Results 91 to 100 of about 9,265,447 (383)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Spatial Orientation Impairment in Patients With Bilateral Vestibulopathy and Persistent Postural–Perceptual Dizziness

Brain and Behavior
Background Two chronic forms of dizziness—bilateral vestibulopathy (BVP) with a loss of vestibular input, and functional dizziness with normal vestibular function—present with the key symptom of postural and gait imbalance.
Vivien Oertle, Sandra Becker‐Bense, Thomas Brandt, Marianne Dieterich, Johannes Gerb   +4 more
doaj   +1 more source

Experimental Study on the Seismic Performance of Pre-Inserted Prefabricated Shear Walls

Buildings
The pre-inserted method for precast shear walls involves casting concealed beams at floor slabs between upper and lower structures, with precast concrete supports spaced at intervals.
Quanbiao Xu, Shenghang Yang, Benyue Li, Mingwei Xu, Mingshan Zhang   +4 more
doaj   +1 more source

Noisy Galvanic Stimulation Improves Roll-Tilt Vestibular Perception in Healthy Subjects

Frontiers in Neurology, 2018
It has recently been demonstrated that noisy galvanic vestibular stimulation (nGVS) delivered as imperceptible white noise can improve balance control via the induction of stochastic resonance.
Aram Keywan, Max Wuehr, Cauchy Pradhan, Klaus Jahn, Klaus Jahn   +4 more
doaj   +1 more source

A Measurement of Newton's Gravitational Constant [PDF]

, 2006
A precision measurement of the gravitational constant $G$ has been made using a beam balance. Special attention has been given to determining the calibration, the effect of a possible nonlinearity of the balance and the zero-point variation of the ...
A. H. Slocum, C. C. Speake, E. Holzschuh, F. Nolting, J. Schurr, L. B. Rall, R. E. Pixley, R. J. Barlow, S. P. Timoshenko, St. Schlamminger, U. Straumann, W. Glaser, W. Kündig   +12 more
core   +2 more sources

Temperature sensitivity of anaerobic methane oxidation versus methanogenesis in paddy soil: Implications for the CH₄ balance under global warming [PDF]

, 2021
Lichao Fan, Michaela A. Dippold, Volker Thiel, Tida Ge, Jinshui Wu, Yakov Kuzyakov, Maxim Dorodnikov   +6 more
openalex   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Applications of Structural Balance in Signed Social Networks [PDF]

, 2014
We present measures, models and link prediction algorithms based on the structural balance in signed social networks. Certain social networks contain, in addition to the usual 'friend' links, 'enemy' links.
Kunegis, Jérôme
core