Results 61 to 70 of about 18,515 (257)
Under the Microscope: A Case Report of Thoracic SMARCA4-Deficient Undifferentiated Tumor with Review of the Literature [PDF]
Türk Patoloji DergisiObjective: SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) is a highly malignant neoplasm with an undifferentiated or rhabdoid phenotype, posing a diagnostic challenge.
Manasi MUNDADA +4 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Fulminant hepatitis (FH) is a major cause of acute liver failure. Concanavalin A (ConA) belongs to the lectin family and is frequently used as an inducer of FH in animal models. ConA induced FH is characterized by massive accumulation of T lymphocytes in
Wenxuan Hong +11 more
doaj +1 more source
High affinity binding of H3K14ac through collaboration of bromodomains 2, 4 and 5 is critical for the molecular and tumor suppressor functions of PBRM1. [PDF]
, 2018 Polybromo-1 (PBRM1) is an important tumor suppressor in kidney cancer. It contains six tandem bromodomains (BDs), which are specialized structures that recognize acetyl-lysine residues.
Alicea-Velázquez, Nilda L. +10 more
core +2 more sources
BRG1 and BRM loss selectively impacts RB and P53, respectively: BRG1 and BRM have differential functions in vivo [PDF]
Oncoscience, 2016 The SWI/SNF complex is an important regulator of gene expression that functions by interacting with a diverse array of cellular proteins. The catalytic subunits of SWI/SNF, BRG1 and BRM, are frequently lost alone or concomitantly in a range of different cancer types. This loss abrogates SWI/SNF complex function as well as the functions of proteins that
Marquez-Vilendrer, Stefanie B. +4 more
openaire +2 more sources
BRG1 Is Dispensable for Sertoli Cell Development and Functions in Mice [PDF]
International Journal of Molecular Sciences, 2020 Sertoli cells are somatic supporting cells in spermatogenic niche and play critical roles in germ cell development, but it is yet to be understood how epigenetic modifiers regulate Sertoli cell development and contribution to spermatogenesis. BRG1 (Brahma related gene 1) is a catalytic subunit of the mammalian SWI/SNF chromatin remodeling complex and ...
Shuai Wang +3 more
openaire +2 more sources
Endothelial Brg1 fine-tunes Notch signaling during zebrafish heart regeneration
npj Regenerative Medicine, 2023 Myocardial Brg1 is essential for heart regeneration in zebrafish, but it remains unknown whether and how endothelial Brg1 plays a role in heart regeneration.
Chenglu Xiao +9 more
doaj +1 more source
Angewandte Chemie, Volume 138, Issue 15, 6 April 2026.Targeted covalent inhibitors (TCI) containing cyclic imine warheads react with tyrosine and tryptophan residues via the Mannich reaction. These cyclic imine warheads show comparable reaction kinetics to cysteine‐reactive electrophiles commonly used in TCIs.
Sijie Wang +6 more
wiley +2 more sources
SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis
Nature Communications, 2018 Upstream pathways regulating Brg1 stability and their role in carcinogenesis are unknown. Here they show Brg1 to be phosphorylated by CK1δ to promote its ubiquitination by SCFFBW7 (FBW7), Brg1 stabilization to promote gastric cancer metastasis, and ...
Li-Yu Huang +12 more
doaj +1 more source
PLoS Genetics, 2014 Tumourigenesis within the intestine is potently driven by deregulation of the Wnt pathway, a process epigenetically regulated by the chromatin remodelling factor Brg1.
Aliaksei Z Holik +7 more
doaj +1 more source
A role for chromatin remodellers in replication of damaged DNA [PDF]
, 2011 In eukaryotic cells, replication past damaged sites in DNA is regulated by the ubiquitination of proliferating cell nuclear antigen (PCNA). Little is known about how this process is affected by chromatin structure.
Chambers, Anna L +3 more
core +2 more sources