Results 141 to 150 of about 25,843 (353)
Multi‐Targeting Non‐Specific Genome Engineering in Bacteria
Advanced Science, EarlyView.In this study, we provide the first case to use the multi‐targeting integrase (MTI) systems in bacteria and develop a host‐independent generalizable approach, MNGE (Multi‐targeting Non‐specific Genome Engineering), for multi‐copy and random integration of metabolic genes or pathways in both Gram‐positive and Gram‐negative bacteria, which will ...
Runze Sun +7 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals circRSU1 with important oncogenic roles in hepatocellular carcinoma (HCC). CircRSU1, highly abundant in HCC, interacts with and stabilizes hnRNPA1 from ubiquitination and degradation. This stabilization facilitates hnRNPA1 binding to the internal ribosome entry site of HIF1A to increase HIF‐1α protein translation.
Shuting Xue +14 more
wiley +1 more source
Advanced Science, EarlyView.The RNA G‐quadruplexes formed at the 5'‐end of the RNA component of human telomerase possess extreme slow unfolding rate, rendering them resistant to nuclease degradation. The helicase DHX36 overcame this kinetic barrier and significantly reduced the folded fraction.
Qun Luo +5 more
wiley +1 more source
Sizes and concentrations of several type C oncornaviruses and bacteriophage T2 by the resistive-pulse technique [PDF]
, 1977 R. W. DeBlois, Roy K.A Wesley
openalex +1 more source
Advanced Science, EarlyView.Urinary Fusobacterium nucleatum–derived outer membrane vesicles are shown to promote bladder cancer lymphatic metastasis. The vesicle protein FomA activates TLR2/NF‐κB signaling in tumor cells, induces IL‐6 secretion, and drives M2b macrophage polarization and VEGF‐C–dependent lymphangiogenesis, revealing a microbiota‐driven mechanism linking tumor ...
Wentai Shangguan +17 more
wiley +1 more source
Brazilian Journal of Infectious Diseases, 2001 The objective of this study was to characterize patterns of the Brazilian endemic clone of methicillin-resistant Staphylococcus aureus (MRSA) from hospitals throughout Brazil.
Oliveira Geraldo A. +3 more
doaj
Cholera Bacteriophages: History of Discovery, Structure and Application
Проблемы особо опасных инфекцийViruses that affect cholera vibrio, or cholera bacteriophages, were discovered in early twentieth century, when the sixth cholera pandemic was raging in Southeast Asia, the Far and Middle East and Europe.
N. B. Cheldyshova +4 more
doaj +1 more source
Advanced Science, EarlyView.This review elucidates URB design strategies, including genetic and physicochemical modifications, while dissecting the synergistic mechanisms governing spatiotemporal control. It further evaluates applications in targeted drug delivery, gene modulation, and immunotherapy, finally offering perspectives on overcoming translational barriers for clinical ...
Xueyao Wang +5 more
wiley +1 more source
Angewandte Chemie, EarlyView.This study explores the origins of life by linking prebiotic chemistry, the emergence of information‐carrying molecules such as RNA and proteins, and philosophical questions about consciousness. The study emphasizes the role of molecular evolution in the Central Dogma and provides insights into the chemical origins of biology and the basis of life's ...
Harald Schwalbe +5 more
wiley +2 more sources
Efficient engineering of a bacteriophage genome using the type I-E CRISPR-Cas system [PDF]
, 2014 Ruth Kiro, Dror Shitrit, Udi Qimron
openalex +1 more source