Results 21 to 30 of about 10,947 (224)

Baicalin relieves hypoxia-aroused H9c2 cell apoptosis by activating Nrf2/HO-1-mediated HIF1α/BNIP3 pathway

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Background Myocardial ischemia is the main reason for ischemic heart disease. Baicalin is a plant-derived flavonoid with cardio-protective activity.
Hailiang Yu, Bin Chen, Qi Ren
doaj   +1 more source

Chemoprotective effect of baicalin against cyclophosphamide induced ovarian toxicity in mice via inhibition of TGF-β

Heliyon, 2023
Ovarian toxicity is most common gynecologically related malignancy, arising for most cases owing to the advanced stage of diagnosis. The aim of the current study was to explore the anticancer potential of baicalin against cyclophosphamide (CP) induced ...
Xuefeng Li, Juan Yue, Yogesh Kumar, Yannan Ma   +3 more
doaj   +1 more source

Baicalin attenuates lipopolysaccharide-induced pro-inflammatory cytokine expression in murine macrophage cell line RAW264.7 through miR-124-STAT3 axis

European Journal of Inflammation, 2018
Baicalin, a flavonoid isolated from Scutellaria baicalensis Georgi, has shown a wide range of anti-inflammatory, antioxidative, antiviral, and antitumor properties.
Bin Tang, Xixi Wang, Yuqing Zhu, Xuhui Li, Shukun Yao   +4 more
doaj   +1 more source

Baicalin Induces Apoptosis in SW620 Human Colorectal Carcinoma Cells in Vitro and Suppresses Tumor Growth in Vivo

Molecules, 2012
In the United States, colorectal cancer (CRC) is the second most frequent malignancy and the fourth most common cause of cancer death. Baicalin, a flavone derivative isolated and purified from the dry root of Scutellaria, was assessed for its antitumor ...
Yi-Shiuan Tzeng, Ying-Chieh Tsai, Tsu-Hsiang Kuo, Wen-Cheng Chen   +3 more
doaj   +1 more source

Baicalin regulates macrophages polarization and alleviates myocardial ischaemia/reperfusion injury via inhibiting JAK/STAT pathway

Pharmaceutical Biology, 2020
Context Baicalin is an active compound which demonstrates cardioprotection effects against myocardial ischaemia/reperfusion injury (MI/RI). Objective To investigate how baicalin protects against myocardial injury and to explore its potential mechanism ...
Ming Xu, XiaoYong Li, Laichun Song
doaj   +1 more source

Protective effects of baicalin magnesium on non-alcoholic steatohepatitis rats are based on inhibiting NLRP3/Caspase-1/IL-1β signaling pathway

BMC Complementary Medicine and Therapies, 2023
Baicalin magnesium is a water-soluble compound isolated from the aqueous solution by Scutellaria baicalensis Georgi. Preliminary experiments have demonstrated that baicalin magnesium can exert protective effects against acute liver injury in rats induced
Xiulu Guan, Shiyuan Shen, Jinxia Liu, Hongru Song, Jinhua Chang, Xiaoxia Mao, Jingyu Song, Lin Zhang, Cuizhe Liu   +8 more
doaj   +1 more source

Dynamic Covalent Hydrogel of Natural Product Baicalin With Antibacterial Activities

, 2022
Baicalin has been demonstrated to have multiple pharmacological activities but low solubility. Various baicalin hydrogels have been used to improve its solubility and break its limitation in clinical applications.
Wang, Zhen-Zhen, He, Hongjuan, Shi, Yanmei, Wang, Guoqiang, Cao, Lihua, Miao, Mingsan, Li, Xiu-Min, Jia, Yuan   +7 more
core   +1 more source

Baicalin ameliorates atherosclerosis by inhibiting NLRP3 inflammasome in apolipoprotein E-deficient mice

Diabetes & Vascular Disease Research, 2020
Background: NLR family pyrin domain containing 3 (NLRP3) inflammasome has been implicated in the development of atherosclerosis and several studies have suggested that inhibiting NLRP3 inflammasome could be a potential therapeutic approach to treat ...
Jingfei Zhao, Zhengtang Wang, Zhilu Yuan, Shuzhen Lv, Qingbo Su   +4 more
doaj   +1 more source

Baicalin acts as an adjuvant to potentiate the activity of azithromycin against Staphylococcus saprophyticus biofilm: an in vitro, in vivo, and molecular study

Veterinary Research, 2022
Staphylococcus saprophyticus is frequently involved in various difficult-to-treat infections due to the formation of biofilms. To identify useful antibiofilm strategies, this study explored the efficacy and mechanism of baicalin in enhancing the ability ...
Jinli Wang, Siya Li, Jinwu Meng, Jinyue Zhu, Tianxin Qiu, Wenjia Wang, Jinxue Ding, Zhenguang Liu, Kun Li, Mujahid lqbal, Deyun Wang, Yi Wu, Jiaguo Liu   +12 more
doaj   +1 more source

Modulation of P1 and EGF Expression by Baicalin [PDF]

International Journal of Molecular Sciences, 2012
Mycoplasma pneumoniae (M. pneumoniae) is increasingly recognized as a major cause of acute respiratory tract infections. Today, macrolides are used in the primary treatment of M. pneumoniae infection. However, with the increasing prevalence of strains resistant to macrolides, as well as reports of toxicity and adverse side effects, it is necessary to ...
Yanli Meng, Jinhai Huo, Weihong Lu, Xin Wang, Junwei Zhang, Weiming Wang   +5 more
openaire   +2 more sources