Structural mechanism of bacteriophage lambda tail’s interaction with the bacterial receptor [PDF]
Nature CommunicationsBacteriophage infection, a pivotal process in microbiology, initiates with the phage’s tail recognizing and binding to the bacterial cell surface, which then mediates the injection of viral DNA.
Xiaofei Ge, Jiawei Wang
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Revisiting bistability in the lysis/lysogeny circuit of bacteriophage lambda. [PDF]
PLoS ONE, 2014 The lysis/lysogeny switch of bacteriophage lambda serves as a paradigm for binary cell fate decision, long-term maintenance of cellular state and stimulus-triggered switching between states. In the literature, the system is often referred to as "bistable.
Michael Bednarz +3 more
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The protein interaction map of bacteriophage lambda [PDF]
BMC Microbiology, 2011 Background Bacteriophage lambda is a model phage for most other dsDNA phages and has been studied for over 60 years. Although it is probably the best-characterized phage there are still about 20 poorly understood open reading frames in its 48-kb genome ...
Uetz Peter +2 more
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Bacteriophage lambda: a paradigm revisited. [PDF]
J Virol, 2010 ABSTRACT Bacteriophage lambda has an archetypal immunity system, which prevents the superinfection of its Escherichia coli lysogens. It is now known that superinfection can occur with toxigenic lambda-like phages at a high frequency, and here we demonstrate that the superinfection of a lambda lysogen can ...
Fogg PC +3 more
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Cooperativity Leads to Temporally-Correlated Fluctuations in the Bacteriophage Lambda Genetic Switch [PDF]
Frontiers in Plant Science, 2015 Cooperative interactions are widespread in biochemical networks, providing the nonlinear response that underlies behavior such as ultrasensitivity and robust switching.
Jacob Quinn Shenker, Milo M Lin
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Bacteriophage lambda site-specific recombination. [PDF]
Mol MicrobiolAbstractThe site‐specific recombination pathway of bacteriophage λ encompasses isoenergetic but highly directional and tightly regulated integrative and excisive reactions that integrate and excise the vial chromosome into and out of the bacterial chromosome.
Van Duyne GD, Landy A.
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Single-molecule measurements of bacteriophage lambda DNA packaging using purified terminase motor proteins and E. coli integration host factor [PDF]
Scientific ReportsBiomotor-driven DNA packaging is a key step in the life cycle of many viruses. We previously developed single-molecule methods using optical tweezers to measure packaging dynamics of the bacteriophage lambda motor.
Brandon Rawson +3 more
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Purification of bacteriophage lambda repressor. [PDF]
Protein Expr Purif, 2013 Bacteriophage lambda repressor controls the lysogeny/lytic growth switch after infection of E. coli by lambda phage. In order to study in detail the looping of DNA mediated by the protein, tag-free repressor and a loss-of-cooperativity mutant were expressed in E.coli and purified by (1) ammonium sulfate fractionation, (2) anion-exchange chromatography ...
Gao N +4 more
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The Bacteriophage Lambda CII Phenotypes for Complementation, Cellular Toxicity and Replication Inhibition Are Suppressed in cII-oop Constructs Expressing the Small RNA OOP [PDF]
Viruses, 2018 The temperate bacteriophage lambda (λ) CII protein is a positive regulator of transcription from promoter pE, a component of the lysogenic response. The expression of cII was examined in vectors devoid of phage transcription-modulating elements.
Karthic Rajamanickam, Sidney Hayes
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Comparative genomics of Shiga toxin encoding bacteriophages [PDF]
BMC Genomics, 2012 Background Stx bacteriophages are responsible for driving the dissemination of Stx toxin genes (stx) across their bacterial host range. Lysogens carrying Stx phages can cause severe, life-threatening disease and Stx toxin is an integral virulence factor.
Smith Darren L +6 more
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