Results 21 to 30 of about 18,515 (257)
Transcriptional Repression by the BRG1-SWI/SNF Complex Affects the Pluripotency of Human Embryonic Stem Cells [PDF]
Stem Cell Reports, 2014 The SWI/SNF complex plays an important role in mouse embryonic stem cells (mESCs), but it remains to be determined whether this complex is required for the pluripotency of human ESCs (hESCs).
Xiaoli Zhang +13 more
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SMARCA4/BRG1-Deficient Sinonasal Carcinoma [PDF]
Archives of Pathology & Laboratory Medicine, 2021 Context.— Molecular analysis of poorly differentiated/undifferentiated sinonasal neoplasms has resulted in identification of a growing number of genetically defined tumors. SMARCA4-deficient sinonasal carcinoma is one such recently described entity that emerged from within sinonasal undifferentiated carcinoma ...
Aanchal, Kakkar +6 more
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The BRG1 transcriptional coregulator [PDF]
Nuclear Receptor Signaling, 2008 The packaging of genomic DNA into chromatin, often viewed as an impediment to the transcription process, plays a fundamental role in the regulation of gene expression. Chromatin remodeling proteins have been shown to alter local chromatin structure and facilitate recruitment of essential factors required for transcription. Brahma-related gene-1 (BRG1),
Trotter, Kevin W., Archer, Trevor K.
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LKB1 Associates with Brg1 and Is Necessary for Brg1-induced Growth Arrest [PDF]
Journal of Biological Chemistry, 2001 Inactivating mutations in the serine-threonine kinase LKB1 (STK11) are found in most patients with Peutz-Jeghers syndrome; however the function of LKB1 is unknown. We found that LKB1 binds to and regulates brahma-related gene 1 (Brg1), an essential component of chromatin remodeling complexes.
P A, Marignani, F, Kanai, C L, Carpenter
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Regulation of ATM and ATR by Smarcal1 and BRG1 [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2018 ABSTRACT The G2/M checkpoint is activated on DNA damage by the ATM and ATR kinases that are regulated by post-translational modifications. In this paper, the transcriptional co-regulation of ATM and ATR by SMARCAL1 and BRG1, both members of the ...
Sethy, Ramesh +7 more
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Oncogene-dependent function of BRG1 in hepatocarcinogenesis [PDF]
Cell Death & Disease, 2020 AbstractHepatocellular carcinoma (HCC) is the major type of primary liver cancer. Genomic studies have revealed that HCC is a heterogeneous disease with multiple subtypes. BRG1, encoded by the SMARCA4 gene, is a key component of SWI/SNF chromatin-remodeling complexes. Based on TCGA studies, somatic mutations of SMARCA4 occur in ~3% of human HCC samples.
Pan Wang +12 more
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Targetable Brg1‐CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking
EMBO Molecular Medicine, 2023 Alcoholic liver disease (ALD) accounts for a large fraction of patients with cirrhosis and hepatocellular carcinoma. In the present study we investigated the involvement of Brahma‐related gene 1 (Brg1) in ALD pathogenesis and implication in ALD ...
Nan Li +8 more
doaj +1 more source
BRG1 inhibits glycolysis by promoting SHP1-mediated dephosphorylation of PKM2 in non-small cell lung cancer. [PDF]
OncogenesisZhan W +7 more
europepmc +3 more sources
BRG1 is a prognostic marker and potential therapeutic target in human breast cancer. [PDF]
PLoS ONE, 2013 BRG1, a core component of the SWI/SNF chromatin-remodeling complex, has been implicated in cancer development; however, the biological significance of BRG1 in breast cancer remains unknown. We explored the role of BRG1 in human breast cancer pathogenesis.
Jin Bai +7 more
doaj +1 more source