Results 51 to 60 of about 63,521 (249)

A New Approach to Quantifying Bioaccumulation of Elements in Biological Processes

Biology, 2021
Bioaccumulation, expressed as the bioaccumulation factor (BAF), is a phenomenon widely investigated in the natural environment and at laboratory scale.
Kinga Proc, Piotr Bulak, Monika Kaczor, Andrzej Bieganowski   +3 more
doaj   +1 more source

WISE Circumstellar Disks in the Young Sco-Cen Association

, 2011
We present an analysis of the WISE photometric data for 829 stars in the Sco-Cen OB2 association, using the latest high-mass membership probabilities. We detect infrared excesses associated with 135 BAF-type stars, 99 of which are secure Sco-Cen members.
A. C. Rizzuto, Artymowicz, Carpenter, Carpenter, Chen, Chen, Cox, Currie, D. B. Zucker, de Zeeuw, Gáspár, Kenyon, Kouwenhoven, Kraus, Lada, M. J. Ireland, Mamajek, Rieke, Rizzuto, Robichon, Silverstone, Strom, Su, van Leeuwen, Wright   +24 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta. [PDF]

, 2013
Amyloid protein aggregates are associated with dozens of devastating diseases including Alzheimer's, Parkinson's, ALS, and diabetes type 2. While structure-based discovery of compounds has been effective in combating numerous infectious and metabolic ...
Eisenberg, David S, Hughes, Michael P, Jiang, Lin, Landau, Meytal, Leibly, David, Liu, Cong, Zhao, Minglei   +6 more
core   +1 more source

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

When Conciliation Frustrates the Epistemic Priorities of Groups [PDF]

, 2021
Our aim in this chapter is to draw attention to what we see as a disturbing feature of conciliationist views of disagreement. Roughly put, the trouble is that conciliatory responses to in-group disagreement can lead to the frustration of a group's ...
Skipper, Mattias, Steglich-Petersen, Asbjørn   +1 more
core  

Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear‐induced Death During Hematogenous Dissemination

Advanced Science, EarlyView.
This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang, Qianchun Wang, Keming Li, Guanshuo Hu, Ying Xin, Kai Tang, Bing Hu, Pengyu Du, Renwei Mao, Baohua Ji, Youhua Tan   +10 more
wiley   +1 more source

YY1 Positively Regulates Transcription by Targeting Promoters and Super-Enhancers through the BAF Complex in Embryonic Stem Cells

Stem Cell Reports, 2018
Summary: Yin Yang 1 (YY1) regulates early embryogenesis and adult tissue formation. However, the role of YY1 in stem cell regulation remains unclear. YY1 has a Polycomb group (PcG) protein-dependent role in mammalian cells.
Jia Wang, Xingui Wu, Chao Wei, Xin Huang, Qian Ma, Xiaona Huang, Francesco Faiola, Diana Guallar, Miguel Fidalgo, Tingyuan Huang, Di Peng, Li Chen, Haopeng Yu, Xingyu Li, Junyi Sun, Xinyi Liu, Xiaoxia Cai, Xiao Chen, Ling Wang, Jian Ren, Jianlong Wang, Junjun Ding   +21 more
doaj   +1 more source

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis

Advanced Science, EarlyView.
Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang, Linlin Xu, Chenglong Pan, Ruonan Cao, Piao Zeng, Xinxing Lyu, Qingxia Hu, Zhenzhen Yan, Shuhong Huang, Ningning Dang   +9 more
wiley   +1 more source

The impact of dissolved oxygen/tetracycline on the treatment of simulated aquaculture wastewater by carbon-based BAF

Gongye shui chuli
To address the problems of high cost of swine wastewater treatment and antibiotic residues in South Xinjiang, the biological aerated filter(BAF) was used to treat the simulated aquaculture wastewater to investigate the effects of different filter media ...
WANG Jie, ZHONG Mingyang, LI Fayong, YOU Yongjun, ZHANG Juanxiang, XIAO Fei, SUN Xiaolei   +6 more
doaj   +1 more source