Results 141 to 150 of about 44,922 (302)

HK022 bacteriophage Integrase mediated RMCE as a potential tool for human gene therapy

, 2020
Amer Elias, Hala Kassis, Suha Abd Elkader, Natasha Gritsenko, Alessio D. Nahmad, Hodaya Shir, Liana Younis, Atheer Shannan, Hideki Aihara, Gali Prag, Ezra Yagil, Mikhail Kolot   +11 more
openalex   +1 more source

Inhibition of Targeted Bacterial Growth Using MazF‐Expressing Phagemids: A Novel Therapeutic Approach Based on Endoribonuclease Toxin Molecules

Microbiology and Immunology, EarlyView.
ABSTRACT The extensive and indiscriminate use of antibiotics, which are intended to halt bacterial growth or eliminate them, has unintentionally given rise to antimicrobial resistance (AMR), which is a critical threat to global health. In the pursuit of alternative solutions, researchers have focused on type II toxin–antitoxin systems prevalent within ...
Hana Hasegawa, Tatsuki Miyamoto, Rino Isshiki, Tomoyoshi Kaneko, Kenichi Takasugi, Naohiro Noda, Satoshi Tsuneda   +6 more
wiley   +1 more source

Bacteriophage Therapy Against Klebsiella Pneumoniae. [PDF]

Microorganisms
Ding W, Wen Y, Chen L, Du H.
europepmc   +1 more source

Bacteriophages targeting Enterococcus faecalis strains - a potential new root canal therapy [PDF]

, 2017
Mohammed Al Zubidi
openalex   +1 more source

The Role of Genomics in Advancing and Standardising Bacteriophage Therapy. [PDF]

Antibiotics (Basel)
Abdraimova N, Shitikov E, Kornienko M.
europepmc   +1 more source

More Than Microbiome and Medicine

Microbiota Medicine Research, EarlyView.
Faming Zhang, Sunny H. Wong, Yang‐Yu Liu   +2 more
wiley   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Phosphatase PPP1CC Regulates the First Lineage Segregation by GAS5 in Mouse Preimplantation Embryos

Cell Proliferation, EarlyView.
Subcortical GAS5 directs PPP1CC phosphatase spatiotemporal positioning during mouse morula‐blastocyst transition, controlling YAP dephosphorylation to drive first embryonic lineage specification. ABSTRACT The transcriptional effector of the Hippo signalling pathway, YAP, regulates the first lineage specification in mouse preimplantation embryos ...
Jianwu Wang, Yan Zhang, Laijin Wu, Hongshuang Xie, Guang Yang, Yiwei Zhang, Cheng Huang, Shanyi Chou, Xuehan Li, Zhonghua Liu, Jiaqiang Wang   +10 more
wiley   +1 more source

Editorial: Bacteriophage therapy in orthopedics-Key questions and emerging answers. [PDF]

J Orthop Traumatol
Migliorini F, Rivera F, Eschweiler J.
europepmc   +1 more source

Pharmacokinetics/pharmacodynamics of antipseudomonal bacteriophage therapy in rats: a proof-of-concept study [PDF]

, 2020
Yu Lin, Rachel Yoon Kyung Chang, Gauri G. Rao, Brian Jermain, Mei‐Ling Han, Jinxin Zhao, Kewei Chen, J.P. Wang, Jeremy J. Barr, Robert T. Schooley, Elizabeth Kutter, Hak‐Kim Chan, Jian Li   +12 more
openalex   +1 more source