Results 101 to 110 of about 1,542,707 (296)
Book-keeping in Mesopotamia in the Third and Second Millennium BC
Copernican Journal of Finance & Accounting, 2013 The recent, twentieth-century research on the history of the development of book-keeping indicates that it originated with the development of the Sumerian civilization in the third millennium BC. The necessity to control the property of the temple and of
Sławomir Sojak
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Grant Kajii and Polak (2000, Journal of Economic Theory) have identified weak decomposability as the key axiom to characterise the betweenness class for acts without the assumption of probabilistic sophistication, leaving, however, a small gap between necessary and sufficient conditions.
Roorda, Berend, Joosten, Reinoud A.M.G.
openaire +3 more sources
A Reserve-Balancing Pool for Services by Dairy Cooperatives [PDF]
The rationale for compensating dairy cooperatives for the costs incurred in balancing milk supply for the fluid market is examined. A reserve-balancing pool is proposed to facilitate deducting supply-balancing service credit from a marketwide producer ...
Ling, K. Charles
core +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
, 2011 Principal balances are defined as a sequence of orthonormal balances which maximize successively the explained variance in a data set. Apparently, computing principal balances requires an exhaustive search along all possible sets of orthogonal balances. This is unaffordable for even a small number of parts.
Pawlowsky Glahn, Vera +2 more
openaire +4 more sources