Results 101 to 110 of about 289,355 (305)

Rapid Non-Destructive Detection of Rice Seed Vigor via Terahertz Spectroscopy

Agriculture
Rice seed vigor significantly impacts yield, making the selection of high-vigor seeds crucial for agricultural production. Traditional methods for assessing seed vigor are time-consuming and destructive.
Jun Hu, Sijie Xu, Zhikai Huang, Wennan Liu, Jiahao Zheng, Yuxi Liao   +5 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Weed Detection: Innovative Hyperspectral Image Analysis for Classification and Band Selection of Site-Specific and Selective Weeding Robot

Agronomy
Weeding in melon and watermelon fields requires selective and pinpoint operation because the crop plants are sensitive to herbicides and tend to grow on the ground in all directions.
Asi Lazar, Inbar Meir, Ran Nisim Lati, Avital Bechar   +3 more
doaj   +1 more source

Global attentional selection of visual features is not associated with selective modulation of posterior alpha‐band activity [PDF]

, 2023
Christopher Gundlach, Norman Forschack, Matthias M. Müller   +2 more
openalex   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Self-Supervised Deep Multi-Level Representation Learning Fusion-Based Maximum Entropy Subspace Clustering for Hyperspectral Band Selection

Remote Sensing
As one of the most important techniques for hyperspectral image dimensionality reduction, band selection has received considerable attention, whereas self-representation subspace clustering-based band selection algorithms have received quite a lot of ...
Yulei Wang, Haipeng Ma, Yuchao Yang, Enyu Zhao, Meiping Song, Chunyan Yu   +5 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Transfer Function Based Band Selection in Frequency Domain Time Series Regression

, 2020
Skye Griffith, Wesley S. Burr, Glen Takahara   +2 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

HYPERSPECTRAL IMAGE BAND SELECTION BASED ON SUBSPACE CLUSTERING

, 2021
Zhijun Zheng, Yanbin Peng
openalex   +2 more sources