Brg1 is required for Cdx2-mediated repression of Oct4 expression in mouse blastocysts.
PLoS ONE, 2010 During blastocyst formation the segregation of the inner cell mass (ICM) and trophectoderm is governed by the mutually antagonistic effects of the transcription factors Oct4 and Cdx2.
Kai Wang +5 more
doaj +1 more source
Frontiers in Oncology, 2023 SMARCA4 (BRG1)-deficient undifferentiated carcinoma is a rare and highly aggressive malignancy. It has been reported to occur in a multiple range of organs.
Xiangpeng Meng +6 more
doaj +1 more source
Epigenomes in Cardiovascular Disease. [PDF]
, 2018 If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and ...
McKinsey TA +4 more
core +1 more source
BRG1 HSA domain interactions with BCL7 proteins are critical for remodeling and gene expression
Life Science Alliance, 2023 Interactions between the BRG1 HSA domain and the B-cell CLL/lymphoma 7 proteins facilitate BRG1-mediated chromatin remodeling and induce changes in the gene expression of essential biological pathways.
Nicholas Dietrich +3 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Sterol response element binding protein (SREBP) is a master regulator of cellular lipogenesis. One key step in the regulation of SREBP activity is its sequential cleavage and trans-location by several different proteinases including SREBP cleavage ...
Ming Kong +6 more
doaj +1 more source
Hepatocellular Brg1 promotes CCl4-induced liver inflammation, ECM accumulation and fibrosis in mice.
PLoS ONE, 2023 IntroductionHepatic fibrosis is a progressive pathological process involving the exhaustion of hepatocellular regenerative capacity and ultimately leading to the development of cirrhosis and even hepatocellular carcinoma.
Baocai Wang +10 more
doaj +1 more source
Intratumoral heterogeneity analysis reveals hidden associations between protein expression losses and patient survival in clear cell renal cell carcinoma. [PDF]
, 2017 Intratumoral heterogeneity (ITH) is a prominent feature of kidney cancer. It is not known whether it has utility in finding associations between protein expression and clinical parameters. We used ITH that is detected by immunohistochemistry (IHC) to aid
Devarajan, Karthik +10 more
core +3 more sources
Brg1 Supports B Cell Proliferation and Germinal Center Formation Through Enhancer Activation
Frontiers in Immunology, 2021 Activation and differentiation of B cells depend on extensive rewiring of gene expression networks through changes in chromatin structure and accessibility. The chromatin remodeling complex BAF with its catalytic subunit Brg1 was previously identified as
Dominik Schmiedel +3 more
doaj +1 more source
The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16 [PDF]
, 2009 Background CDKN2A/p16INK4a is frequently altered in human cancers and it is the most important melanoma susceptibility gene identified to date. p16INK4a inhibits pRb phosphorylation and induces cell cycle arrest, which is considered its main tumour ...
Mann Graham J +10 more
core +2 more sources
Multifunctional adaptor protein Daxx interacts with chromatin-remodelling ATPase Brg1
Biochemistry and Biophysics Reports, 2016 Multifunctional adapter and chaperone protein Daxx participates in the regulation of a number of mainly transcription-related processes. Most notably in a complex with chromatin-remodelling ATPase ATRX, Daxx serves as a histone H3.3 chaperone at ...
Jan Svadlenka +4 more
doaj +1 more source