Results 171 to 180 of about 17,041 (213)

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Isolation and characterization of a novel <i>Staphylococcus</i> phage SPD: genomic insights and its anti-biofilm efficacy against methicillin-resistant <i>Staphylococcus aureus</i>. [PDF]

Front Cell Infect Microbiol
Zheng X, Ma L, Li Y, Liu B, Zhang W, Su X, Liu Y.   +6 more
europepmc   +1 more source

Advances in Spatial Heterogeneity and Cellular Localization Specificity of Intratumoral Bacteria

Cancer Science, EarlyView.
Spatial localization of intratumoral bacteria governs their functional roles in tumor progression, metastasis, and treatment responses, with guiding significance for clinical management, as reviewed across three spatial paradigms. ABSTRACT Bacteria in tumors are increasingly recognized to be a part of the tumor microenvironment and their biological ...
Minlan Ren, Jing Jia, Tingting Li, Yiwei Li, Nanxiang Shen, Yun Shi, Zhe Wang, Hao Fan, Guangli Sun, Guanying Xiong, Gang Li, Rui Peng   +11 more
wiley   +1 more source

Characterization of resistance to last-line therapeutic molecules and genetic diversity of <i>Klebsiella</i> spp. strains involved in urinary tract infections in women: the case of Hôpital d'Instruction des Armées Omar Bongo Ondimba. [PDF]

J Med Microbiol
Mayombo Ngoussou E, Dikoumba AC, Mambu M, Mabika Mabika R, Zong Minko O, Mounioko F, Ondjiangui LF, Moyen R, Yala JF.   +8 more
europepmc   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Emergence and Dissemination of NDM+OXA-48-like Co-Producing <i>Klebsiella pneumoniae</i> in a Regional Healthcare Network: Seven-Year Surveillance from Latium, Italy. [PDF]

Antibiotics (Basel)
Venditti C, Rotondo C, Maestripieri C, Caparrelli C, Butera O, Properzi M, Nisii C, D'Arezzo S, Selleri M, Cervoni M, Tonziello G, Scognamiglio P, Siddu A, Fontana C.   +13 more
europepmc   +1 more source

A guide to the ecological limitations of phage therapy of bacterial biofilms: Is what's best for the phage best for the physician?

The FEBS Journal, EarlyView.
Bacteriophages—viruses that kill bacteria—are promising weapons against bacterial biofilms: sessile communities notoriously resistant to antibiotics. Yet phages evolved not so much to eradicate bacteria as to obtain new bacteria to infect. That goal, however, may conflict with the physician's objective of complete bacterial clearance.
Stephen T. Abedon
wiley   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

Genomic Analysis of Hypervirulent <i>Klebsiella pneumoniae</i> ST1-KL122. [PDF]

Iran J Biotechnol
Yang Y, He Z, Dai Y, Lu H, Li Y, Zhang Y, Sun B, Zhou S.   +7 more
europepmc   +1 more source