Structural mechanism of bacteriophage lambda tail’s interaction with the bacterial receptor [PDF]
Nature CommunicationsBacteriophage infection, a pivotal process in microbiology, initiates with the phage’s tail recognizing and binding to the bacterial cell surface, which then mediates the injection of viral DNA.
Xiaofei Ge, Jiawei Wang
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The protein interaction map of bacteriophage lambda [PDF]
BMC Microbiology, 2011 Background Bacteriophage lambda is a model phage for most other dsDNA phages and has been studied for over 60 years. Although it is probably the best-characterized phage there are still about 20 poorly understood open reading frames in its 48-kb genome ...
Uetz Peter +2 more
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Cooperativity Leads to Temporally-Correlated Fluctuations in the Bacteriophage Lambda Genetic Switch [PDF]
Frontiers in Plant Science, 2015 Cooperative interactions are widespread in biochemical networks, providing the nonlinear response that underlies behavior such as ultrasensitivity and robust switching.
Jacob Quinn Shenker, Milo M Lin
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Single-molecule measurements of bacteriophage lambda DNA packaging using purified terminase motor proteins and E. coli integration host factor [PDF]
Scientific ReportsBiomotor-driven DNA packaging is a key step in the life cycle of many viruses. We previously developed single-molecule methods using optical tweezers to measure packaging dynamics of the bacteriophage lambda motor.
Brandon Rawson +3 more
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Comparative genomics of Shiga toxin encoding bacteriophages [PDF]
BMC Genomics, 2012 Background Stx bacteriophages are responsible for driving the dissemination of Stx toxin genes (stx) across their bacterial host range. Lysogens carrying Stx phages can cause severe, life-threatening disease and Stx toxin is an integral virulence factor.
Smith Darren L +6 more
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The Bacteriophage Lambda CII Phenotypes for Complementation, Cellular Toxicity and Replication Inhibition Are Suppressed in cII-oop Constructs Expressing the Small RNA OOP [PDF]
Viruses, 2018 The temperate bacteriophage lambda (λ) CII protein is a positive regulator of transcription from promoter pE, a component of the lysogenic response. The expression of cII was examined in vectors devoid of phage transcription-modulating elements.
Karthic Rajamanickam, Sidney Hayes
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A CI-independent form of replicative inhibition: turn off of early replication of bacteriophage lambda. [PDF]
PLoS ONE, 2012 Several earlier studies have described an unusual exclusion phenotype exhibited by cells with plasmids carrying a portion of the replication region of phage lambda.
Sidney Hayes +2 more
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Water microdroplet platforms for sustainable, reagent-free viral disinfection [PDF]
Journal of Biological EngineeringBackground The repeated emergence of global pandemics has highlighted the urgent need for safe, sustainable, and effective disinfection platforms that eliminate viruses without producing toxic by-products or causing surface damage associated with ...
Juyoung Sheen +4 more
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Illuminating the Invisible: Green Fluorescent Protein as a Beacon for Antibiotic-Induced Phage Activity in Escherichia coli [PDF]
AntibioticsBackground/Objectives: Antibiotic resistance presents an urgent public health threat. By developing a streamlined and effective method for studying bacteriophage induction, this research marks a step further in understanding how antibiotic-resistant ...
Maria João Silva +3 more
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Single-phage profiling illuminates viral individuality during bacterial cell fate determination [PDF]
Nature CommunicationsThe choice between cell death (lysis) and viral dormancy (lysogeny) following bacteriophage infection serves as a founding paradigm for the emergence of cellular heterogeneity in a genetically uniform population.
Ehsan Homaee +3 more
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