Results 111 to 120 of about 1,542,707 (296)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Experimental Analysis of Balance-Induced Vibrations in Vehicle Shafts
Düzce Üniversitesi Bilim ve Teknoloji DergisiExtensive research has been conducted in recent years to mitigate damages caused by undesired vibrations in motor vehicles used for transportation. Vibrations occurring in highly active moving components of vehicles not only lead to discomfort in driving
Menderes Kalkat +2 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Dissociated development of growth and skeletal robustness, and motor skills of preschool children
Human Biology and Public HealthBackground Lack of physical activity is associated with various health risks. Yet, instead of indulging their natural urge to move, the majority of today’s preschool children tends to spend a substantial portion of the day in sedentary pursuit ...
Chantal Laura-Mari Delor +2 more
doaj
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
FA-CRAN: A Firefly Algorithm for Dynamic BBU-RRH Mapping in Cloud/Centralized Radio Access Networks
IEEE AccessC-RAN (Cloud Radio Access Network) is an architecture designed to the new generation of mobile networks. It has handled many problems arising from the 4-generation network, and made several improvements, such as centralized processing and energy ...
Mariane de Paula da Silva Goncalves Imbiriba +7 more
doaj +1 more source
Analyzing the Network Response Time and Load Balancing [PDF]
This paper describes the network response time which represent a significant indicator for network performance and how load balancing can improve the network performance.response time, load balancing, throughput, network ...
Madalina MLAK
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