Bacteriophage T4 Head: Structure, Assembly, and Genome Packaging [PDF]
Viruses, 2023 Bacteriophage (phage) T4 has served as an extraordinary model to elucidate biological structures and mechanisms. Recent discoveries on the T4 head (capsid) structure, portal vertex, and genome packaging add a significant body of new literature to phage ...
Venigalla B. Rao +3 more
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Survival of Bacteriophage T4 in Quasi-Pure Ionic Solutions [PDF]
Viruses, 2023 The preservative qualities of individual ionic compounds impacting the infectivity of T4 virions were elucidated. T4 virions were immersed in quasi-pure ionic solutions prior to the adsorption process, and the plaque forming unit (pfu) values of these ...
Seiko Hara, Isao Koike
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Recombinant bacteriophage T4 Rnl1 impacts Streptococcus mutans biofilm formation [PDF]
Journal of Oral Microbiology, 2021 Bacteriophage T4 RNA ligase 1 (T4 Rnl1) can be stably expressed in many bacteria and has been reported to affect the bioactivity of the host bacteria.
Juxiu Chen +4 more
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The Beauty of Bacteriophage T4 Research: Lindsay W. Black and the T4 Head Assembly [PDF]
Viruses, 2022 Viruses are biochemically complex structures and mainly consist of folded proteins that contain nucleic acids. Bacteriophage T4 is one of most prominent examples, having a tail structure that contracts during the infection process.
Andreas Kuhn, Julie A. Thomas
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Discrete long-range on-cell motion of bacteriophage T4 [PDF]
Microbiology SpectrumThe ability of a bacteriophage to distinguish between a suitable and a non-suitable bacterial host is critical for its survival. The series of events occurring between first contact and irreversible binding of a phage to its host is likely playing an ...
Lisa Laura Dreesens +3 more
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Bacteriophage T4 and its relatives [PDF]
Virology Journal, 2010 Bacteriophage T4 and its relatives (A series of critical reviews) Jim Karam & Eric Miller In the coming months Virology Journal will publish a number of authoritative reviews about the biochemistry, structural biology and genomics of the bacteriophage T4 and the T4-related phages.
Miller Eric S, Karam Jim D
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Bacteriophage T4 Vaccine Platform for Next-Generation Influenza Vaccine Development [PDF]
Frontiers in Immunology, 2021 Developing influenza vaccines that protect against a broad range of viruses is a global health priority. Several conserved viral proteins or domains have been identified as promising targets for such vaccine development.
Mengling Li +21 more
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Cryo-EM structures of bacteriophage T4 portal-neck assembly intermediates reveal a viral genome retention mechanism [PDF]
Nature CommunicationsBacteriophage T4 has long served as an extraordinary model for tailed phages. During virion assembly, the viral DNA genome is tightly packed into the head, to which tail attaches via a portal-neck connector.
Lin Han +12 more
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Genetic manipulation of bacteriophage T4 utilizing the CRISPR-Cas13b system [PDF]
Frontiers in Genome EditingCRISPR-Cas type II and type V systems are inefficient in modifying bacteriophage T4 genome, due to hypermodification of its DNA. Here, we present a genome editing technique for bacteriophage T4 using the type VI CRISPR-Cas system.
Yuvaraj Bhoobalan-Chitty +3 more
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Bacteriophage T4 Escapes CRISPR Attack by Minihomology Recombination and Repair [PDF]
mBio, 2021 Bacteriophages (phages) are viruses that infect bacteria and use them as replication factories to assemble progeny phages. Bacteria have evolved powerful defense mechanisms to destroy the invading phages by severing their genomes soon after entry into ...
Xiaorong Wu +3 more
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