Results 121 to 130 of about 470,317 (318)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
, 2017 The paper presents a general formal framework representing the role of balancing of values in interpretation of statutory rules. The model developed here is an extension of the model of teleological interpretation, where a given interpretive outcome is justified if it satisfies a given goal (or a set of goals).
Michal Araszkiewicz, Tomasz Zurek
openaire +2 more sources
Balancing : balancing of shafts : presentation transcript
, 2010 This is a presentation about the balancing of shafts and supports the Edexcel HN unit – Design for Manufacture (NQF L4). The requirement to provide balance for rotating systems is a vital component in ensuring long, reliable service.
Leicester College Technology and Engineering Centre
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Experimental Analysis of Balance-Induced Vibrations in Vehicle Shafts
Düzce Üniversitesi Bilim ve Teknoloji DergisiExtensive research has been conducted in recent years to mitigate damages caused by undesired vibrations in motor vehicles used for transportation. Vibrations occurring in highly active moving components of vehicles not only lead to discomfort in driving
Menderes Kalkat +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Dissociated development of growth and skeletal robustness, and motor skills of preschool children
Human Biology and Public HealthBackground Lack of physical activity is associated with various health risks. Yet, instead of indulging their natural urge to move, the majority of today’s preschool children tends to spend a substantial portion of the day in sedentary pursuit ...
Chantal Laura-Mari Delor +2 more
doaj