Results 41 to 50 of about 928 (146)

Microglia in neuropathology caused by protozoan parasites

Biological Reviews, Volume 95, Issue 2, Page 333-349, April 2020., 2020
ABSTRACT Involvement of the central nervous system (CNS) is the most severe consequence of some parasitic infections. Protozoal infections comprise a group of diseases that together affect billions of people worldwide and, according to the World Health Organization, are responsible for more than 500000 deaths annually. They include African and American
Katherine Figarella, Hartwig Wolburg, Olga Garaschuk, Michael Duszenko   +3 more
wiley   +1 more source

Balamuthia mandrillarisexhibits metalloprotease activities [PDF]

FEMS Immunology & Medical Microbiology, 2006
Balamuthia mandrillaris is a recently identified protozoan pathogen that can cause fatal granulomatous encephalitis. However, the pathogenesis and pathophysiology of B. mandrillaris encephalitis remain unclear. Because proteases may play a role in the central nervous system (CNS) pathology, we used spectrophotometric, cytopathic and zymographic assays ...
Abdul, Matin, Monique, Stins, Kwang Sik, Kim, Naveed Ahmed, Khan   +3 more
openaire   +2 more sources

Discovery of repurposing drug candidates for the treatment of diseases caused by pathogenic free-living amoebae.

PLoS Neglected Tropical Diseases, 2020
Diseases caused by pathogenic free-living amoebae include primary amoebic meningoencephalitis (Naegleria fowleri), granulomatous amoebic encephalitis (Acanthamoeba spp.), Acanthamoeba keratitis, and Balamuthia amoebic encephalitis (Balamuthia ...
Christopher A Rice, Beatrice L Colon, Emily Chen, Mitchell V Hull, Dennis E Kyle   +4 more
doaj   +1 more source

A Case of Balamuthia mandrillaris Meningoencephalitis [PDF]

Archives of Neurology, 2000
Balamuthia mandrillaris is a newly described pathogen that causes granulomatous amebic encephalitis, an extremely rare clinical entity that usually occurs in immunosuppressed individuals. We report a case of pathologically proven Balamuthia encephalitis with unusual laboratory and radiologic findings.
J D, Katz, A H, Ropper, L, Adelman, M, Worthington, P, Wade   +4 more
openaire   +2 more sources

Identification of plicamycin, TG02, panobinostat, lestaurtinib, and GDC-0084 as promising compounds for the treatment of central nervous system infections caused by the free-living amebae Naegleria, Acanthamoeba and Balamuthia

International Journal for Parasitology: Drugs and Drug Resistance, 2019
The free-living amebae Naegleria, Acanthamoeba, and Balamuthia cause rare but life-threatening infections. All three parasites can cause meningoencephalitis.
Monica M. Kangussu-Marcolino, Gretchen M. Ehrenkaufer, Emily Chen, Anjan Debnath, Upinder Singh   +4 more
doaj   +1 more source

ISEV2023 Abstract Book

, 2023
Journal of Extracellular Vesicles, Volume 12, Issue S1, May 2023.
wiley   +1 more source

Molecular analysis unmasking a Balamuthia mandrillaris: Skin lesion and granulomatous amebic encephalitis by Acanthamoeba sp close to genotype T4 with fatal outcome

Clinical Infection in Practice
Background: Acanthamoeba sp, Balamuthia mandrillaris, are a free-living soil amoeba, has emerged as a causative agent of chronic GAE. Methods: The nasal biopsy was sent to our Laboratory of Pathogenic Protozoa and Endosymbionts (LPEP).
Alfonso Martín Cabello-Vílchez, M. Isabel Ruiz-Ruiz   +1 more
doaj   +1 more source

Isolation and identification of free-living amoeba from the hot springs and beaches of the Caspian Sea

Parasite Epidemiology and Control, 2020
Free-living amoeba (FLA) such as Acanthamoeba, Naegleria, Balamuthia, and Vermamoeba have been identified from both natural and human-made environments such as Hot springs and spa. Naegleria fowleri causes Primary Amoebic Meningoencephalitis (PAM), while
Alireza Latifi, Mahboobeh Salami, Elham Kazemirad, Mohammad Soleimani   +3 more
doaj   +1 more source

Pathogenic free-living amoebic encephalitis from 48 cases in China: A systematic review

Frontiers in Neurology, 2023
BackgroundFree-living amoebae (FLA) including Naegleria fowleri, Acanthamoeba spp., and Balamuthia mandrillaris can become pathogenic and cause severe cerebral infections, named primary amoebic meningoencephalitis (PAM), granulomatous amoebic ...
Xiang-Ting Chen, Qian Zhang, Si-Yuan Wen, Fei-Fei Chen, Chang-Qing Zhou   +4 more
doaj   +1 more source

Balamuthia mandrillaris: Morphology, biology, and virulence

Tropical Parasitology, 2015
Balamuthia mandrillaris is a protist pathogen that can cause encephalitis with a fatality rate of >95%. This is due to our incomplete understanding of the pathogenesis and pathophysiology of B. mandrillaris encephalitis. B. mandrillaris has two stages in its life cycle, an active trophozoite stage during which it divides mitotically.
Siddiqui, Ruqaiyyah, Khan, Naveed Ahmed
openaire   +3 more sources