Results 211 to 220 of about 20,980 (270)

Baicalin inhibits hepatocellular carcinoma cell growth and metastasis by suppressing ROCK1 signaling

Phytotherapy Research, 2023
Hepatocellular carcinoma (HCC) is a common malignancy affecting many people worldwide. Baicalin is a flavonoid extracted from the dried root of Scutellaria baicalensis Georgi. It can effectively inhibit the occurrence and development of HCC. Nonetheless,
Jialing Sun, Xuemei Yang, Haitao Sun, Shao-hui Huang, H. An, Wei Xu, Weicong Chen, Wenting Zhao, Chunyu He, Xiaodan Zhong, Tong Li, Yang Liu, Bin Wen, Qingfeng Du, Songqi He   +14 more
semanticscholar   +1 more source

Mechanisms of Baicalin Alleviates Intestinal Inflammation: Role of M1 Macrophage Polarization and Lactobacillus amylovorus

Advancement of science
Baicalin has been widely used for its anti‐inflammatory pharmacological properties, yet its effects on bacterial intestinal inflammation and the mechanisms remain unclear.
Shunfen Zhang, R. Zhong, Miao Zhou, Kai Li, Huiyuan Lv, Huixin Wang, Ye Xu, Dadan Liu, Qiugang Ma, Liang Chen, Hongfu Zhang   +10 more
semanticscholar   +1 more source

Baicalin Reduces Immune Cell Infiltration by Inhibiting Inflammation and Protecting Tight Junctions in Ischemic Stroke Injury.

The American Journal of Chinese Medicine, 2023
Ischemic stroke is a serious health hazard that lacks effective treatment strategies. This study aims to investigate baicalin's effect on tight junctions and immune cell infiltration after ischemic stroke injury. Rat brain microvascular endothelial cells
Zhiyuan Hao, Zheyu Zhang, Yuhang Zhao, Dongsheng Wang   +3 more
semanticscholar   +1 more source

Baicalin: an active natural product with potential medicinal values

Journal of Asian natural products research
Baicalin, a flavonoid derived from the dicotyledonous plant Scutellaria baicalensis Georgi (SBG), is applied to treat various disorders due to its various pharmacological effects such as anti-inflammatory, antiviral, antibacterial, liver-protecting ...
Yong-Qiang Wen, Ya-Zhou Wang, Chen-Xu Zhao, Bao-Yu Zhao, Jianguo Wang   +4 more
semanticscholar   +1 more source

Study of baicalin scavenging hydroxyethyl peroxyl radicals by radiolysis of aerated ethanol-baicalin system

Radiation Physics and Chemistry, 1996
Abstract The reaction of baicalin (β- d -glucopyranosiduronic acid, 5,6-dihydroxy-oxo-2-phenyl-4H-1-benzopyran-7-yl) scavenging hydroxyethyl peroxyl radicals (RO 2 . ) was studied with the aid of radiolysis of aerated ethanol. Two main stable products were separated by reverse HPLC and their possible molecular structures were derived from their UV ...
null Cai Zhongli, null He Yongke, null Wu Jilan   +2 more
openaire   +1 more source

Application of QbD based approach in development and validation of RP-HPLC method for simultaneous estimation of Methotrexate and Baicalin in Dual-Drug Loaded Liposomes.

Biomedical chromotography, 2023
The present study delineates the development of a novel rugged and sensitive stability indicating risk-based HPLC method for the concurrent estimation of methotrexate (MTX) and baicalin (BCL) in dual drug-loaded-nanopharmaceuticals based on an analytical
S. Adin, I. Gupta, M. Aqil, M. Mujeeb
semanticscholar   +1 more source

Baicalin attenuates angiotensin II-induced endothelial dysfunction

Biochemical and Biophysical Research Communications, 2015
Angiotensin II (Ang II) has been shown to activate multiple downstream pathways resulting in endothelial dysfunction and oxidative stress. Baicalin, a natural flavone, exerts anti-oxidant and anti-apoptotic effects in cardiovascular diseases. In the present study, we hypothesized that baicalin has beneficial effects in Ang II-induced endothelial cells ...
Xiling Wei, Xingyu Zhu, Nan Hu, Xiuqin Zhang, Tianjiao Sun, Jiyang Xu, Xiaohong Bian   +6 more
openaire   +2 more sources

Baicalin Nanocomplexes with an In Situ-Forming Biomimetic Gel Implant for Repair of Calvarial Bone Defects via Localized Sclerostin Inhibition.

ACS Applied Materials and Interfaces, 2023
In situ-forming hydrogels are highly effective in covering complex and irregular tissue defects. Herein, a biomimetic gel implant (CS-GEL) consisting of methacrylated chondroitin sulfate and gelatin is obtained via visible light irradiation, which ...
Chenrui Li, Junru Wang, Yining Niu, Haonan Zhang, Hongling Ouyang, Guangwei Zhang, Yao Fu   +6 more
semanticscholar   +1 more source

Baicalin induces ferroptosis in oral squamous cell carcinoma by suppressing the activity of FTH1

Journal of Gene Medicine
This study investigated the role of the ferroptosis‐related gene FTH1 in oral squamous cell carcinoma (OSCC) and evaluated the therapeutic potential of baicalin in OSCC cell treatment.
Zhihao Wen, Yuxiao Zhang, Bo Gao, Xin Chen   +3 more
semanticscholar   +1 more source

Baicalin promotes antibacterial defenses by modulating mitochondrial function

Biochemical and Biophysical Research Communications, 2022
Natural flavonoids, such as baicalin, have been extensively studied for their role in bacterial infection. However, the underlying mechanisms remain poorly understood. We demonstrated that baicalin coordinates mitochondrial function and dynamics to promote antibacterial response.
Dongjiu, Zhao, Binhao, Du, Jihao, Xu, Qinzi, Xie, Zhe, Lu, Yanhua, Kang   +5 more
openaire   +2 more sources