Results 111 to 120 of about 1,513,785 (298)
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
, 2011 Principal balances are defined as a sequence of orthonormal balances which maximize successively the explained variance in a data set. Apparently, computing principal balances requires an exhaustive search along all possible sets of orthogonal balances. This is unaffordable for even a small number of parts.
Pawlowsky Glahn, Vera +2 more
openaire +4 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
An applicational process for dynamic balancing of turbomachinery shafting [PDF]
The NASA Lewis Research Center has developed and implemented a time-efficient methodology for dynamically balancing turbomachinery shafting. This methodology minimizes costly facility downtime by using a balancing arbor (mandrel) that simulates the ...
Verhoff, Vincent G.
core +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Experimental Analysis of Balance-Induced Vibrations in Vehicle Shafts
Düzce Üniversitesi Bilim ve Teknoloji DergisiExtensive research has been conducted in recent years to mitigate damages caused by undesired vibrations in motor vehicles used for transportation. Vibrations occurring in highly active moving components of vehicles not only lead to discomfort in driving
Menderes Kalkat +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Dissociated development of growth and skeletal robustness, and motor skills of preschool children
Human Biology and Public HealthBackground Lack of physical activity is associated with various health risks. Yet, instead of indulging their natural urge to move, the majority of today’s preschool children tends to spend a substantial portion of the day in sedentary pursuit ...
Chantal Laura-Mari Delor +2 more
doaj
Identification of dynamic characteristics of flexible rotors as dynamic inverse problem [PDF]
The problem of dynamic and balancing of flexible rotors were considered, which were set and solved as the problem of the identification of flexible rotor systems, which is the same as the inverse problem of the oscillation theory dealing with the task of
Roisman, W. P., Vajingortin, L. D.
core +1 more source