Results 81 to 90 of about 18,272 (219)

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Chromatin Remodeller BRD9 Orchestrates Odontoblastic Differentiation via Coordinating RUNX2‐KLF4

Cell Proliferation, EarlyView.
During odontoblast lineage commitment, the chromatin remodeller BRD9 acts as a critical epigenetic coordinator, orchestrating the chromatin landscape to facilitate synergistic binding of key transcription factors RUNX2 and KLF4 to target loci for odontogenesis.
Wenrui Zeng, Yuxiu Lin, Yongyan Gao, Delan Huang, Yuanyuan Li, Honglei Ruan, Guohua Yuan, Huan Liu, Zhi Chen   +8 more
wiley   +1 more source

Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle

The FEBS Journal, EarlyView.
EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini, Konstantinos Poalas, Margaux Versapuech, Clarisse Berlioz‐Torrent, Katy Janvier   +4 more
wiley   +1 more source

Perspectives and Experiences of Dentists on the Provision of Oral Healthcare to Frail Older Adults in General Dental Practices

Gerodontology, EarlyView.
ABSTRACT Background Population ageing has increased the number of frail older adults living independently and retaining their natural dentition. To support oral healthcare professionals in caring for this patient group, the Royal Dutch Dental Association published the practice guideline Care for Frail Older Adults in the Dental Practice.
Ellen Dekkers, Brigitte Amelia Francisca Maria van Dam, Joost Cornelis Lambertus den Boer, Dagmar Else Slot, Jan Josef Mathieu Bruers   +4 more
wiley   +1 more source

Morpho-agronomic traits of common bean landraces in two growing seasons
Características morfo-agronômicas de cultivares crioulas de feijão comum em dois anos de cultivo

Semina: Ciências Agrárias, 2010
The objective of this work was to characterize the genetic diversity of landrace beans in two years for morphologic and agronomy characteristics. Twenty four bean (Phaseolus vulgaris L.) genotypes were evaluated during the growing seasons of 2006/2007 ...
Cileide Maria Medeiros Coelho, Marcio Zilio, Clovis Arruda Souza, Altamir Frederico Guidolin, David José Miquelluti   +4 more
doaj  

General Dental Practitioners' and Dental Hygienists' Perspectives on the Dutch Guideline for Periodontal Screening, Diagnostics, and Treatment in General Practice

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Objectives In January 2021, the guideline ‘Periodontal Screening, Diagnosis, and Treatment in General Practice’ was introduced as a successor to the ‘Perio Protocol’. Simultaneously, the screenings tool ‘Dutch Periodontal Screening Index’ (DPSI) was replaced by the ‘Periodic Periodontal Screening’ (PPS).
J. C. L. den Boer, B. A. F. M. van Dam, G. A. van der Weijden, J. J. M. Bruers   +3 more
wiley   +1 more source

Exploring the Association Between Complaints of Sensory Hypersensitivity and Sleep Disturbances After Acquired Brain Injury: A Cross‐Sectional Study

Journal of Sleep Research, EarlyView.
ABSTRACT Sleep disturbances are prevalent after acquired brain injury and negatively affect quality of life. Sensory hypersensitivity may cause or exacerbate sleep disturbances, yet evidence on this relationship after acquired brain injury is lacking. The aim of this study was to investigate the hypothesised positive relationship between the severity ...
A. F. Ten Brink, W. I. J. van der Veere, J. A. de Graaf, I. Huenges Wajer, O. Verschuren   +4 more
wiley   +1 more source

Interactional Endocytosis and Transmembrane Transport Promote Cellular Internalization of Nano‐Delivered RNA Drugs for Efficient Control of Crop Diseases

Plant Biotechnology Journal, EarlyView.
ABSTRACT Botrytis cinerea is a widespread plant pathogenic ascomycete that causes grey mould in over 1400 species and impacts global crop yields. Double‐stranded RNA (dsRNA)‐induced gene silencing is a promising technology for pest control, but efficient delivery remains a major challenge.
Mei Guan, Chao Xie, Yang Xue, Juan Lu, Qinhong Jiang, Meizhen Yin, Shuo Yan, Jie Shen   +7 more
wiley   +1 more source

溶解氧/四环素对炭基BAF处理模拟养殖废水的影响

Gongye shui chuli
针对南疆养猪废水处理成本高及抗生素残留等问题，采用曝气生物滤池（BAF）处理模拟养殖废水，考察不同滤料对污染物去除效果的影响。设置3组反应器，分别为竹炭（Z-BAF）、陶粒（T-BAF）及竹炭+陶粒混合（ZT-BAF，体积比1∶1）反应器，通过调控溶解氧（DO）和四环素（TC）浓度，评估BAF对污染物的去除效能。结果表明，DO调节前（3.00~4.00 mg/L），各BAF对污染物降解性能稳定；调低DO后（1.50~2.50 mg/L），ZT-BAF较Z-BAF和T-BAF对COD和NH4 ...
王杰, 钟鸣扬, 李发永, 尤永军, 张娟香, 肖飞, 孙晓雷   +6 more
doaj  

Evaluation of the effect of local Bovine Amniotic Fluid on Osseointegration of Titanium Implants: A Histologic and Histomorphometric Study

Revista Científica
The aim of this study was to histologically and histomorphometrically investigate the effect of locally applied bovine amniotic fluid (BAF) on osseointegration levels in implants. Adult female Sprague–Dawley rats weighing 300–350 g were used as subjects.
Ozmen Istek, Murat Tanrisever, Melek Atille Aydin, Pınar Pak, Hatice Eroksuz, Burak Karabulut, Elif Ekinci, Serkan Dundar   +7 more
doaj   +1 more source