Results 61 to 70 of about 289,355 (305)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Incorporating band selection in the spatial selection of spectral endmembers
International Journal of Applied Earth Observations and Geoinformation, 2020 The impact of band selection on endmember selection is seldom explored in the analysis of hyperspectral imagery. This study incorporates the N-dimensional Spectral Solid Angle (NSSA) band selection tool into the Spectral-Spatial Endmember Extraction ...
Yaqian Long, Benoit Rivard, Derek Rogge
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Distributed Resource Allocation for D2D-Assisted Small Cell Networks With Heterogeneous Spectrum
IEEE Access, 2019 Device-to-device (D2D) communication with increased spectral efficiency and reduced communication delay has undoubtedly become a general trend in future wireless networks.
Yuanfei Liu +3 more
doaj +1 more source
Optimal Bands Combination Selection for Extracting Garlic Planting Area with Multi-Temporal Sentinel-2 Imagery [PDF]
, 2021 Shuang Wu +5 more
openalex +1 more source
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande +11 more
wiley +1 more source
Frontiers in Earth ScienceHyperspectral data from the Airborne Visible and Infra-Red Imaging Spectrometer – Next-Generation (AVIRIS-NG) offers transformative potential for Earth science research, enabling detailed analysis of land surface processes, resource monitoring, and ...
Veerendra Satya Sylesh Peddinti +3 more
doaj +1 more source