Results 1 to 10 of about 3,443 (171)

Rapid bacteriolysis of Staphylococcus aureus by lysin exebacase. [PDF]

Microbiology Spectrum, 2023
Lysins (peptidoglycan hydrolases) are promising new protein-based antimicrobial candidates under development to address rising antibiotic resistance encountered among pathogenic bacteria.
Steven Swift, Raymond Schuch
exaly   +6 more sources

Intracellular bacteriolysis contributes to pathogenicity of Staphylococcus aureus by exacerbating AIM2-mediated inflammation and necroptosis [PDF]

Virulence, 2022
Staphylococcus aureus can survive within phagocytes. Indeed, we confirm in this study that approximately 10% of population persists in macrophages during S.
Jinfeng Miao, Yongjun Yang
exaly   +4 more sources

Engineering a T7 bacteriophage to attenuate LPS-driven inflammatory responses during bacteriolysis [PDF]

Applied and Environmental Microbiology
Bacterial lysis during treatment of Gram-negative infections can release lipopolysaccharide (LPS) and aggravate inflammation. Here, we engineered two complementary T7 bacteriophages: T7-nluc, a NanoLuc reporter bacteriophage for real-time monitoring of ...
Tong Yu, Junjiao Pang, Mengge Chen, Qi Sun, Jiaqi Pu, Deshu Wang, Qingling Liu, Fengtang Yang, Hongkuan Deng   +8 more
doaj   +2 more sources

Bacteriolysis – a mere laboratory curiosity?

Critical Reviews in Microbiology, 2018
The role of bacteriolysis in the pathophysiology of microbial infections dates back to 1893 when Buchner and Pfeiffer reported for the first time the lysis of bacteria by immune serum and related this phenomenon to the immune response. Later on, basic anti-microbial peptides and certain beta-lactam antibiotics have been shown not only to kill ...
Issac Ginsburg, Erez Koren
exaly   +3 more sources

Enhancement of bacteriolysis of Shuffled phage PhiX174 gene E [PDF]

Virology Journal, 2011
Bacterial ghosts that are generated using the regulated PhiX174 lysis gene E offer a new avenue for the study of inactivated vaccines. Here, we constructed a library of mutant gene E using a gene-shuffling technique.
Wang Chun-lai, Zhao Hai-ling, Liu Hui-fang, Liu Si-guo, Yin Lu, Si Wei, Peng Wei, Yu Shen-ye, Chang Yue-hong, Lin Yue-zhi   +9 more
doaj   +3 more sources

Synergistic Antibacterial Effect of Ethyl Acetate Fraction of Vernonia amygdalina Delile Leaves with Tetracycline against Clinical Isolate Methicillin-Resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa [PDF]

Advances in Pharmacological and Pharmaceutical Sciences, 2023
Multidrug-resistant bacteria have raised global concern about the inability to fight deadly infectious diseases. Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa are the most common resistant bacteria that are causing ...
Denny Satria, Urip Harahap, Aminah Dalimunthe, Abdi Wira Septama, Triani Hertiani, Nasri Nasri   +5 more
doaj   +2 more sources

In Silico Design and Characterization of the Essential Outer-Membrane Lipoprotein LolB-Derived Multi-Epitope Vaccine Candidate Against Pseudomonas aeruginosa [PDF]

Methods and Protocols
Pseudomonas aeruginosa causes severe healthcare-associated infections, yet no vaccine has been licenced. To circumvent the antigenic variability of classical surface antigens, we evaluated LolB—an essential outer-membrane lipoprotein whose periplasmic ...
Sinethemba H. Yakobi, Uchechukwu U. Nwodo   +1 more
doaj   +2 more sources

Structural insights into Cir-mediated killing by the antimicrobial protein Microcin V [PDF]

Communications Biology
Drug-resistant bacteria are a global concern. Novel treatments are needed, but are difficult to develop for Gram-negative species due to the need to traverse the outer membrane to reach targets beneath.
Stavros A. Maurakis, Angela C. O’Donnell, Istvan Botos, Rodolfo Ghirlando, Bryan W. Davies, Susan K. Buchanan   +5 more
doaj   +2 more sources

The non-nutritive sweetener rebaudioside a enhances phage infectivity [PDF]

Scientific Reports
Non-nutritive sweeteners (NNS) are widely employed in foodstuffs. However, it has become increasingly evident that their consumption is associated with bacterial dysbiosis, which, in turn, is linked to several health conditions, including a higher risk ...
Luigi Marongiu, Ewa Brzozowska, Jan Brykała, Markus Burkard, Herbert Schmidt, Bożena Szermer-Olearnik, Sascha Venturelli   +6 more
doaj   +2 more sources

Phage cocktail amikacin combination as a potential therapy for bacteremia associated with carbapenemase producing colistin resistant Klebsiella pneumoniae [PDF]

Scientific Reports
The increasing occurrence of hospital-associated infections, particularly bacteremia, caused by extensively drug-resistant (XDR) carbapenemase-producing colistin-resistant Klebsiella pneumoniae highlights a critical requirement to discover new ...
Aye Mya Sithu Shein, Dhammika Leshan Wannigama, Cameron Hurst, Peter N. Monk, Mohan Amarasiri, Thidathip Wongsurawat, Piroon Jenjaroenpun, Phatthranit Phattharapornjaroen, William Graham Fox Ditcham, Puey Ounjai, Thammakorn Saethang, Naphat Chantaravisoot, Vishnu Nayak Badavath, Sirirat Luk-in, Sumanee Nilgate, Ubolrat Rirerm, Sukrit Srisakul, Naris Kueakulpattana, Matchima Laowansiri, S. M. Ali Hosseini Rad, Supaporn Wacharapluesadee, Apaporn Rodpan, Natharin Ngamwongsatit, Arsa Thammahong, Hitoshi Ishikawa, Robin James Storer, Asada Leelahavanichkul, Naveen Kumar Devanga Ragupathi, Annika Y. Classen, Talerngsak Kanjanabuch, Daniel Pletzer, Kazuhiko Miyanaga, Longzhu Cui, Hiroshi Hamamoto, Paul G. Higgins, Anthony Kicic, Tanittha Chatsuwan, Parichart Hongsing, Shuichi Abe   +38 more
doaj   +2 more sources