Results 91 to 100 of about 282,395 (263)

Rapid Non-Destructive Detection of Rice Seed Vigor via Terahertz Spectroscopy

Agriculture
Rice seed vigor significantly impacts yield, making the selection of high-vigor seeds crucial for agricultural production. Traditional methods for assessing seed vigor are time-consuming and destructive.
Jun Hu, Sijie Xu, Zhikai Huang, Wennan Liu, Jiahao Zheng, Yuxi Liao   +5 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Weed Detection: Innovative Hyperspectral Image Analysis for Classification and Band Selection of Site-Specific and Selective Weeding Robot

Agronomy
Weeding in melon and watermelon fields requires selective and pinpoint operation because the crop plants are sensitive to herbicides and tend to grow on the ground in all directions.
Asi Lazar, Inbar Meir, Ran Nisim Lati, Avital Bechar   +3 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Self-Supervised Deep Multi-Level Representation Learning Fusion-Based Maximum Entropy Subspace Clustering for Hyperspectral Band Selection

Remote Sensing
As one of the most important techniques for hyperspectral image dimensionality reduction, band selection has received considerable attention, whereas self-representation subspace clustering-based band selection algorithms have received quite a lot of ...
Yulei Wang, Haipeng Ma, Yuchao Yang, Enyu Zhao, Meiping Song, Chunyan Yu   +5 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Band Selection via Band Density Prominence Clustering for Hyperspectral Image Classification

Remote Sensing
Band clustering has been widely used for hyperspectral band selection (BS). However, selecting an appropriate band to represent a band cluster is a key issue.
Chein-I Chang, Yi-Mei Kuo, Kenneth Yeonkong Ma   +2 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Multi-band frequency-selective surfaces with independent band tuning

, 2023
To design a frequency selective surface (FSS) enabling narrow-band pseudo-elliptic transmission of incident TE-polarized wave in a single-band or multi-band operating regime.To design a FSS enabling mixed-type frequency response, namely closely-spaced transmission of incident TE-polarized and its reflection simultaneously.To design a FSS providing ...
Mospan, Liudmyla, Zelenchuk, Dmitry
openaire   +2 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source