Results 91 to 100 of about 7,382,338 (337)

A Simplified Balanced ‘Balanced Scorecard’

open access: yesEuropean Accounting and Management Review, 2019
This paper proposes a performance measurement system (PMS) based on the Balanced Scorecard (BSC) that requires only 25 common key performance indictors (KPIs), which are characterized by their easiness to collect, in turn making the PMS an affordable instrument for all types of organizations, regardless of their resource availability.
Ivan Malbašić, Frederic Marimon
openaire   +2 more sources

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

open access: yesFEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke   +2 more
wiley   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

Off-balance sheet exposures and banking crises in OECD countries [PDF]

open access: yes, 2012
Against the background of the acknowledged importance of off-balance-sheet exposures in the sub prime crisis, we seek to investigate whether this was a new phenomenon or common to earlier crises.
Barrell, R   +3 more
core  

Stringy Probe Particle and Force Balance [PDF]

open access: yes, 1999
We directly derive the classical equation of motion, which governs the centre of mass of a test string, from the string action. In a certain case, the equation is basically same as one derived by Papapetrou, Dixon and Wald for a test extended body.
A. Papapetrou   +28 more
core   +2 more sources

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

Work and Family [PDF]

open access: yes, 1999
This survey offers in-depth analysis of workers' ability to balance work and family, the policies made available by employers to help their employees achieve this balance, and workers' attitudes about the policies designed to address the need to balance ...

core  

Confronting the United Nations’ Pro-growth Agenda

open access: yesThe Journal of Population and Sustainability
In this article, we enjoin the United Nations (UN) to forge a path out of our plight of multiple environmental and social crises. With other analysts, we identify ‘overshoot’ – the state in which humanity has substantially outpaced Earth’s capacity to ...
Nandita Bajaj   +2 more
doaj   +1 more source

Characterization of HA-tagged α9 and α10 nAChRs in the mouse cochlea

open access: yesScientific Reports, 2020
Neurons of the medial olivary complex inhibit cochlear hair cells through the activation of α9α10-containing nicotinic acetylcholine receptors (nAChRs).
Pankhuri Vyas   +6 more
doaj   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

open access: yesFEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil   +5 more
wiley   +1 more source

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