Results 61 to 70 of about 18,272 (219)

BAF goes nuclear

The Journal of Cell Biology, 2002
![][1] BAF bridges DNA (binding at either end) and nuclear envelope proteins (binding in the middle). Barrier-to-autointegration factor (BAF) was first described as a cellular activity that prevents retroviral DNA from undergoing suicidal autointegration, but its function ...
openaire   +2 more sources

滤料粒径对生物活性滤池除污染效能的影响

Gongye shui chuli, 2007
采用两种活性炭粒径的生物活性滤池(BAF):BAF-1的滤料粒径为0.8-1.2 mm, BAF-2为1.0-2.0 mm, 探讨了滤料粒径对BAF除污染能力的影响及作用机理。结果表明, 滤料粒径对BAF除有机污染物和氨氮的能力影响较大。两组BAF除浊性能差异不大。另外, 两组BAF均能显著降低滤前水的细菌总数, 同时, BAF-1的水头损失增长速度并不高于BAF-2。采用较小粒径的BAF-1具有更高的吸附容量, 并能为微生物的生长提供更大的表面积, 因而具有更优越的饮用水除污染效能。
田家宇, 陈伟雄, 王威, 李圭白
doaj  

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

A human progeria-associated BAF-1 mutation modulates gene expression and accelerates aging in C. elegans

The EMBO Journal
Alterations in the nuclear envelope are linked to a variety of rare diseases termed laminopathies. A single amino acid substitution at position 12 (A12T) of the human nuclear envelope protein BAF (Barrier to Autointegration Factor) causes Néstor ...
Raquel Romero-Bueno, Adrián Fragoso-Luna, Cristina Ayuso, Nina Mellmann, Alan Kavsek, Christian G Riedel, Jordan D Ward, Peter Askjaer   +7 more
doaj   +1 more source

A Single‐Amino‐Acid Ligand for LAT1: A Minimalist and Modular Platform for Lysosome‐Targeted Degradation of Membrane Proteins

Advanced Science, EarlyView.
LA‐LYTAC repurposes the cancer‐enriched amino acid transporter LAT1 as a lysosomal trafficking receptor for targeted membrane‐protein degradation. A single phenylalanine‐derived ligand, modularly linked to antibodies or small‐molecule binders, recruits PD‐L1, EGFR, or integrins to LAT1, triggering transporter‐mediated internalization, lysosomal ...
Liquan Zhu, Ke Liu, Haotian Liu, Chaoqi He, Xiaozhen Liu, Xin Zeng, Misha Mao, Yuxiao Mu, Ying Li, Qinghui Zheng, Hongchao Tang, Da Qian, Xuli Meng   +12 more
wiley   +1 more source

Targeting Tex10 Overcomes Oxaliplatin Resistance by Competitively Disrupting the Non‐Canonical BAF Complex in Colorectal Cancer

Advanced Science, EarlyView.
This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu, Jie Huang, Xiaojin Gao, Lin Deng, Yanheng Deng, Denglu Wang, Chunlei Yu, Yunxiang Zhang, Jingdong Li, Xiaocong Xiang   +9 more
wiley   +1 more source

Neighborhood Disadvantage and Comorbid Mental Health Conditions in Adolescents and Young Adults With Eating Disorders

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anxiety and depression are highly prevalent among adolescents and young adults with eating disorders. A comorbid mental health condition is associated with worsened long‐term eating disorder outcomes. While individual risk factors for comorbid anxiety or depression and eating disorders have been elucidated, the impact of external ...
Anita V. Chaphekar, Qing Duan, Janet Zahner, Andrew F. Beck   +3 more
wiley   +1 more source

Paroxysmal slow waves mark ictal networks

Epilepsia, EarlyView.
Abstract Objective Epilepsy diagnosis and treatment monitoring are hindered by the episodic, heterogeneous expression of seizures and by normal‐appearing scalp electroencephalography (EEG) in many patients. We previously described paroxysmal slow‐wave events (PSWEs), brief epochs of broadband slowing detectable on EEG in people with epilepsy.
Florent J. M. Boyer‐Aymé, Hamza Imtiaz, Ofer Prager, Evyatar Swissa, Alaa Abu Ahmad, Yonatan Serlin, Refat Aboghazleh, Ilan Goldberg, Maayan Ben nun Caller, Idit Tamir, Oded Shor, Ben Whatley, Felix Benninger, Alon Friedman   +13 more
wiley   +1 more source

Ecotoxicological Assessment of Mercury in Fish From a Gold‐Mining‐Impacted Amazonian River: Biomonitoring and Human Health Risk

Environmental Toxicology, EarlyView.
ABSTRACT The Peixoto de Azevedo River, located in northern Mato Grosso, southern Brazilian Amazon, has a long history of artisanal and small‐scale gold mining (ASGM). This study evaluated total mercury (THg) concentrations in fish tissues to assess biomagnification and potential risks.
Augusto Cesar da Costa Castilho, Kleber Solera, Vinícius José Santos Lopes, Gleyce Alves Machado, Ricardo Lopes Tortorela de Andrade, Leandro Dênis Battirola   +5 more
wiley   +1 more source

Crystal Structure and Eu2+ Luminescence of the Lithium Alkaline‐Earth Silicate Fluoride LiBa2SiO4F

Zeitschrift für anorganische und allgemeine Chemie, EarlyView.
With Li2BaSiO4F, a new lithium alkaline‐earth silicate fluoride could be synthesized via high‐temperature solid‐state reaction. Crystal structure and luminescence properties upon Eu2+ activation were investigated. A high‐temperature solid‐state synthesis in weld‐shut tantalum ampoules yielded a new alkaline‐earth silicate fluoride, LiBa2SiO4F.
Kilian M. Rießbeck, Hannah Holzer, Markus Seibald, Christiane Stoll, Frauke Philipp, Hubert Huppertz   +5 more
wiley   +1 more source