eLife, 2020 Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and aggressive form of ovarian cancer. SCCOHT tumors have inactivating mutations in SMARCA4 (BRG1), one of the two mutually exclusive ATPases of the SWI/SNF chromatin remodeling ...
Krystal Ann Orlando +22 more
doaj +1 more source
BRG1 interacts with SOX10 to establish the melanocyte lineage and to promote differentiation [PDF]
, 2017 Mutations in SOX10 cause neurocristopathies which display varying degrees of hypopigmentation. Using a sensitized mutagenesis screen, we identified Smarca4 as a modifier gene that exacerbates the phenotypic severity of Sox10 haplo-insufficient mice ...
Aras, S +12 more
core +1 more source
Trans-activation of eotaxin-1 by Brg1 contributes to liver regeneration
Cell Death and Disease, 2022 Infiltration of eosinophils is associated with and contributes to liver regeneration. Chemotaxis of eosinophils is orchestrated by the eotaxin family of chemoattractants. We report here that expression of eotaxin-1 (referred to as eotaxin hereafter), but
Zhiwen Fan +14 more
doaj +1 more source
Critical parameters for efficient sonication and improved chromatin immunoprecipitation of high molecular weight proteins [PDF]
, 2016 Solubilization of cross-linked cells followed by chromatin shearing is essential for successful chromatin immunoprecipitation (ChIP). However, this task, typically accomplished by ultrasound treatment, may often become a pitfall of the process, due to ...
Adams, Peter D. +2 more
core +2 more sources
Mechanism of BRG1 silencing in primary cancers
Oncotarget, 2016 BRG1 (SMARCA4) is a documented tumor suppressor and a key subunit of the SWI/SNF chromatin remodeling complex that is silenced in many cancer types. Studies have shown that BRG1 is mutated in cancer-derived cell lines, which led to the assertion that BRG1 is also mutated in primary human tumors.
Marquez, Stefanie B. +3 more
openaire +3 more sources
Epigenetic reprogramming of muscle progenitors: inspiration for clinical therapies [PDF]
, 2015 In the context of regenerative medicine, based on the potential of stem cells to restore diseased tissues, epigenetics is becoming a pivotal area of interest.
Consalvi, Silvia +2 more
core +4 more sources
myomiR-dependent switching of BAF60 variant incorporation into Brg1 chromatin remodeling complexes during embryo myogenesis [PDF]
, 2014 Myogenesis involves the stable commitment of progenitor cells followed by the execution of myogenic differentiation, processes that are coordinated by myogenic regulatory factors, microRNAs and BAF chromatin remodeling complexes.
Bajard +52 more
core +1 more source
, 2018 Background: The chromatin remodelers of the SWI/SNF family are critical transcriptional regulators. Recognition of lysine acetylation through a bromodomain (BRD) component is key to SWI/SNF function; in most eukaryotes, this function is attributed to ...
Burtch, Alyson +9 more
core +1 more source
Pathological Ace2-to-Ace enzyme switch in the stressed heart is transcriptionally controlled by the endothelial Brg1–FoxM1 complex [PDF]
, 2016 Genes encoding angiotensin-converting enzymes (Ace and Ace2) are essential for heart function regulation. Cardiac stress enhances Ace, but suppresses Ace2, expression in the heart, leading to a net production of angiotensin II that promotes cardiac ...
Chang, Ching-Pin +9 more
core +1 more source
Identification of H3K4me1-associated proteins at mammalian enhancers. [PDF]
, 2017 Enhancers act to regulate cell-type-specific gene expression by facilitating the transcription of target genes. In mammalian cells, active or primed enhancers are commonly marked by monomethylation of histone H3 at lysine 4 (H3K4me1) in a cell-type ...
Albuquerque, Claudio P +13 more
core +2 more sources