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Targeting the BAF complex in advanced prostate cancer
Expert Opinion on Drug Discovery, 2020The BRG1/BRM associated factors (BAF) complex is a chromatin remodeling SWI/SNF which is mutated in 20% of cancers. This complex has many interchangeable subunits which may have oncogenic or tumor suppressor activity in a context-dependent manner. The BAF complex is mutated in 35-50% of metastatic prostate cancer (PC); however, its role in advanced ...
Andrew, Hartley +2 more
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The BAF chromatin remodeling complexes: structure, function, and synthetic lethalities
Biochemical Society Transactions, 2021BAF complexes are multi-subunit chromatin remodelers, which have a fundamental role in genomic regulation. Large-scale sequencing efforts have revealed frequent BAF complex mutations in many human diseases, particularly in cancer and neurological disorders.
Julia Varga +3 more
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Vitamin D Switches BAF Complexes to Protect β Cells [PDF]
Cell, 2018 A primary cause of disease progression in type 2 diabetes (T2D) is β cell dysfunction due to inflammatory stress and insulin resistance. However, preventing β cell exhaustion under diabetic conditions is a major therapeutic challenge. Here, we identify the vitamin D receptor (VDR) as a key modulator of inflammation and β cell survival.
Zong Wei, Eiji Yoshihara, Nasun Hah
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Roles of chromatin remodeling BAF complex in neural differentiation and reprogramming
Cell and Tissue Research, 2014ATP-dependent BAF chromatin remodeling complexes play an essential role in the maintenance of the gene expression program by regulating the structure of chromatin. There is increasing evidence that BAF complexes based on the alternative ATPase subunits, Brg1 and Brm, control the differentiation of neural stem cells (NSCs) to generate distinct neural ...
Tran Cong Tuoc
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Numerous BAF complex genes are mutated in Coffin–Siris syndrome
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 2014Coffin–Siris syndrome (CSS; OMIM#135900) is a rare congenital anomaly syndrome characterized by intellectual disability, coarse face, hypertrichosis, and absence/hypoplasia of the fifth digits' nails. As the majority of patients are sporadic, an autosomal dominant inheritance model has been postulated.
Noriko, Miyake +2 more
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Continuous BAF Complex Function Is Required to Maintain Chromatin State
Cancer Discovery, 2021Abstract Disrupting the chromatin-remodeling BAF (SWI/SNF) complex's function altered chromatin in minutes.
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THE INTERACTION BETWEEN THE BAF AND INTEGRATOR COMPLEXES
ABSTRACTLindsey Hernandez: The Interaction Between the BAF and Integrator Complexes(Under the direction of Jesse Raab) The Integrator complex processes nascent RNAs and orchestrates RNA polymerase II pause/release; however, its interaction with the epigenome is unknown.openaire +1 more source
ERG Retargets BAF Complexes to Promote Prostate Oncogenesis
Cancer Discovery, 2018Abstract In TMPRSS2–ERG-positive prostate cancer, ERG retargets BAF chromatin remodeling complexes to ETS motifs.
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Targeting the BAF complex in advanced prostate cancer
Expert Opinion on Drug Discovery, 2021Hing Y Leung, Imran Ahmad
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