Results 131 to 140 of about 11,802,102 (404)
Advanced Science, EarlyView.The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang +8 more
wiley +1 more source
The unknotted strands of life: knots are very rare in RNA structures [PDF]
arXiv, 2014 The ongoing effort to detect and characterize physical entanglement in biopolymers has so far established that knots are present in many globular proteins and also abound in viral DNA packaged inside bacteriophages. RNA molecules, on the other hand, have not yet been systematically screened for the occurrence of physical knots.
arxiv
Effects of Noise on Ecological Invasion Processes: Bacteriophage-mediated Competition in Bacteria [PDF]
, 2006 Pathogen-mediated competition, through which an invasive species carrying and transmitting a pathogen can be a superior competitor to a more vulnerable resident species, is one of the principle driving forces influencing biodiversity in nature.
arxiv +1 more source
Advanced Science, EarlyView.This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen +11 more
wiley +1 more source
Temperate and chronic virus competition leads to low lysogen frequency [PDF]
arXiv, 2019 The canonical bacteriophage is obligately lytic: the virus infects a bacterium and hijacks cell functions to produce large numbers of new viruses which burst from the cell. These viruses are well-studied, but there exist a wide range of coexisting virus lifestyles that are less understood.
arxiv
Ion-dependent dynamics of DNA ejections for bacteriophage lambda [PDF]
, 2010 We study the control parameters that govern the dynamics of in vitro DNA ejection in bacteriophage lambda. Past work has demonstrated that bacteriophage DNA is highly pressurized; this pressure has been hypothesized to help drive DNA ejection.
arxiv +1 more source
Isolation and selection of a bacteriophage-typing set for Enterobacter cloacae.
Journal of Medical Microbiology, 1987 Seventy-six phages active against Enterobacter cloacae were isolated from sewage and other sources. They were tested at RTD on 92 selected strains of E. cloacae and their lytic reactions were used to select phages for a typing set.
M. A. Gaston
semanticscholar +1 more source
Bacteriophage Typing as an Epidemiological Tool for Urinary Escherichia coli [PDF]
, 1969 Joseph T. Parisi +2 more
openalex +2 more sources
Structure and Antigenicity of Kaposi's Sarcoma‐Associated Herpesvirus Glycoprotein B
Advanced Science, EarlyView.Kaposi's sarcoma‐associated herpesvirus (KSHV) causes severe cancers without effective treatments. This study presents an atomic model of KSHV's critical infection protein, gB, revealing a unique structure shared with related herpesviruses like Epstein‐Barr virus (EBV). The structural similarity highlights vulnerable targets for antibodies, guiding the
Xin‐Yan Fang +8 more
wiley +1 more source
A stochastic model for bacteriophage therapies [PDF]
Math. Biosci. (2013) 99-108, 2011 In this article, we analyze a system modeling bacteriophage treatments for infections in a noisy context. In the small noise regime, we show that after a reasonable amount of time the system is close to a sane equilibrium (which is a relevant biologic information) with high probability.
arxiv