Neuronal activity-induced BRG1 phosphorylation regulates enhancer activation
Cell Reports, 2021 Summary: Neuronal activity-induced enhancers drive gene activation. We demonstrate that BRG1, the core subunit of SWI/SNF-like BAF ATP-dependent chromatin remodeling complexes, regulates neuronal activity-induced enhancers.
Yi Luo, Xiaoming Zhan, Jiaqing Yi
exaly +3 more sources
BRG1 orchestrates diabetic corneal neuropathy via PI3K/AKT-mediated glycolytic reprogramming [PDF]
Eye and VisionBackground Mounting evidence indicates metabolic dysregulation in diabetic corneal neuropathy (DCN). This study elucidates how the chromatin remodeler Brahma-related gene 1 (BRG1) orchestrates glycolytic reprogramming to drive neurodegeneration and ...
Yuyang Deng +3 more
doaj +2 more sources
Usefulness of BRG1 immunostaining in detecting SMARCA4 deficiency in “so-called” cancers of unknown primary in daily pathology practice [PDF]
Diagnostic PathologyBackground SMARCA4 encodes BRG1, loss of which is associated with aggressive tumor biology. Although SMARCA4 deficiency has been described in various malignancies, its role in “so-called” cancers of unknown primary (“so-called” CUP), that is, metastatic ...
Chie Hasegawa +7 more
doaj +2 more sources
Analysis of SWI Complex Subunits in 69 Cases of TTF-1 Negative Non-Small Cell Lung Carcinoma. [PDF]
Diagn CytopatholABSTRACT Non‐small cell lung carcinomas, not otherwise specified (NSCLC‐NOS) with a specific signature including high‐grade hepatoid/clear cell morphology, negative lung panel mutational analysis, negative TTF‐1/Napsin A staining can be reported as a morphologic variant of an aggressive carcinoma with loss of one of the subunits of the SWI/SNF ...
Zargham R, Ji FS, Bismar T.
europepmc +2 more sources
Frontiers in Cell and Developmental Biology, 2020 Liver fibrosis is a complex pathophysiological process to which many different cell types contribute. Endothelial cells play versatile roles in the regulation of liver fibrosis. The underlying epigenetic mechanism is not fully appreciated. In the present
Jun Lu, Junli Guo
exaly +3 more sources
BRG1 exacerbates myocardial fibrosis after myocardial infarction by interacting with ZEB1 [PDF]
Frontiers in PharmacologyBackgroundMyocardial fibrosis, characterized by excessive collagen deposition and fibroblast activation, is a pivotal pathological process driving heart failure after myocardial infarction (MI).
Yunfeng Cui +15 more
doaj +2 more sources
Antioxidant N-Acetylcysteine Attenuates the Reduction of Brg1 Protein Expression in the Myocardium of Type 1 Diabetic Rats [PDF]
Journal of Diabetes Research, 2013 Brahma-related gene 1 (Brg1) is a key gene in inducing the expression of important endogenous antioxidant enzymes, including heme oxygenase-1 (HO-1) which is central to cardioprotection, while cardiac HO-1 expression is reduced in diabetes. It is unknown
Jinjin Xu +9 more
doaj +4 more sources
The BRG1 chromatin remodeler protects against ovarian cysts, uterine tumors, and mammary tumors in a lineage-specific manner. [PDF]
PLoS ONE, 2012 The BRG1 catalytic subunit of SWI/SNF-related complexes is required for mammalian development as exemplified by the early embryonic lethality of Brg1 null homozygous mice.
Daniel W Serber +8 more
doaj +1 more source
iScience, 2023 Summary: We aimed to investigate the mechanisms of Brahma related gene 1 (BRG1) in promoting vascular calcification in chronic kidney disease (CKD). The expression of BRG1 was examined in high phosphorus stimulated rat aortic smooth muscle cells (RASMCs)
Yunlin Feng +10 more
doaj +1 more source
Journal of Translational Medicine, 2023 Background Progressive peritoneal fibrosis is a worldwide public health concern impacting patients undergoing peritoneal dialysis (PD), yet there is no effective treatment.
Shuting Li +12 more
doaj +1 more source