Results 11 to 20 of about 18,515 (257)

The Role of BRG1 in Antioxidant and Redox Signaling [PDF]

Oxidative Medicine and Cellular Longevity, 2020
Redox homeostasis is regulated by critical molecules that modulate antioxidant and redox signaling (ARS) within the cell. Imbalances among these molecules can lead to oxidative stress and damage to cell functions, causing a variety of diseases. Brahma-related gene 1 (BRG1), also known as SMARCA4, is the central ATPase catalytic subunit of the switch ...
Shilong You, Ying Zhang, Jiaqi Xu, Hao Qian, Shaojun Wu, Boquan Wu, Saien Lu, Yingxian Sun, Naijin Zhang   +8 more
  +5 more sources

On the Interaction Between SMARCAL1 and BRG1

Frontiers in Cell and Developmental Biology, 2022
SMARCAL1 and BRG1, both classified as ATP-dependent chromatin remodeling proteins, play a role in double-strand break DNA damage response pathways. Mutations in SMARCAL1 cause Schimke Immuno-osseous Dysplasia (SIOD) while mutations in BRG1 are associated
Deepa Bisht, Ketki Patne, Radhakrishnan Rakesh, Rohini Muthuswami   +3 more
doaj   +3 more sources

ARID1 and BRG1 Expression in Endometrial Cancer [PDF]

In Vivo
Endometrial cancer (EC) is the predominant malignancy among gynecologic cancers and ranks fourth among all types of cancer. Recently, researchers have focused on the development of new prognostic biomarkers. Subunits of the SWI/SNF protein complex, like the ARID1 and BRG1, have been associated with the development of endometrial cancer.
Kontomanolis, Emmanuel N., Symeonidis, Panagiotis, Nikolettos, Konstantinos, Perros, Paraskevas, Rody, Achim, Tsikouras, Panagiotis, Nikolettos, Nikolaos, Giatromanolaki, Alexandra   +7 more
openaire   +4 more sources

EVI1 Promotes Cell Proliferation by Interacting with BRG1 and Blocking the Repression of BRG1 on E2F1 Activity [PDF]

Journal of Biological Chemistry, 2003
EVI1 is a complex protein required for embryogenesis and inappropriately expressed in many types of human myeloid leukemia. Earlier we showed that the forced expression of EVI1 in murine hematopoietic precursor cells leads to their abnormal differentiation and increased proliferation. In this report, we show that EVI1 physically interacts with BRG1 and
Yiqing, Chi, Vitalyi, Senyuk, Soumen, Chakraborty, Giuseppina, Nucifora   +3 more
openaire   +4 more sources

BRG1 promotes hepatocarcinogenesis by regulating proliferation and invasiveness. [PDF]

PLoS ONE, 2017
The chromatin remodeler complex SWI/SNF plays an important role in physiological and pathological processes. Brahma related gene 1(BRG1), a catalytic subunit of the SWI/SNF complex, is known to be mutated in hepatocellular carcinoma (HCC).
Benedikt Kaufmann, Baocai Wang, Suyang Zhong, Melanie Laschinger, Pranali Patil, Miao Lu, Volker Assfalg, Zhangjun Cheng, Helmut Friess, Norbert Hüser, Guido von Figura, Daniel Hartmann   +11 more
doaj   +5 more sources

The chromatin remodeling protein BRG1 regulates HSC-myofibroblast differentiation and liver fibrosis [PDF]

Cell Death and Disease, 2023
Excessive fibrogenic response in the liver disrupts normal hepatic anatomy and function heralding such end-stage liver diseases as hepatocellular carcinoma and cirrhosis.
Yuwen Zhu, Aoqi Kang, Yameng Kuai, Yan Guo, Xiulian Miao, Li Zhu, Ming Kong, Nan Li   +7 more
doaj   +2 more sources

TTF1-positive SMARCA4/BRG1 deficient lung adenocarcinoma [PDF]

Journal of Pathology and Translational Medicine, 2022
SMARCA4/BRG1-deficient lung adenocarcinoma (SD-LUAD) is being recognized as a distinct subtype based on subtle differences in its clinical, morphological, and immunophenotypic attributes compared to other non–small cell lung carcinomas. We present here a
Anurag Mehta, Himanshi Diwan, Divya Bansal, Manoj Gupta   +3 more
doaj   +4 more sources

E2F6 associates with BRG1 in transcriptional regulation. [PDF]

PLoS ONE, 2012
The E2F6 protein functions as an Rb-independent repressor of gene transcription. We have previously provided evidence suggesting a role for E2F6 in repression of E2F-responsive genes at S phase.
Janet Y Leung, Joseph R Nevins
doaj   +4 more sources

BRG1 is a biomarker of hypertrophic cardiomyopathy in human heart specimens

Scientific Reports, 2022
Hypertrophic cardiomyopathy (HCM) is a genetic disease of the sarcomere that causes otherwise unexplained cardiac hypertrophy and is associated with sudden death.
Jacob C. Scherba, Marc K. Halushka, Nicholas D. Andersen, Joseph J. Maleszewski, Andrew P. Landstrom, Nenad Bursac, Carolyn Glass   +6 more
doaj   +3 more sources

An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm [PDF]

, 2018
Thoracic aortic aneurysm (TAA) has been associated with mutations affecting members of the TGF-β signaling pathway, or components and regulators of the vascular smooth muscle cell (VSMC) actomyosin cytoskeleton.
A Dobin, AM Bertoli-Avella, B Zhang, BL Loeys, C Boileau, CAD Consortium, CL Zhang, CT Hang, D Wang, DB Sparrow, DC Guo, DC Guo, DP Judge, E Crosas-Molist, EM Gallo, EM Isselbacher, ES Regalado, G Arun, G Jondeau, H Pannu, HC Dietz, IM Laar van de, International Stroke Genetics, C., J Zhou, JJ Tomasek, JP Habashi, K Chang, L Wang, L Yang, L Zhu, M Filarsky, M Furlan-Magaril, M Liao, M Zhang, ME Lindsay, ME Lindsay, ME Lindsay, MH Schulz, MS Leisegang, N Grewal, N Kato, N Sakalihasan, N Visa, P Han, Q Cao, Q Xi, R Holtwick, RE Pyeritz, S Azghandi, S Goodall, S Inamoto, SB Timraz, SV Costes, T Foroud, TA McKinsey, TK Chatterjee, TK Chatterjee, TM Holm, UK Muppirala, V Tripathi, Y Qi, Y Sun, Y Yamashiro, Y Yuan   +63 more
core   +5 more sources