Alimentary Pharmacology &Therapeutics, EarlyView.In a cohort of IBS‐D patients recruited to the TRITON study, faecal metabolomic profiling reveals a SCFA‐enriched metabotype associated with increased pain and urgency, altered stool characteristics and accelerated intestinal transit. ABSTRACT Background Metabolomic analysis in irritable bowel syndrome (IBS) has identified metabotypes enriched in ...
T. E. Conley +8 more
wiley +1 more source
Distribution of microbial carrageenan foraging pathways reveals a widespread latent trait within the ruminant intestinal microbiome. [PDF]
Nat CommunTingley JP +17 more
europepmc +1 more source
Australian Veterinary Journal, Volume 104, Issue 6, Page 365-375, June 2026.Macropod progressive periodontal disease (MPPD) is a severe oral condition frequently observed in captive macropods, particularly red kangaroos (Osphranter rufus), yet its underlying biological features remain poorly understood. In this exploratory descriptive study, we investigated oral and fecal microbiomes and metabolomic profiles in captive red ...
Y Yoshimoto +4 more
wiley +1 more source
Gut microbiota may influence Sjögren's syndrome risk through immune cell mediation: A Mendelian randomization analysis. [PDF]
Medicine (Baltimore)Yang J +4 more
europepmc +1 more source
Prevalence of Anaerobic Bacteria in Surgical Site Infections in a Tertiary Care Hospital. [PDF]
CureusKedia R +6 more
europepmc +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
The Role of Gut Microbiota and Their Derived Metabolites in Chemotherapy-Induced Nausea and Vomiting in Ovarian Cancer. [PDF]
Cancer MedZu S, Yu X, Song J, Xiao Y, Yi H, Li H.
europepmc +1 more source
Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges
British Journal of Pharmacology, EarlyView.This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu +6 more
wiley +1 more source
Coevolution of Human Diet and Gut Microbiome: Implications for Nutrigenomics and Cross-Population Health. [PDF]
Int J MicrobiolSandra F +6 more
europepmc +1 more source
Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer
Cancer Science, EarlyView.Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo +6 more
wiley +1 more source