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The Antiviral Effect of Baicalin on Enterovirus 71 In Vitro

Viruses, 2015
Baicalin is a flavonoid compound extracted from Scutellaria roots that has been reported to possess antibacterial, anti-inflammatory, and antiviral activities. However, the antiviral effect of baicalin on enterovirus 71 (EV71) is still unknown.
Fei Xing, Weifeng Shi, Shi Weifeng
exaly   +4 more sources

Dietary baicalin supplementation enhances growth performance in fattening Hu sheep via dual modulation of immunity and gastrointestinal microbiome-metabolic crosstalk [PDF]

Journal of Animal Science and Biotechnology
Background Baicalin is a bioactive flavonoid from Scutellaria baicalensis Georgi with antioxidant, anti‑inflammatory and antibacterial properties. However, its bitter taste and susceptibility to ruminal degradation limit its practical use in mammals ...
Di Ding, Yu Zhang, Haoliang Tian, Binghan Dong, Xin Wu, Shaohua Liu, Tengyun Gao, Liyang Zhang, Tong Fu   +8 more
doaj   +2 more sources

Baicalin induces apoptosis and autophagy in human osteosarcoma cells by increasing ROS to inhibit PI3K/Akt/mTOR, ERK1/2 and β-catenin signaling pathways

Journal of Bone Oncology, 2022
Baicalin, a flavonoid derivative, exerts antitumor activity in a variety of neoplasms. However, whether baicalin exerts antitumor effects on osteosarcoma cells remains to be elucidated. In this study, treatment with baicalin reduced the proliferation and
Tingrui Wu
exaly   +3 more sources

Baicalin inhibits infectious bronchitis virus replication via MAVS-dependent interferon-β upregulation and mitochondrial function preservation [PDF]

Scientific Reports
The inhibitory effect of baicalin on infectious bronchitis virus (IBV) replication is closely related to expression of the mitochondrial antiviral signaling protein (MAVS) in chicken embryonic kidney (CEK) cells.
Jiongjie He, Huilin Guo, Ling Wang, Shengyi Wang   +3 more
doaj   +2 more sources

Protective effect of baicalin against cognitive memory dysfunction after splenectomy in aged rats and its underlying mechanism [PDF]

Journal of Integrative Neuroscience, 2020
Postoperative cognitive dysfunction is a common neurological complication, characterized by impaired learning and memory, that occurs after anesthesia and surgery, especially in elderly patients. The traditional Chinese medicine baicalin is known to have
Jian-Nan Zhang, Hong-Mei Zhou, Chen-Hao Jiang, Jiao Liu, Liang-Yu Cai   +4 more
doaj   +1 more source

Exploring the protective mechanism of baicalin in treatment of atherosclerosis using endothelial cells deregulation model and network pharmacology

BMC Complementary Medicine and Therapies, 2022
Background Baicalin is a generally available flavonoid with potent biological activity. The present study aimed to assess the underlying mechanism of baicalin in treatment of atherosclerosis (AS) with the help of network pharmacology, molecular docking ...
Mingshuang Li, Conglin Ren
doaj   +1 more source

Baicalin protects the cardiomyocytes from ER stress-induced apoptosis: inhibition of CHOP through induction of endothelial nitric oxide synthase. [PDF]

PLoS ONE, 2014
Baicalin, the main active ingredient of the Scutellaria root, exerts anti-oxidant and anti-apoptotic effects in cardiovascular diseases. However, the therapeutic mechanism of baicalin remains unknown. Cultured neonatal rat cardiomyocytes were pre-treated
Mingzhi Shen, Lin Wang, Guodong Yang, Lei Gao, Bo Wang, Xiaowang Guo, Chao Zeng, Yong Xu, Liangliang Shen, Ke Cheng, Yuesheng Xia, Xiumin Li, Haichang Wang, Li Fan, Xiaoming Wang   +14 more
doaj   +1 more source

Baicalin Relieves LPS-Induced Lung Inflammation via the NF-κB and MAPK Pathways

Molecules, 2023
Baicalin is an active ingredient extracted from the Chinese medicine Scutellaria and has many beneficial effects. Pulmonary interstitial and alveolar edema are common symptoms of an acute lung injury (ALI).
Bingyu Shen, Haoqing Zhang, Zhengjin Zhu, Zixi Ling, Fangyuan Zeng, Yazhou Wang, Jianguo Wang   +6 more
doaj   +1 more source

Facilitating Granule Cell Survival and Maturation in Dentate Gyrus With Baicalin for Antidepressant Therapeutics

Frontiers in Pharmacology, 2020
Baicalin isolated from Scutellaria baicalensis possesses antidepressant abilities through its relation to hippocampal neurogenesis. Current research has found that baicalin can promote the proliferation of hippocampal granule cells, however, the detailed
Fan Zhao, Weiwei Tao, Zhiyuan Shang, Weihua Zhang, Jie Ruan, Chenyiyu Zhang, Liping Zhou, Hunter Aiello, Hezheng Lai, Hezheng Lai, Rong Qu   +10 more
doaj   +1 more source

Baicalin protects against renal interstitial fibrosis in mice by inhibiting the TGF-β/Smad signalling pathway

Pharmaceutical Biology, 2022
Context Baicalin, a flavonoid extracted from radix scutellariae, possesses various pharmacological effects, including protective effects on renal interstitial fibrosis (RIF), but its possible role and mechanisms have not been fully elucidated.Objective ...
Hui Wang, Qingtao Jiang, Lizhu Zhang
doaj   +1 more source