase [PDF]
Microbiology Spectrum, 2023 Lysins (peptidoglycan hydrolases) are promising new protein-based antimicrobial candidates under development to address rising antibiotic resistance encountered among pathogenic bacteria.
Steven Swift, Raymond Schuch
exaly +6 more sources
Intracellular bacteriolysis contributes to pathogenicity of Staphylococcus aureus by exacerbating AIM2-mediated inflammation and necroptosis [PDF]
Virulence, 2022 Staphylococcus aureus can survive within phagocytes. Indeed, we confirm in this study that approximately 10% of population persists in macrophages during S.
Jinfeng Miao, Yong Jun Yang
exaly +4 more sources
Engineering a T7 bacteriophage to attenuate LPS-driven inflammatory responses during bacteriolysis [PDF]
Applied and Environmental MicrobiologyBacterial lysis during treatment of Gram-negative infections can release lipopolysaccharide (LPS) and aggravate inflammation. Here, we engineered two complementary T7 bacteriophages: T7-nluc, a NanoLuc reporter bacteriophage for real-time monitoring of ...
Tong Yu +8 more
doaj +2 more sources
THE RELATION OF BACTERIOLYSIS TO PROTEOLYSIS [PDF]
Journal of Experimental Medicine, 1914 1. There is no demonstrable increase in non-coagulable nitrogen during bacteriolysis. 2. Bacteria treated with immune serum and complement are so altered that they are more readily digested by trypsin. 3. Bacteria treated with complement alone become more resistant to proteolysis. 4. Bacteria treated with an
Jobling James W, J W Jobling
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Listeria monocytogenes requires cellular respiration for NAD+ regeneration and pathogenesis [PDF]
eLife, 2022 Cellular respiration is essential for multiple bacterial pathogens and a validated antibiotic target. In addition to driving oxidative phosphorylation, bacterial respiration has a variety of ancillary functions that obscure its contribution to ...
Rafael Rivera-Lugo +12 more
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Bacteriolysis – a mere laboratory curiosity?
Critical Reviews in Microbiology, 2018 The role of bacteriolysis in the pathophysiology of microbial infections dates back to 1893 when Buchner and Pfeiffer reported for the first time the lysis of bacteria by immune serum and related this phenomenon to the immune response. Later on, basic anti-microbial peptides and certain beta-lactam antibiotics have been shown not only to kill ...
Issac Ginsburg, Erez Koren
exaly +3 more sources
A Novel Antimicrobial Metabolite Produced by Paenibacillus apiarius Isolated from Brackish Water of Lake Balkhash in Kazakhstan [PDF]
Microorganisms, 2022 Four aerobic bacteria with bacteriolytic capabilities were isolated from the brackish water site Strait Uzynaral of Lake Balkhash in Kazakhstan. The morphology and physiology of the bacterial isolates have subsequently been analyzed.
Alexander Meene +8 more
doaj +2 more sources
Synergistic Antibacterial Effect of Ethyl Acetate Fraction of Vernonia amygdalina Delile Leaves with Tetracycline against Clinical Isolate Methicillin-Resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa [PDF]
Advances in Pharmacological and Pharmaceutical Sciences, 2023 Multidrug-resistant bacteria have raised global concern about the inability to fight deadly infectious diseases. Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa are the most common resistant bacteria that are causing ...
Denny Satria +5 more
doaj +2 more sources
Enhancement of bacteriolysis of Shuffled phage PhiX174 gene E [PDF]
Virology Journal, 2011 Bacterial ghosts that are generated using the regulated PhiX174 lysis gene E offer a new avenue for the study of inactivated vaccines. Here, we constructed a library of mutant gene E using a gene-shuffling technique.
Wang Chun-lai +9 more
doaj +3 more sources
Structural insights into Cir-mediated killing by the antimicrobial protein Microcin V [PDF]
Communications BiologyDrug-resistant bacteria are a global concern. Novel treatments are needed, but are difficult to develop for Gram-negative species due to the need to traverse the outer membrane to reach targets beneath.
Stavros A. Maurakis +5 more
doaj +2 more sources