Results 141 to 150 of about 9,962 (180)

Oxidation of baicalein by tyrosinase and by o-quinones

International Journal of Biological Macromolecules, 2023
Baicalein (5,6,7-trihydroxyflavone) has been previously described as an inhibitor of tyrosinase (Guo et al. Int. J. Biol. Macromol. 118 (2018) 57-68). However, long before this article was published this flavonoid had been shown to be a substrate of this enzyme and a catecholic cofactor partially abolishing the lag-phase during oxidation of l-tyrosine.
Beata Gąsowska-Bajger, Hubert Wojtasek
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Total synthesis of baicalein

Journal of Asian Natural Products Research, 2010
In this paper, a simple and novel synthesis of baicalein is described. This transformation features the novel synthesis of helilandin B and a different way to demethylate. The overall yield of 59% is acceptable.
Duo-Zhi, Chen, Jian, Yang, Bo, Yang, Yuan-Shuang, Wu, Ting, Wu   +4 more
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A strategy to improve the oral availability of baicalein: The baicalein-theophylline cocrystal

Fitoterapia, 2018
Baicalein (BE) is a flavonoid compound derived from the roots of Scutellaria baicalensis. It has widely been used as anti-oxidant, anti-virus, anti-bacteria, anti-inflammatory and anti-allergic therapies. Due to its poor water solubility (16.82 μg/ml), the therapeutic effectiveness and oral bioavailability of Baicalein are highly limited.
Wen Li, Jiaxin Pi, Ying Zhang, Xutong Ma, Bing Zhang, Shuya Wang, Dongli Qi, Nan Li, Pan Guo, Zhidong Liu   +9 more
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Baicalein and 12/15-Lipoxygenase in the Ischemic Brain [PDF]

Stroke, 2006
Background and Purpose— The natural product baicalein is a specific inhibitor of 12/15-lipoxygenase, but it also has antioxidant properties. The current study was designed to test if the neuroprotective properties of baicalein are related to its lipoxygenase inhibition.
Hahn Young Kim, Eng Lo, Klaus Van Leyen   +2 more
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Comparative studies on the interactions of baicalein and Al(III)–baicalein complex with human serum albumin

Luminescence, 2015
AbstractA new potential drug aluminum(III)–baicalein complex (ALBC) was synthesized and characterized. The binding mechanisms of baicalein (BC) and ALBC to human serum albumin (HSA) under simulative physiological conditions were investigated, in order to understand the pharmacokinetics of BC and ALBC.
Jing, Wang, Qing, Wang, Di, Wu, Jin, Yan, You, Wu, Hui, Li   +5 more
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Free Radical Scavenging Action of Baicalein

Archives of Biochemistry and Biophysics, 1993
TJ-960 is a Japanese Kampo (traditional herbal) medicine used for the treatment of epilepsy. It's a crude drug, an extract of nine herbs, and consists of many known and unknown components. Among the known components of TJ-960, we found that 5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one (baicalein) might be the most potent scavenger for radicals.
H, Hamada, M, Hiramatsu, R, Edamatsu, A, Mori   +3 more
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Metabolic Interaction between Ammonia and Baicalein

Chemical Research in Toxicology, 2020
Ammonia is treated as a primary waste product of cellular metabolism in vivo and can contribute to the alteration of neurotransmission, oxidative stress, and cerebral edema and astrocyte swelling when its concentration in the brain is high. The objective of this study was to determine whether bioactive polyphenol baicalein had the capacity to trap ...
Shuwei Zhang, Ronghui Wang, Yantao Zhao, Fakir Shahidullah Tareq, Shengmin Sang   +4 more
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A 1:1 cocrystal of baicalein with nicotinamide

Acta Crystallographica Section C Crystal Structure Communications, 2012
Cocrystallization of baicalein with nicotinamide yields a 1:1 cocrystal [systematic name: pyridine-3-carboxamide–5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one (1/1)], C6H6N2O·C15H10O5. The asymmetric unit contains one baicalein and one nicotinamide molecule, both in neutral forms.
Michał, Sowa, Katarzyna, Ślepokura, Ewa, Matczak-Jon   +2 more
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Baicalein attenuates oxidant stress in cardiomyocytes

American Journal of Physiology-Heart and Circulatory Physiology, 2002
Flavonoids within Scutellaria baicalensis may be potent antioxidants on the basis of our studies of S. baicalensis extract. To further this work, we studied the antioxidative effects of baicalein, a flavonoid component of S. baicalensis, in a chick cardiomyocyte model of reactive oxygen species (ROS) generation during hypoxia, simulated ischemia ...
Zuo-Hui, Shao, Terry L, Vanden Hoek, Yimin, Qin, Lance B, Becker, Paul T, Schumacker, Chang-Qing, Li, Lucy, Dey, Eugene, Barth, Howard, Halpern, Gerald M, Rosen, Chun-Su, Yuan   +10 more
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Baicalein: A metabolite with promising antineoplastic activity

Life Sciences, 2020
Cancer, being a multifactorial disease has diverse presentation in different subgroups which is mainly attributed to heterogenous presentation of tumor cells. This cancer cell heterogeneity is the major reason for variable response to standard chemotherapeutic regimes owing to which high relapse rate and multi-drug resistance has increasingly been ...
Hardeep Singh, Tuli, Vaishali, Aggarwal, Jagjit, Kaur, Diwakar, Aggarwal, Gaurav, Parashar, Nidarshana Chaturvedi, Parashar, Muobarak, Tuorkey, Ginpreet, Kaur, Raj, Savla, Katrin, Sak, Manoj, Kumar   +10 more
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