Results 31 to 40 of about 18,515 (257)

Unraveling How Candida albicans Forms Sexual Biofilms. [PDF]

, 2020
Biofilms, structured and densely packed communities of microbial cells attached to surfaces, are considered to be the natural growth state for a vast majority of microorganisms.
Hernday, Aaron D, Nobile, Clarissa J, Perry, Austin M   +2 more
core   +1 more source

BRG1 and NPM-ALK Are Co-Regulated in Anaplastic Large-Cell Lymphoma; BRG1 Is a Potential Therapeutic Target in ALCL [PDF]

Cancers, 2021
Anaplastic large-cell lymphoma (ALCL) is a T-cell malignancy driven in many cases by the product of a chromosomal translocation, nucleophosmin–anaplastic lymphoma kinase (NPM-ALK). NPM-ALK activates a plethora of pathways that drive the hallmarks of cancer, largely signalling pathways normally associated with cytokine and/or T-cell receptor-induced ...
Gavin D. Garland, Stephen P. Ducray, Leila Jahangiri, Perla Pucci, G. A. Amos Burke, Jack Monahan, Raymond Lai, Olaf Merkel, Ana-Iris Schiefer, Lukas Kenner, Andrew J. Bannister, Suzanne D. Turner   +11 more
openaire   +4 more sources

A long non-coding RNA protects the heart from pathological hypertrophy [PDF]

, 2014
The role of long noncoding RNA (lncRNA) in adult hearts is unknownalso unclear is how lncRNA modulates nucleosome remodeling. An estimated 70% of mouse genes undergo antisense transcription, including myosin heavy chain 7 (Myh7) that encodes molecular ...
Ashley, Euan, Bernstein, Daniel, Chang, Ching-Pin, Chen, Huei-sheng Vincent, Chen, Peng-Sheng, Chien, Huanchieh, Han, Pei, Jin, Kevin Kai, Li, Wei, Lin, Chieh-Yu, Lin, Chien-Jung, Lin, Chiou-Hong, Nuernberg, Sylvia T., Quertermous, Thomas, Shang, Ching, Xiong, Yiqin, Xu, Weihong, Yang, Jin, Zhou, Bin   +18 more
core   +5 more sources

Modulation of extracellular matrix/adhesion molecule expression by BRG1 is associated with increased melanoma invasiveness

Molecular Cancer, 2010
Background Metastatic melanoma is an aggressive malignancy that is resistant to therapy and has a poor prognosis. The progression of primary melanoma to metastatic disease is a multi-step process that requires dynamic regulation of gene expression ...
Chin Khew-Voon, Qi Huiling, Marathe Himangi G, Keenen Bridget, Saladi Srinivas, de la Serna Ivana L   +5 more
doaj   +1 more source

Determinants of a transcriptionally competent environment at the GM-CSF promoter [PDF]

, 2015
Granulocyte macrophage-colony stimulating factor (GM-CSF) is produced by T cells, but not B cells, in response to immune signals. GM-CSF gene activation in response to T-cell stimulation requires remodelling of chromatin associated with the gene ...
Brettingham-Moore, Kate H, Chen, Xinxin, Holloway, Adele F, Oakford, P, Shannon, M Frances, Sprod, O R   +5 more
core   +1 more source

BRG1 governs glucocorticoid receptor interactions with chromatin and pioneer factors across the genome

eLife, 2018
The Glucocorticoid Receptor (GR) alters transcriptional activity in response to hormones by interacting with chromatin at GR binding sites (GBSs) throughout the genome.
Jackson A Hoffman, Kevin W Trotter, James M Ward, Trevor K Archer   +3 more
doaj   +1 more source

Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin [PDF]

, 2014
Actively transcribed regions of the genome are vulnerable to genomic instability. Recently, it was discovered that transcription is repressed in response to neighboring DNA double-strand breaks (DSBs).
Alex D. Herbert, Amani Ismail, Andreas Kakarougkas, Anna L. Chambers, Brownlee, Campbell, Cao, Chambers, Chou, Enriqueta Riballo, Fradet-Turcotte, Francia, Ginjala, Goodarzi, Jessica A. Downs, Julia Künzel, Khavari, Lin, Markus Löbrich, Mathas, Matsuoka, Mattiroli, Mosesso, Noon, Oum, Papamichos-Chronakis, Penny A. Jeggo, Rulten, Schaaf, Shain, Shanbhag, Shema-Yaacoby, Shibata, Stiff, Varela, Vissers, Wei   +36 more
core   +1 more source

BRG1 Links TLR4 Trans-Activation to LPS-Induced SREBP1a Expression and Liver Injury

Frontiers in Cell and Developmental Biology, 2021
Multiple organ failure is one of the most severe consequences in patients with septic shock. Liver injury is frequently observed during this pathophysiological process. In the present study we investigated the contribution of Brahma related gene 1 (BRG1),
Wenhui Dong, Yuwen Zhu, Yangxi Zhang, Zhiwen Fan, Ziyu Zhang, Ziyu Zhang, Xiangshan Fan, Yong Xu, Yong Xu   +8 more
doaj   +1 more source

Trithorax group proteins: switching genes on and keeping them active [PDF]

, 2011
Cellular memory is provided by two counteracting groups of chromatin proteins termed Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate transcription and are perhaps best known because of the involvement of the TrxG protein ...
Cavalli, G., Iovino, N., Martinez, A., Schuettengruber, B.   +3 more
core   +1 more source

SWI/SNF regulates a transcriptional programme that induces senescence to prevent liver cancer [PDF]

, 2016
Oncogene-induced senescence (OIS) is a potent tumour suppressor mechanism. To identify senescence regulators relevant to cancer, we screened an shRNA library targeting genes deleted in hepatocellular carcinoma (HCC).
Banito, A, Carroll, T, Deswal, S, Garcia-Escudero, R, Ghamarlingam, G, Gil, J, Gonzalez Meljem, JM, Hohmeyer, A, Khan, S, Klotz, S, Martin, N, Martinez-Barbero, JP, Pedro, J, Raguz, S, Tordella, L, Zender, L, Zuber, J   +16 more
core   +2 more sources