Results 131 to 140 of about 44,922 (302)

Engineering magnetically guided bacteriophages for precision antimicrobial therapy and targeted biofilm eradication [PDF]

Yeping Ma, Sylvia Yang Liu, Minqi Hu, Wei Wei, Kun Ma, Bo Zhu, Sirui Li, Bee Luan Khoo, Song Lin Chua   +8 more
openalex   +1 more source

Washed Microbiota Transplantation Using Ileocolic Transendoscopic Enteral Tubing Versus Basic Treatments for Intestinal Inflammatory Obstruction in Crohn's Disease: A Multicenter Concurrent Controlled Trial

Microbiota Medicine Research, EarlyView.
Washed microbiota transplantation using ileocolic transendoscopic enteral tubing was identified as a viable, effective and safe bridge treatment for intestinal inflammatory obstruction in Crohn's disease, demonstrating significantly higher 28‐day improvement rates compared to basic treatment.
You Yu, Xinlu Jin, Zhaoyang Zhao, Weihong Wang, Fan Xu, Chengran Wang, Sibusiso Luthuli, Xiaoshuang Xu, Quan Wen, Bota Cui, Honggang Wang, Faming Zhang   +11 more
wiley   +1 more source

Bacteriophage Therapy Decreases Pseudomonas Aeruginosa Lung Inflammation [PDF]

, 2020
G.L. Stanley, Benjamin K. Chan, Isabel M. Ott, E. Mayo, Z.M. Harris, Ying Sun, Bo Hu, Govindarajan Rajagopalan, Paul E. Turner, Jonathan L. Koff   +9 more
openalex   +1 more source

Refining responsive antimicrobial nanomaterials from random peptide libraries via machine learning

Responsive Materials, EarlyView.
Machine learning refines random peptide mixtures into responsive antimicrobial cocktails, yielding enhanced antibacterial efficacy and improved in vivo therapeutic effects. Abstract Antimicrobial resistance has evolved into one of the most serious threats to global public health, yet generalizable routes for refining random peptide mixtures (RPMs) into
Lin Wang, Lexuan Shi, Bocheng Xu, Lutong Zhou, Tingjun Chen, Chen Yang, Mingliang Jin, Yizhen Wang   +7 more
wiley   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Medical Gas Plasma Inactivates Adenoviruses via Capsid Oxidation

Small, EarlyView.
Oxidative modification of three adenoviral capsid proteins after gas plasma treatment. Schematic representation of the viral infection process, starting with the initial attachment of the virus via its fiber protein binding to the cellular receptors (CAR and/or CD46). In the secondary attachment step, the penton base binds to integrin structures on the
Anke Schmidt, Meike Heuser, Paul Schulan, Lea Miebach, Alice Martinet, Marcus Frank, Kristian Wende, Sander Bekeschus   +7 more
wiley   +1 more source

Endemic bacteriophages: a cautionary tale for evaluation of bacteriophage therapy and other interventions for infection control in animals [PDF]

, 2012
Andrew M. Kropinski, Erika J. Lingohr, Dianne Moyles, Shivani Ojha, Amanda Mazzocco, Yi‐Min She, Susan Bach, Erica A. Rozema, Kim Stanford, Tim A. McAllister, Roger P. Johnson   +10 more
openalex   +1 more source

Cas12Fold Accurately Predicts Cas12 Nuclease Structures to Enable Structure‐based Genome‐editing Engineering

Small Structures, EarlyView.
Cas12Fold, a deep‐learning framework tailored to Cas12 nucleases, uses evolutionary signals and iterative structure‐based alignment to resolve conformational complexity. This method outperforms general models in predicting key domains and states, accurately modeling enzymes such as Casλ.
Feng Xu, Zilong Zhao, Chang Liu, Meixia Yu, Ke Li, Yilin Jing, Peiyang Li, Beibei Xin, Jian Chen, Lizhu E, Jinsheng Lai, Zhijia Yang, Hainan Zhao   +12 more
wiley   +1 more source

Silk Route to the Acceptance and Re-Implementation of Bacteriophage Therapy—Part II [PDF]

, 2018
Wilbert Sybesma, Christine H. Rohde, Pavol Bárdy, Jean‐Paul Pirnay, Ian Cooper, Jonathan Caplin, Ніна Чанішвілі, Aidan Coffey, Daniël De Vos, Amber Hartman Scholz, Shawna McCallin, Hilke Marie Püschner, Roman Pantůček, Rustam Aminov, Jiřı́ Doškař, D. İpek Kurtböke, D. Kurtbӧke   +16 more
openalex   +1 more source

Nanobody–chlorin e6 conjugate for Nectin‐4‐mediated tumor targeting and enhanced photodynamic therapy

VIEW, EarlyView.
Nectin‐4 is frequently overexpressed in solid tumors, yet many PDT photosensitizers show poor water solubility and nonspecific uptake. A Nectin‐4‐targeted nanobody–chlorin e6 conjugate (NPC) improves aqueous solubility and selectively accumulates in Nectin‐4‐positive tumor cells.
Haodian Wan, Tao Ye, Yawei Bi, Jiayu Zhang, Wei Wu, Aochi Liu, Li Sun, Jie Lin, Ningli Chai, Manjie Zhang, Jian Ma   +10 more
wiley   +1 more source